Facile Approach to Fabricating Stretchable Organic Transistors with Laser-Patterned Ag Nanowire Electrodes.

Stretchable electronics are poised to revolutionize personal healthcare and robotics, where they enable distributed and conformal sensors. Transistors are fundamental building blocks of electronics, and there is a need to produce stretchable transistors using low-cost and scalable fabrication techniques. Here, we introduce a facile fabrication approach using laser patterning and transfer printing to achieve high-performance, solution-processed intrinsically stretchable organic thin-film transistors (OTFTs).

Triple attention learning for classification of 14 thoracic diseases using chest radiography.

Chest X-ray is the most common radiology examinations for the diagnosis of thoracic diseases. However, due to the complexity of pathological abnormalities and lack of detailed annotation of those abnormalities, computer-aided diagnosis (CAD) of thoracic diseases remains challenging. In this paper, we propose the triple-attention learning (A Net) model for this CAD task.

Gustave Roussy Immune Score based on a three-category risk assessment scale serves as a novel and effective prognostic indicator for surgically resectable early-stage non-small-cell lung cancer: A propensity score matching retrospective cohort study.

Backgrounds: The Gustave Roussy Immune score (GRIm-Score) emerges as a novel prognostic scoring system for patient selection in phase I trials testing targeted immunotherapy for advanced-stage cancer. We tried to assess potential prognostic roles of preoperative GRIm-Score in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy for stage I-II non-small-cell lung cancer (NSCLC) by propensity score-matching (PSM) analysis.

Methods: This PSM-based analysis was performed on our single-center prospectively-maintained database between January 2014 and October 2015.

Functional coix seed protein hydrolysates as a novel agent with potential hepatoprotective effect.

The aim of this study is to explore the hepatoprotective potential of coix seed protein hydrolysates (CPP) against alcohol-induced liver injury, and investigate the underlying mechanisms. The hepatoprotective activity of CPP at 0, 10, 30, 50 mg per kg BW was demonstrated in vivo by using ICR male mice fed with 40% v/v alcohol (5 ml per kg body weight) daily to induce alcoholic liver injury. CPP could significantly improve the alcohol metabolism in liver as evidenced by the enhanced activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT).

Nischarin downregulation attenuates cell injury induced by oxidative stress via Wnt signaling.

Nischarin (NISCH) is a key protein functioning as a molecular scaffold and thereby hosting interactions with several protein partners. Here, we aimed to investigate whether NISCH downregulation could protect rat pheochromocytoma (PC12) cells against oxidative stress-induced injury using a model of cell injury induced by hydrogen peroxide (H2O2). Cell viability was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.

Shared and distinct global signal topography disturbances in subcortical and cortical networks in human epilepsy.

Epilepsy is a common brain network disorder associated with disrupted large-scale excitatory and inhibitory neural interactions. Recent resting-state fMRI evidence indicates that global signal (GS) fluctuations that have commonly been ignored are linked to neural activity. However, the mechanisms underlying the altered global pattern of fMRI spontaneous fluctuations in epilepsy remain unclear.

Rationale and design of a multicenter, randomized, patients-blinded two-stage clinical trial on effects of endothelial function test in patients with non-obstructive coronary artery disease (ENDOFIND).

Abnormal peripheral and coronary endothelial function has been associated with increased risk of major adverse cardiovascular events (MACE) in cross-sectional retrospective and observational studies. However, prognostic value of routine clinical evaluation, diagnosis and treatment of endothelial dysfunction on incident MACE in patients with non-obstructive coronary artery disease (NOCAD) remains unknown. Endothelial Function Guided Management in Patients with NOCAD (ENDOFIND) is a multicenter, randomized, patients-blinded, parallel-controlled, two-stage clinical trial evaluating the impact of routine clinical peripheral endothelial function testing on initiation and/or intensification of cardiovascular preventive therapies in Stage I, and on the risk of MACE in Stage II in patients with NOCAD.

Association of brain white matter lesions with arterial stiffness assessed by cardio-ankle vascular index. The Beijing Vascular Disease Evaluation STudy (BEST).

Unlabelled: Background-The association of brain white matter lesions with arterial stiffness, as assessed by the cardio-ankle vascular index, is not well characterized in the population.

Objective: The aim of this study was to quantify the cross-sectional association of brain white matter lesions with arterial stiffness assessed by the cardio-ankle vascular index among 1176 adults.

