Low pH Means More Female Offspring: A Multigenerational Plasticity in the Sex Ratio of Marine Bivalves.

Global changes can profoundly affect the sex determination and reproductive output of marine organisms, disrupting the population structure and ecosystems. High COdriven low pH in the context of ocean acidification (OA) has been shown to severely affect various calcifiers, but less is known about the extent to which low pH influences sex determination and reproduction of marine organisms, particularly mollusks. This study is the first to report a biased sex ratio over multiple generations toward females, driven by exposure to high CO-induced low pH environments, using the ecologically and economically important Portuguese oyster () as a model.

ATRA-induced NEAT1 upregulation promotes autophagy during APL cell granulocytic differentiation.

Aims: Acute promyelocytic leukemia (APL) progresses quickly and often leads to early hemorrhagic death. Treatment with all-trans retinoic acid (ATRA) promotes differentiation of APL cells and clinical remission, making APL a potentially curable malignancy. Understanding how ATRA works may lead to new treatments for other types of leukemia.

Airway exposure to lithium nickel manganese cobalt oxide particles induces alterations in lung microenvironment and potential kidney and liver damage in mice.

With the increasing use of lithium-ion batteries, the exposure and health effects of lithium nickel manganate cobalt (NMC), a popular cathode material for the battery, have attracted widespread attention. However, the main absorption routes and target organs of NMC are unknown. This study aims to systematically investigate the main absorption routes and target organs of NMC.

Feasibility and safety of transvaginal natural orifice transluminal endoscopic surgery (V-NOTES) panhysterectomy: a polycentric retrospective study.

Objectives: To investigate the feasibility and safety of Transvaginal Natural Orifice Transluminal Endoscopic Surgery (V-NOTES) panhysterectomy.

Methods: A retrospective analysis was conducted on the data of 75 patients who underwent panhysterectomy for hysteromyoma in the Department of Obstetrics and Gynecology of Tongxiang Maternal and Child Health Hospital; Department of Gynecology, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University and Department of Gynecology, The First Affiliated Hospital of USTC from June 2019 to June 2020. According to the operation mode, the patients were divided into two groups: the traditional multi-port laparoscopic surgery (MPLS) group (n = 45) and the Transvaginal Natural Orifice Transluminal Endoscopic Surgery (V-NOTES) group (n = 30).

Novel functional hydrogels based on lignin‑silver nanoparticles with adhesion, antimicrobial, antioxidant and anti-freezing properties for wound dressings and pressure strain sensors.

As wound dressings and wearable electronics advance, it is critical to develop an efficacious strategy for integrating a variety of powerful functions into hydrogels. In this work, sodium lignosulfonate‑silver nanoparticles and the functional [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide structure (SBMA) are introduced into the multifunctional lignin-based hydrogel system. The sodium lignosulfonate‑silver nanoparticles, by catalyzing multiple redox reactions, facilitate the swift curing of hydrogels at room temperature.

Quantification of multi-pathway metabolites related to folate metabolism and application in natural population with MTHFR C677T polymorphism.

Folate, serving as a crucial micronutrient, plays an important role in promoting human growth and supporting transformations to a variety of metabolic pathways including one-carbon, pyrimidine, purine, and homocysteine metabolism. The 5,10-methylenetetrahydrofolate reductase (MTHFR) enzyme is pivotal in the folate metabolic pathway. Polymorphism in the MTHFR gene, especially C677T, was associated with decreased enzyme activity and disturbance of folate metabolism, which is linked to various diseases including birth defects in newborns and neural tube abnormalities.

Classification of Chicken Carcass Breast Blood-Related Defects Using Hyperspectral Imaging Combined with Convolutional Neural Networks.

For chicken carcass breast blood-related defects (CBDs), which occur with high frequency, the visual features are approximated in terms of the similarity of the composition of these defects, making it challenging to classify them, either manually or automatically, using conventional machine vision. The aim of this paper was to introduce a method of CBD classification based on hyperspectral imaging combined with Convolutional Neural Networks (CNNs). To process hyperspectral data, the Improved Firefly Band Selection Algorithm was constructed with the 1-D CNN CBD classification model as the objective function, achieving a reduction in the dimensionality of hyperspectral data.

Serum adipocytokines and inflammatory cytokines in pregnant women with gestational diabetes mellitus: clinical utility and development of a risk prediction model.

Background: This study analyzed the clinical utility of serum adipocytokines and inflammatory cytokines in gestational diabetes mellitus (GDM) and developed a quantitative nomogram prediction model.

Research Design & Methods: General data were collected. Fasting venous blood was taken and levels of fasting plasma glucose (FPG), serum adipocytokines, and inflammatory cytokines were assessed.

Mussel-Inspired Adhesive and Tough Composite Hydrogel Based on Polydopamine-Modified Nanocellulose for Strain and Wireless Sensing.

Adhesive composite hydrogels have received increasing attention in the fields of wearable sensors, electronic skin, and bioelectronic interfaces. However, combining good adhesiveness and high strength in a single composite hydrogel remains challenging. To address this issue, a polydopamine (PDA)-modified nanocellulose (PCNF)/polyacrylamide (PAM) composite hydrogel was developed, which exhibits good adhesiveness (40 kPa), good durability (1500 rpm), excellent frost resistance (-42 °C), and good sensitivity (GF = 1.

Manganese-doped carbon dots with catalase-like activity enable MRI-guided enhanced photodynamic therapy.

