Diagnostic value of 5 miRNAs combined detection for breast cancer.

Background: Breast cancer (BC) is the prevailing malignant tumor, with its prevalence and death rate steadily rising over time. BC often does not show obvious symptoms in its early stages and is difficult to distinguish from benign breast disease. We aimed to find a distinct group of miRNAs utilizing serum as a non-invasive biomarker for early BC diagnosis.

Impact of the gut microbiota-Th17 cell axis on inflammatory depression.

Depression is a serious cognitive disorder that results in significant and pervasive deficits in social behavior. These deficits can be traced back to the intricate interplay between social, psychological, and biological factors. Inflammatory depression, a treatment-resistant or non-responsive subtype of depression, may be related to the interaction between the gut microbiota and interleukin-17-producing CD4 T cells (Th17 cells).

Resistance mechanisms and prospects of trastuzumab.

Breast cancer that overexpresses Human Epidermal Growth Factor Receptor 2 (HER2+) due to gene amplification or overexpression constitutes 15-20% of all breast cancer cases. Trastuzumab, the first FDA-approved monoclonal antibody targeting HER2, serves as the standard first-line treatment for HER2-positive advanced breast cancer, as recommended by multiple clinical guidelines.Currently, accumulated clinical evidence reveals a considerable degree of variability in the response of HER2+ breast cancer to trastuzumab treatment.

Corrigendum: Long non-coding RNA SNHG1 regulates the Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways EZH2 to affect the proliferation, apoptosis, and autophagy of prostate cancer cell.

[This corrects the article DOI: 10.3389/fonc.2020.

The relative effects of climatic drivers and phenotypic integration on phenotypic plasticity of a globally invasive plant.

Introduction: Understanding the constraints of phenotypic plasticity can provide insights into the factors that limit or influence the capacity of an organism to respond to changing environments. However, the relative effects of external and internal factors on phenotypic plasticity remain largely unexplored. Phenotypic integration, the pattern of correlations among traits, is recognized as an important internal constraint to plasticity.

Correlation between remnant cholesterol and premature coronary artery disease and the severity of coronary artery lesions in men: a retrospective study.

Objective: To investigate the correlation between remnant cholesterol (RC) and premature coronary artery disease (PCAD) and the severity of coronary artery lesions in men.

Methods: A total of 630 male subjects who underwent coronary angiography were included in the study. The general data, laboratory tests, and coronary angiography data of each group were statistically analyzed, and RC levels were calculated.

Antiproliferative effects of resorcylic acid lactones from the Beibu Gulf coral-derived fungus GXIMD 02512 on prostate cancer cells.

Four novel resorcylic acid lactones (RALs), curvulomycins A-D (1-4), and six known congeners were isolated from the Beibu Gulf coral-derived fungus GXIMD 02512. Their structures including absolute configurations were established by extensive spectroscopic analyses along with experimental and calculated ECD spectra. Structurally, compound 3 harbors a unique γ-pyrone moiety rarely found in the natural RAL family.

Stanniocalcin-1 in tumor immunity: acts via macrophages.

Tumor immune escape has become a research hotspot in the field of cancer immunotherapy. Tumor-associated macrophages (TAMs) are the key component of tumor microenvironment, which play a pivotal role in tumor immune escape by regulating the immunity checkpoints, inhibiting the activity of T lymphocytes and natural killer (NK) cells, and modulating proportion of different T cells. Stanniocalcin-1(STC1)is ubiquitously expressed in human body, which is proven to involve with tumor progression and clinical prognosis.

Development of a pan-genotypic monoclonal antibody-based competitive ELISA for the detection of antibodies against Bovine viral diarrhea virus.

Introduction: Bovine viral diarrhea virus (BVDV), a positive-sense single-stranded RNA virus, causes significant economic losses in the cattle industry. Current diagnostic methods for BVDV exhibit variable sensitivity and specificity, underscoring the need for more rapid and accurate detection approaches. Here, we developed a novel competitive ELISA (cELISA) to detect antibodies against the BVDV E2 protein.

Characterization of a phage 4FS1 and its depolymerase.

The significant economic losses caused by in donkey husbandry have increased interest in exploring the potential of phages and their enzymes as control strategies. In this study, a phage, designated 4FS1, was isolated from sewage at a donkey farm. Transmission electron microscopy (TEM) revealed a typical icosahedral head and a long, non-contractile tail.

Serum neurotransmitter analysis of motor and non-motor symptoms in Parkinson's patients.

Clinical symptoms of Parkinson's disease (PD) are classified into motor and non-motor symptoms. Mental disorders, especially depression, are one of the major non-motor manifestations of PD. However, the underlying mechanisms remain poorly understood.

Clinical Use of Home OCT Data to Manage Neovascular Age-Related Macular Degeneration.