Methods: We used logistic regression to evaluate the associations of the cardio-ankle vascular index with brain white matter lesions, detected by computed tomography or magnetic resonance imaging, versus normal brain white matter.

Anion Intercalation into a Graphite Electrode from Trimethyl Phosphate.

Trimethyl phosphate (TMP) is a flame-retardant solvent frequently used in nonaqueous electric energy storage devices. Anions can hardly intercalate into a graphite positive electrode from neat TMP at ordinary conditions. In TMP solutions, dissolving lithium hexafluorophosphate (LiPF), lithium tetrafluoroborate (LiBF), lithium bis(fluorosulfonyl)imide (LiFSI), and lithium bis(trifluoromethanesulfonimide) (LiTFSI), by means of increasing lithium salt concentration or increasing the charge cutoff voltage of Li/graphite cells, the TMP-solvated anions can successfully intercalate into graphite positive electrodes.

Microbial community and function evaluation in the start-up period of bioaugmented SBR fed with aniline wastewater.

An enhanced sequencing batch reactor (SBR) system was developed to treat synthetic wastewater rich in 600 mg/L aniline. The aniline degradation efficiency was almost 100%, and the total nitrogen (TN) removal rate was more than 50%. Metagenomics technology revealed the community structure, functional genes and metabolic mechanism during the start-up of the enhanced reactor.

Meta-analysis of diagnostic performance of serology tests for COVID-19: impact of assay design and post-symptom-onset intervals.

Serology detection is recognized for its sensitivity in convalescent patients with COVID-19, in comparison with nucleic acid amplification tests (NAATs). This article aimed to evaluate the diagnostic accuracy of serologic methods for COVID-19 based on assay design and post-symptom-onset intervals. Two authors independently searched PubMed, Cochrane library, Ovid, EBSCO for case-control, longitudinal and cohort studies that determined the diagnostic accuracy of serology tests in comparison with NAATs in COVID-19 cases and used QUADAS-2 for quality assessment.

Computer-Aided System for the Detection of Multicategory Pulmonary Tuberculosis in Radiographs.

The early screening and diagnosis of tuberculosis plays an important role in the control and treatment of tuberculosis infections. In this paper, an integrated computer-aided system based on deep learning is proposed for the detection of multiple categories of tuberculosis lesions in chest radiographs. In this system, the fully convolutional neural network method is used to segment the lung area from the entire chest radiograph for pulmonary tuberculosis detection.

May Measurement Month 2018: an analysis of blood pressure screening results from China.

To further improve awareness, treatment, and control of hypertension, the May Measurement Month (MMM) campaign continued in 2018 in China. Study subjects were adults aged 18 years or more, ideally those who had not their blood pressure (BP) measured for at least a year. Blood pressure was measured three times consecutively with a 1-min interval in the sitting position, using automated BP monitors in 288 342 participants and transmitted to a central database by a smartphone app.

Poly(amino acid) Multilayers Modified Dendritic Mesoporous Silica Nanoparticles Achieve Effective Enzyme Stability for Ultrasensitive Immunoassay.

Enzyme-linked immunosorbent assay (ELISA) is one of the most common techniques in biomedical detection; however, the poor sensitivity in early diagnosis for some diseases seriously limits its application. In this work, we developed an ultrasensitive ELISA system that is based on horseradish peroxidase (HRP)-loaded dendritic mesoporous silica nanoparticles (DMSN) modified with poly(amino acid) multilayers (defined as DSHP). A large amount of HRP adsorption was achieved in center-radial mesoporous channels of DMSN because of the high specific surface area and large pore size, leading to significant signal amplification.

A Group-Based Community Reinforcement Approach of Cognitive Behavioral Therapy Program to Improve Self-Care Behavior of Patients With Type 2 Diabetes.

Introduction: This study evaluated a cognitive behavioral-based self-care intervention program on diabetes management in individuals with type 2 diabetes in Jiangsu Province, China. People with type 2 diabetes were recruited to a 6-month, prospective, intervention study.

Methods: The intervention group (n = 296) received an intensive cognitive behavioral-based self-care intervention, including group activities, frequent blood glucose monitoring, nutritional counseling, diabetes-specific meal and a weekly progress report.

sp. nov., a novel alginate lyase-producing marine bacterium.

