Variation in Magnetic Memory Testing Signals and Their Relationship with Stress Concentration Factors During Fatigue Tests Based on Back-Propagation Neural Networks.

To investigate the relationship between metal magnetic memory testing (MMMT) signals and stress concentration factors (SCFs), four-level sinusoidal constant-amplitude load tension-tension fatigue tests were carried out on 45CrNiMoVA steel specimens with different SCFs. The normal component of MMMT signals, (), was collected during the fatigue tests, and three characteristics were extracted and analyzed during the tests, including the peak-to-peak value of abnormal peaks (Δ()), the slope coefficient of the fitting line of () (), and the slope coefficient of the fitting line of () between abnormal peaks (), and a back-propagation (BP) neural network was developed to differentiate the SCF of the specimens. The results showed that both fatigue load and fatigue cycle number influenced MMMT signals, and the characteristics remained stable as the fatigue cycle number increased for the same fatigue load but increased significantly as fatigue load increased.

Preparation and Effect of CO Response Gel for Plugging Low-Permeability Reservoirs.

In order to solve the problem of gas channeling during CO flooding in low-permeability reservoirs, a novel CO responsive gel channeling system was prepared by using carrageenan, branched polyethylene imide and ethylenediamine under laboratory conditions. Based on the Box-Behnken response surface design method, the optimal synthesis concentration of the system was 0.5 wt% carrageenan, 2.

Numerical Modeling of Foam Carrying Sand Transport in Multifactor Horizontal Wells.

The solution of wellbore multiphase flow models has an important position in oil-gas field development. However, the solution of multiphase flow models often involves a series of complicated situations such as interphase mass and energy transfer, surface problems, and so on. Foam carrying sand particles in the wellbore is a solid, liquid, and gas three-phase cylinder flow problem.

Clinical and molecular heterogeneity associated with tumor sidedness in colorectal liver metastasis: a multicenter propensity cohort study.

Background: Colorectal liver metastasis (CRLM) exhibits highly heterogeneity, with clinically and molecularly defined subgroups that differ in their prognosis. The aim of this study is to explore whether left-sided tumors is clinically and gnomically distinct from right-sided tumors in CRLM.

Methods: This retrospective study included 1,307 patients who underwent primary tumor and metastases resection at three academic centers in China from January 1, 2012, to December 31, 2020.

Effects of IFN-γ on the immunological microenvironment and TAM polarity in stage IA non-small cell lung cancer and its mechanisms.

Objective: To investigate the effect of interferon-γ (IFN-γ) on the immune microenvironment and the polarity of tumor-associated macrophages (TAMs) in stage IA non-small cell lung cancer (NSCLC) and its mechanisms.

Methods: Human non-small cell lung cancer A549 cells were treated with a series of IFN-γ concentrations (0, 50, 100, 150, 200, 250, and 300 ng/mL). Tumor tissues from patients with stage IA NSCLC were cultured using the air-liquid interface culture technique to establish a tumor microenvironment (TME) organ model.

Rapid Fabrication of Flexible Cu@Ag Flake/SAE Composites with Exceptional EMIS and Joule Heating Performance.

High electromagnetic interference shielding (EMIS) effectiveness and good thermal management properties are both required to meet the rapid development of integrated electronic components. However, it remains challenging to obtain environmentally friendly and flexible films with high EMIS and thermal management performance in an efficient and scalable way. In this paper, an environmentally friendly strategy is proposed to synthesize multifunctional waterborne Cu@Ag flake conductive films using water as the solvent and silicone-acrylic emulsion (SAE) as a matrix.

Artifacts in two-dimensional shear wave elastography of liver.

Background: Artifacts are common when using two-dimensional shear wave elastography (2-D SWE) to measure liver stiffness (LS), but they are poorly recognized.

Aim: To investigate the presence and influence of artifacts in 2-D SWE of liver.

Methods: We included 158 patients with chronic liver disease, who underwent 2-D SWE examination by a novice and an expert.

Electroacupuncture at Baliao point alleviates post-operative pain and anal distension after procedure for prolapse and hemorrhoids (stapled hemorrhoidopexy): a prospective randomized clinical trial.