The tumor microenvironment (TME) exhibits characteristics such as hypoxia, weak acidity, and enrichment of glutathione and hydrogen peroxide (HO), which greatly limits the effectiveness of tumor magnetic resonance imaging (MRI) and photodynamic therapy (PDT). Carbon dots (CDs) nanozymes are excellent candidate materials with both diagnostic and therapeutic potential. However, CDs nanozymes with both ultra-high relaxation rate and good therapeutic effect are still to be developed.

Supplementation with Chinese herbal preparations protect the gut-liver axis of Hu sheep, promotes gut-liver circulation, regulates intestinal flora and immunity.

The gut-liver axis in ruminants can explain nutrient regulation, the gut-liver cycle, and immune function in ruminant biology through the gut microbe-gut metabolite-liver metabolite relationship. to investigate the effects of herbal feed additives on the gut-liver axis of Hu sheep. In this study, a broadly targeted UPLC-MS/MS metabolomics approach and 16s sequencing of gut microorganisms were used to detect, identify and quantify changes in ileal microorganisms, liver metabolites and ileal metabolites following the addition of Chinese herbal preparations.

The Multifaceted Ubiquitination of BIK1 During Plant Immunity in .

As sessile organisms, the plant immune system plays a vital role in protecting plants from the widespread pathogens in the environment. The (Arabidopsis) receptor-like cytoplasmic kinase BOTRYTIS-INDUCED KINASE1 (BIK1) acts as a central regulator during plant immunity. As such, not only the BIK1 protein accumulation but also the attenuation is tightly regulated to ensure effective immune responses.

[Construction and application of physical restraint reduction scheme for adult patients after cardiac surgery based on eCASH concept].

Objective: To construct a physical restraint reduction scheme based on eCASH concept (that is early Comfort using Analgesia, minimal Sedatives and maximal Human care for adult patients after cardiac surgery, and intervene, and to evaluate its effectiveness.

Methods: A non-synchronous case-control study was conducted. A total of 486 patients after cardiac surgery admitted to the cardiac surgery intensive care Unit (ICU) of Shandong Provincial Hospital Affiliated to Shandong First Medical University from July to October 2022 were enrolled as subjects.

Real-world clinical data-driven modelling on the initiation time of antiviral prophylaxis among pregnant women with chronic hepatitis B infection.

Background & Aims: The risk of mother-to-child transmission (MTCT) for pregnant women with chronic hepatitis B (CHB) infection still exists, especially for those with high HBV DNA level. The guidelines for initiating prophylaxis for pregnant women with CHB vary across countries. We aimed to explore the latest prophylaxis initiation time for these women.

Assessing the Performance of Artificial Intelligence Assistance for Prostate MRI: A Two-Center Study Involving Radiologists With Different Experience Levels.

Background: Artificial intelligence (AI) assistance may enhance radiologists' performance in detecting clinically significant prostate cancer (csPCa) on MRI. Further validation is needed for radiologists with different experiences.

Purpose: To assess the performance of experienced and less-experienced radiologists in detecting csPCa, with and without AI assistance.

Transcriptome Analysis of Chinese Cabbage Infected with Plasmodiophora Brassicae in the Primary Stage.

Clubroot disease caused by the infection of Plasmodiophora brassicae is widespread in China, and significantly reduces the yield of Chinese cabbage (Brassica rapa L. ssp. pekinensis).

A pH-responsive fluorescent film with the smartphone-assistance for real-time and visual detection of food freshness.

Monitoring food freshness is considerably important for food safety. In this study, a smart pH-responsive fluorescence hydroxypropyl methyl cellulose-κ-carrageenan-fluorescein isothiocyanate-NH-CaAlO (H-K-F-N) film was prepared. Taking synergetic advantage of the pH-dependent behavior of fluorescein isothiocyanate dye and the luminescence characteristics of calcium aluminate phosphor, the film exhibited a unique strong pH-responsive fluorescence with an exceptional linear relationship (correlation coefficient, R = 0.

Using nonlinear dynamics analysis to evaluate time response of cupping therapy with different intervention timings on reducing muscle fatigue.

Background: Cupping therapy has been indicated effective in reducing muscle fatigue after 24 h based on the spectral analyses of surface electromyography (sEMG). However, there is no sufficient evidence showing changes of sEMG nonlinear indexes at more time points after cupping therapy. Furthermore, it is unclear whether the intervention timings of cupping therapy affect the recovery from muscle fatigue.

A Robust Core-Shell Nanofabric with Personal Protection, Health Monitoring and Physical Comfort for Smart Sportswear.

Smart textiles with a high level of personal protection, health monitoring, physical comfort, and wearing durability are highly demanded in clothing for harsh application scenarios, such as modern sportswear. However, seamlessly integrating such a smart clothing system has been a long-sought but challenging goal. Herein, based on coaxial electrospinning techniques, a smart non-woven textile (Smart-NT) integrated with high impact resistance is developed, multisensory functions, and radiative cooling effects.

Late-Stage Modification of Peptides with Maleimides through Palladium-Catalyzed β-C(sp)-H Alkylation.

Transition-metal-catalyzed C-H activation has proven to be a powerful tool for the late-stage modification of peptides. We herein report a method for site-selective alkylation of peptides with maleimides through Pd-catalyzed β-C(sp)-H activation. In this protocol, the methionine residues within peptides serve as the directing groups, which circumvented the preinstallation and subsequent removal of the directing groups.