A Gram-stain-variable, facultatively anaerobic, endospore-forming, rod-shaped bacterium, designated HB172198, was isolated from brown alga collected at Qishui Bay, Hainan, PR China. Phylogenetic analysis of 16S rRNA gene sequences indicated that strain HB172198 belonged to the genus , and the closest phylogenetically related species was NBRC 109972 (97.6% similarity).

Cooperation of Dimethyl and Diethyl Carbonates in Hexafluorophosphate Anion Intercalation into Graphite Electrode.

In dual-ion batteries, electrolyte solutions must comply with the positive electrodes of anion graphite intercalation compounds. The solutions of LiPF dissolved into ethylmethyl carbonate (EMC) cater to this need. In this paper, the mixtures of dimethyl carbonate (DMC) and diethyl carbonate (DEC) are employed in charge of EMC.

Drug-coated balloons used in peripheral artery disease: experience from a single center.

Objective: This retrospective single-center study aimed to analyze immediate and follow-up results of using drug-coated balloons (DCBs) for treating peripheral arterial disease.

Methods: In this study, we identified a total of 75 patients who underwent DCB therapy at our institution. The ankle-brachial index (ABI) was measured before and after intervention.

Naples Prognostic Score as a novel prognostic prediction tool in video-assisted thoracoscopic surgery for early-stage lung cancer: a propensity score matching study.

Backgrounds: The Naples Prognostic Score (NPS) emerges as a novel prognostic scoring system in surgical oncology. We aim to assess the prognostic significance of preoperative NPS in patients undergoing completely video-assisted thoracoscopic surgery (VATS) lobectomy for early-stage non-small cell lung cancer (NSCLC) by propensity score matching (PSM) analysis.

Methods: The present study was conducted on our single-center prospectively maintained database between January 2014 and December 2015.

Down-Regulation of miR-301a-3p Reduces Burn-Induced Vascular Endothelial Apoptosis by potentiating hMSC-Secreted IGF-1 and PI3K/Akt/FOXO3a Pathway.

Vascular endothelium dysfunction plays a pivotal role in the initiation and progression of multiple organ dysfunction. The mesenchymal stem cell (MSC) maintains vascular endothelial barrier survival via secreting bioactive factors. However, the mechanism of human umbilical cord MSC (hMSC) in protecting endothelial survival remains unclear.

Association between multi-site atherosclerotic plaques and systemic arteriosclerosis: results from the BEST study (Beijing Vascular Disease Patients Evaluation Study).

Background: Arteriosclerosis can be reflected in various aspect of the artery, including atherosclerotic plaque formation or stiffening on the arterial wall. Both arteriosclerosis and atherosclerosis are important and closely associated with cardiovascular disease (CVD). The aim of the study was to evaluate the association between systemic arteriosclerosis and multi-site atherosclerotic plaques.

A dual-ion battery has two sides: the effect of ion-pairs.

There is mutual interference between the positive and negative electrodes in a dual-ion battery. In LiTiO/graphite batteries, strong ion-pairs between Li and anions may have a detrimental effect on intercalation at both sides: Li into LiTiO, and anions into graphite.

Removal of Organic Micropollutants from Water by Macrocycle-Containing Covalent Polymer Networks.

Access to clean drinking water is a recognized societal need that touches on the health and livelihood of millions of people worldwide. This is providing an incentive to develop new water-treatment technologies. Traditional technologies, while widespread, are usually inefficient at removing organic pollutants from sewage or so-called grey water.

Author Correction: Role of intestinal trefoil factor in protecting intestinal epithelial cells from burn-induced injury.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Photocatalytic dual decarboxylative alkenylation mediated by triphenylphosphine and sodium iodide.

An efficient photocatalytic dual decarboxylative alkenylation of α,β-unsaturated carboxylic acids and alkyl N-hydroxyphthalimide (NHP) esters mediated by triphenylphosphine and sodium iodide has been developed. This protocol proceeds under 456-nanometer irradiation by visible blue light in the absence of transition metals or organic dye based photoredox catalysts. The reaction is successfully applied to a wide range of redox-active esters derived from aliphatic carboxylic acids (1°, 2° and 3°) and α-amino acids, enabling transformations of diverse α,β-unsaturated carboxylic acids to α,β-alkylated styrenes with high efficiency and excellent selectivity under mild conditions.