Purpose: The purpose of this study was to explore the effect of electroacupuncture (EA) at Baliao point on short-term complications, such as anal pain and swelling, after procedure for prolapse and hemorrhoids (PPH) in patients with mixed hemorrhoids.

Methods: A total of 124 eligible patients undergoing PPH surgery were included in this study and randomly divided into a control group (n = 67) and an EA group (n = 57), with patients in the control group receiving only PPH surgery and patients in the EA group receiving PPH surgery and EA at Baliao point.

Results: The visual analogue scale (VAS) scores of EA group at 8, 24, 48, and 72 h after operation were significantly lower than those of control group.

Application of the intestine diversion tube with a double-balloon without ileostomy in low rectal cancer.

Background: Ileostomy is often used in low rectal cancer to protect the anastomosis and reduce the incidence of anastomotic leakage. However, the closure of the stoma causes physical and psychological damage to patients. An intestine diversion tube with a double-balloon was designed to remove the need for ileostomy and a secondary surgery, and we sought to verify its effectiveness and safety.

Clinical study on risk factors related to postoperative recurrence or metastasis of rectal cancer: a retrospective cohort study.

Background: Rectal cancer is usually treated by surgery, but recurrence or metastasis seriously affect the quality of life and survival of patients. Identifying the risk factors for postoperative recurrence or metastasis of rectal cancer has important guiding value for the treatment of rectal cancer. However, the research on risk factors of postoperative recurrence or metastasis of rectal cancer has not been unified.

Association of Simultaneous vs Delayed Resection of Liver Metastasis With Complications and Survival Among Adults With Colorectal Cancer.

Importance: Simultaneous or delayed resection of synchronous liver metastasis (SLM) with primary colorectal cancer (CRC) remains a controversial topic.

Objective: To investigate the outcomes of simultaneous vs delayed resection in patients with resectable SLM.

Design, Setting, And Participants: This comparative effectiveness research study included 1569 patients with resectable SLM who underwent curative-intent liver resection at 3 independent centers in China between January 1, 2000, to December 31, 2019.

Long non-coding RNA SNHG16 decreased SMAD4 to induce gemcitabine resistance in pancreatic cancer via EZH2-mediated epigenetic modification.

Gemcitabine resistance (GR) in pancreatic cancer (PC) results in poor patient outcomes. SMAD family member (Smad4) dysregulation is a significant role of GR in PC, and EZH2 is involved in Smad4 expression in tumor progression. Interestingly, lncRNA small nucleolar RNA host gene 16 (SNHG16) might interact with EZH2, indicating a potential pathway to overcome gemcitabine-resistant PC progression.

Copper-thiosemicarbazone complexes conjugated-cellulose fibers: Biodegradable materials with antibacterial capacity.

Personal protective equipment (PPE) is vital in battling bacteria crisis, but conventional PPE materials lack antimicrobial activities and environmental friendliness. Our work focused on developing biodegradable and antibacterial fibers as promising bioprotective materials. Here, we grafted highly effective antibacterial copper-thiosemicarbazone complexes (CT1-4) on cellulose fibers via covalent linkages.

Stress Evaluation of Welded Joints with Metal Magnetic Memory Testing Based on Tension-Compression Fatigue Test.

Metal magnetic memory testing (MMMT) is an effective nondestructive technique for fatigue damage monitoring of weldments because of its capacity for stress evaluation. An experimental investigation of the effect of the applied fatigue stress on MMMT signals, including the tangential component and the normal component , during tension-compression fatigue tests in welded joints was carried out systematically. The and signals at different fatigue cycles and fatigue stresses were collected and analyzed, and the results showed that there was a peak of and abnormal peaks of that existed at the welded joint before loading.

The effects of the oral administration of graphene oxide on the gut microbiota and ultrastructure of the colon of mice.

Background: Graphene oxide (GO) has been widely used in the field of biomedicine and has shown great potential in drug delivery. Oral administration is an important mode of administration, but there are few studies on the effects of oral GO on gastrointestinal tract and gut microbiota. This study sought to explore the effects of oral GO on the gastrointestinal tract and gut microbiota.