To investigate how home optical coherence tomography (OCT) influences the clinical decision-making of retina specialists for the management of neovascular age-related macular degeneration (nAMD). In this retrospective imaging review, 15 retina specialists each evaluated 10 home OCT data segments from 29 eyes being treated for nAMD. Based on OCT data, indications were identified for when eyes should be treated, which antivascular endothelial growth factor should be used, and the specific retinal fluid and time thresholds for notification.

Multi-task learning with multi-gate mixture of transformer-based experts for predictive process monitoring in manufacturing.

Manufacturing industries involve both business processes and complex manufacturing processes. Predictive process monitoring techniques are effective for managing process executions by making multi-perspective real-time predictions, preventing issues such as delivery delays. Conventional predictive process monitoring for business processes focuses on predicting the next activity, next event time, and remaining time using single-task learning, which is costly and complex.

Efficacy and safety of QingReJieDu therapy in preventing acute radiation esophagitis: A systematic review and meta-analysis.

Background: Acute radiation esophagitis (ARE) is a frequently observed complication of radiotherapy for malignant tumors. QingReJieDu (QRJD) therapy is commonly used for the prevention and treatment of ARE. There is a lack of evidence regarding the effectiveness and safety of traditional Chinese medicine in preventing ARE.

A feasibility study of DNA ploidy analysis, HPV, and TCT for screening of cervical cancer: A retrospective study.

The present study aimed to evaluate the application of DNA ploidy analysis, human papillomavirus (HPV-DNA) test, and thin-prep cytologic test (TCT) for mass screening of cervical cancer (CC). A total of 13,830 patients who underwent both TCT and HPV-DNA tests from June 2021 to June 2022 were selected as study participants (10,107 patients from Shandong Provincial Hospital, 2447 patients from First People's Hospital of Tancheng County, and 1276 patients from Liaocheng People's Hospital). We also conducted a DNA ploidy analysis and compared the results.

Comparative analysis of cancer statistics in China and the United States in 2024.

Background: Cancer patterns in China are becoming similar to those in the United States (US). Comparing the recent cancer profiles, trends, and determinants in China and the US can provide useful reference data.

Methods: This study used open-source data.

A Compact Piezo-Drive Rotatable Scanning Tunneling Microscope in a 12 T Cryogen-Free Magnet.

Atomically resolved scanning tunneling microscope (STM) capable of in situ rotation in a narrow magnet bore has become a long-awaited but challenging technique in the field of strong correlation studies since it can introduce the orientation of the strong magnetic field as a control parameter. This article presents the design and functionality of a piezoelectrically driven rotatable STM (RSTM), operating within a 12 T cryogen-free magnet and achieving a base temperature below 1.8 K, along with spectroscopic capabilities.

Diagnosis of Acute Versus Chronic Thoracolumbar Vertebral Compression Fractures Using CT Radiomics Based on Machine Learning: a Preliminary Study.

The purpose of this study is to evaluate the performance of radiomic models in acute thoracolumbar vertebral compression fractures (VCFs) and their impact on radiologists. In this monocentre retrospective study, eligible for inclusion were adults who underwent emergent thoracic/lumbar CT between May 2022 and November 2023 in our hospital diagnosed with thoracolumbar VCFs. The lesions were randomly divided at a ratio of 7:3 into a training set and test set.

Polyethylene microplastics distinctly affect soil microbial community and carbon and nitrogen cycling during plant litter decomposition.

Plant litter is an important input source of carbon and nitrogen in soil. While microplastics (MPs) and plant litter are ubiquitously present in soil, their combined impact on soil biogeochemical processes remains poorly understood. To address this gap, we examined the soil changes resulting from the coexistence of plant litter (Alfalfa) and polyethylene microplastics (PE).

The role of social determinants in alcohol consumption and cardiovascular health: The pathways study.

Background And Aims: The "J"-shaped relationship between alcohol consumption and cardiovascular health is recognized as potentially influenced by residual confounders, and this study aimed to clarify the role that social determinants play in the relationship.

Methods And Results: Using NHANES data from 2005 to 2018, this study analyzed 30,648 participants to assess how eight social determinants (employment, income, food security, education, healthcare access, insurance, housing stability, and marital status) influence the relationship between alcohol consumption and cardiovascular disease (CVD). Moderate drinking reduces CVD risk (HR: 0.

First Experience with the NPseal®: A Novel Mechanically Powered Negative Pressure Dressing Applied to Colorectal Surgery Wounds.

Background: The use of prophylactic closed-incisional negative pressure wound therapy after colorectal procedures has been shown to reduce postoperative wound complications and surgical site infection. We present our experience with a novel, closed-incision, mechanically powered negative pressure (MP-NPD) dressing after colorectal procedures.

Methods: This was a prospective, single-center, single-arm observational study assessing patient reported and wound healing outcomes of colorectal surgical incisions dressed with a MP-NPD.