Graphene oxide induces autophagy and apoptosis via the ROS-dependent AMPK/mTOR/ULK-1 pathway in colorectal cancer cells.

To investigate the anticancer effects and action mechanism of graphene oxide (GO) in colorectal cancer (CRC). Anticancer effects and mechanisms of GO in CRC were investigated both and . GO significantly inhibited tumor growth both and .

Research on Atomic Oxygen Erosion Influence of Structural Damage and Tribological Properties of Mo/MoS-Pb-PbS Thin Film.

To investigate atomic oxygen effects on tribological properties of Mo/MoS-Pb-PbS film and further enlarge application range, atomic oxygen exposure tests were carried out for 5 h, 10 h, 15 h, and 20 h by the atomic oxygen simulator with atomic oxygen flux of 2.5 × 10 atoms/cm·s. The exposure time in test was equivalent to the atomic oxygen cumulative flux for 159.

Metal Complexes or Chelators with ROS Regulation Capacity: Promising Candidates for Cancer Treatment.

Reactive oxygen species (ROS) are rapidly eliminated and reproduced in organisms, and they always play important roles in various biological functions and abnormal pathological processes. Evaluated ROS have frequently been observed in various cancers to activate multiple pro-tumorigenic signaling pathways and induce the survival and proliferation of cancer cells. Hydrogen peroxide (HO) and superoxide anion (O) are the most important redox signaling agents in cancer cells, the homeostasis of which is maintained by dozens of growth factors, cytokines, and antioxidant enzymes.

Comammox activity dominates nitrification process in the sediments of plateau wetland.

The recent discovery of complete ammonia oxidation (comammox) has increased our understanding of nitrification. Although comammox has been shown to play an important role in plain wetland ecosystems, studies of comammox contribution are still limited in plateau wetland ecosystems. Here, we analyzed the abundance, activity, community and biogeochemical mechanisms of the comammox bacteria in Yunnan-kweichow and Qinghai-Tibet plateau wetlands from elevations of 1000-5000 m.

Effect of Q-Box size on liver stiffness measurement by two-dimensional shear wave elastography.

Purpose: To investigate the effect of the Q-Box size on liver stiffness (LS) measurement by two-dimensional shear wave elastography (2D SWE).

Methods: Ninety-eight patients with chronic liver disease were enrolled. Each patient was continuously measured five times.

Prediction of harmful algal blooms in large water bodies using the combined EFDC and LSTM models.

Harmful algal blooms (HABs) is a worldwide water environmental problem. HABs usually happens in short time and is difficult to be controlled. Early warning of HABs using data-driven models is prospective in making time for taking precaution against HABs.

Attenuating glucose metabolism by promotes Taxol sensitivity of colon cancer cells through downregulating oxidase 1 ().

Background: Colorectal cancer (CRC), one of the most common malignancies worldwide, is associated with poor survival and has a high mortality rate. Taxol is a chemotherapeutic agent that has been clinically applied as a first-line drug against diverse cancers. Yet, development of drug resistance has become the major challenge for anti-cancer treatments.

Downregulation of Ascl2 promotes cell apoptosis by enhancing autophagy in colorectal cancer cells.

Background: Colorectal cancer (CRC) is the third most common cancer, according to recently published literature. While the incidence and the mortality of CRC has decreased due to effective cancer screening measures, there has been an increase in the number of young patients diagnosed with colon cancer due to unclear reasons. As a target molecule of the Wnt signaling pathway, Ascl2 is an important marker of CRC stem cells and plays an important role in maintaining the nature of colon cancer stem/precursor cells.

Transanal minimally invasive surgery (TAMIS) for rectal tumor: a case report and literature review.

Transanal minimally invasive surgery (TAMIS) is mainly used for benign tumors of the rectum, but there are few reports on treating malignant tumors of the rectum with a large volume. The aim of this study was to evaluate the feasibility and safety of TAMIS for resection of rectal malignant tumors. A 57-year-old patient was pathologically diagnosed as rectal malignancy before surgery.