Effects of combined application of nitrogen, phosphorus, and potassium fertilizers on seed yield, seed quality and economic returns of Elymus nutans in alpine region.

The Qinghai-Tibetan Plateau (QTP), one of the most important ecological regions in the world, is experiencing a decline in ecological function as a result of severe grassland degradation. Elymus nutans is one of the ecological grass species for restoring degraded grasslands in QTP. The seed yield and seed quality are often limited by soil nutrients in QTP, so it is very important to optimize the application rates of fertilizer for E.

Midterm Outcomes of Common Femoral Patch Angioplasty in Iliofemoral Occlusive Diseases: Bovine Pericardial Patch versus Great Saphenous Vein Patch.

Objective: To assess the mid-term outcomes of utilizing bovine pericardium patch (BPP) compared to great saphenous vein patch (GSVP) in femoral angioplasty for iliofemoral occlusive diseases.

Methods: A retrospective study was carried out at the First Medical Center of the Chinese PLA General Hospital from January 2013 to July 2023 to assess the efficacy of femoral angioplasty in patients with iliofemoral occlusive disease. Technical success, early outcomes, 24-month primary patency, and freedom from restenosis at the patch site were evaluated.

Long-Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model.

Usher syndrome type 1C (USH1C) is a genetic disorder caused by mutations in the USH1C gene, which encodes harmonin, a key component of the mechanoelectrical transduction complex in auditory and vestibular hair cells. USH1C leads to deafness and vestibular dysfunction in humans. An Ush1c knockout (KO) mouse model displaying these characteristic deficits is generated in our laboratory.

Wnt signalling facilitates neuronal differentiation of cochlear Frizzled10-positive cells in mouse cochlea via glypican 6 modulation.

Degeneration of cochlear spiral ganglion neurons (SGNs) leads to irreversible sensorineural hearing loss (SNHL), as SGNs lack regenerative capacity. Although cochlear glial cells (GCs) have some neuronal differentiation potential, their specific identities remain unclear. This study identifies a distinct subpopulation, Frizzled10 positive (FZD10+) cells, as an important type of GC responsible for neuronal differentiation in mouse cochlea.

Near Full-Length Genomic Characterization of a Novel HIV-1 Unique Recombinant (A1/D/K) from an Immigrant Worker in China Using Nanopore Sequencing.

Recombination contributes substantially to the genetic diversity of HIV-1. Here we reported a novel HIV-1 recombinant detected from a Chinese labor who had been to Uganda as an immigrant worker using nanopore sequencing. Near full-length genome (NFLG) phylogenetic analysis showed that the novel HIV-1 recombinant HIV-sd1801 stood in a distinct branch between the CRF130_A1B/CRF131_A1B and CRF50_A1D/CRF84_A1D reference sequences.

A regional road network traffic noise limit prediction method based on design elements.

Since traffic flow has not been generated, a traffic noise prediction model based on actual traffic state data cannot be directly applied to the planned road network. Therefore, a regional traffic noise prediction method is proposed to find the upper limit of network noise emission based on design elements. The model is developed with noise predictions of the basic road section, interrupted/continuous intersections, and regional network.

Double-Dynamic-Bond Cross-Linked Hydrogel Adhesive with Cohesion-Adhesion Enhancement for Emergency Tissue Closure and Infected Wound Healing.

The hydrogel adhesives with strong tissue adhesion and biological characteristics adhm202404447are urgently needed for injury sealing and tissue repair. However, the negative correlation between tissue adhesion and the mechanical strength poses a challenge for their practical application. Herein, a bio-inspired cohesive enhancement strategy is developed to prepare the hydrogel adhesive with simultaneously enhanced mechanical strength and tissue adhesion.

Single-port non-lipolytic endoscopic surgery via the axillary approach for the treatment of benign breast tumors has better clinical outcomes: a case control study.

Background: Endoscopic surgery provides good cosmetic results while ensuring therapeutic outcomes. This study aimed to evaluate the efficacy, safety, and cosmetic outcome of endoscopic surgery for benign breast tumors.

Methods: In total, 108 patients were enrolled and divided into endoscopic or open surgery groups based on the patients' voluntary decisions.

Infinite Organic Solid-Solution Semiconductors with Continuous Evolution in Film Morphology, Crystalline Lattice and Electrical Properties.

Constructing a solid solution is an effective strategy for regulating the properties of composite organic semiconductors. However, there presents significant challenges in fabrication and understanding of organic solid-solution semiconductors. In this study, infinite solid-solution semiconductors are successfully achieved by integrating rod-like organic molecules, thereby overcoming the limitations of current organic composite semiconductors.

Burden of Liver Cancer Attributable to Hepatitis B and Alcohol Globally, in China, and for Five Sociodemographic Index Regions from 1990 to 2021: A Population-based Study.

Background And Aims: Liver cancer is a digestive system malignancy that poses a significant public health challenge globally. This study aimed to analyze and compare the epidemiological trends of liver cancer attributed to hepatitis B (LCHB) and alcohol use (LCAL) over the past 32 years.

Methods: Data on mortality and disability-adjusted life years for LCHB and LCAL in China, globally, and across five sociodemographic index regions were obtained from the Global Burden of Disease 2021 database and comprehensively analyzed.

Early Weaning Impairs the Growth Performance of Hu Lambs Through Damaging Intestinal Morphology and Disrupting Serum Metabolite Homeostasis.

This study aimed to evaluate the effect of early weaning (EW) on the growth performance, gastrointestinal development, serum parameters, and metabolomics of Hu sheep lambs. Twenty-four male Hu lambs were initially ewe-reared. A total of 12 lambs were weaned at 30 d of age (D30) as the EW group, and the remaining 12 lambs were weaned at 45 d of age (D45) as the control (CON) group.

Interaction Between Liver Metabolism and Gut Short-Chain Fatty Acids via Liver-Gut Axis Affects Body Weight in Lambs.

The gut-liver axis and its interactions are essential for host physiology. Thus, we examined the jejunal microbiota, fermentation parameters, digestive enzymes, morphology, and liver metabolic profiles in different growth development lambs to investigate the liver-gut axis's role in their development. One hundred male Hu lambs of similar birth weight and age were raised under the same conditions until they reached 180 days of age.

RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis.

Small GTPase RHEB is a well-known mTORC1 activator, whereas neddylation modifies cullins and non-cullin substrates to regulate their activity, subcellular localization and stability. Whether and how RHEB is subjected to neddylation modification remains unknown. Here, we report that RHEB is a substrate of NEDD8-conjugating E2 enzyme UBE2F.

Prognostic Value of Surgical Resection for Non-small-cell Lung Cancer Patients Comorbid With Minimal Pleural Effusion.

Background: The proportion and impact of minimal pleural effusion (PE) on prognosis remain blurred in operable non-small cell lung cancer (NSCLC) patients who reported minimal PE on imaging.

Methods: Clinical and prognostic data of operable NSCLC patients who presented no distant metastasis, no direct pleural invasion, but minimal PE on preoperative imaging were retrospectively analyzed. The patients were divided into surgical (81 cases) and non-surgical (10 cases) cohorts.

Intra-arterial Alteplase Thrombolysis After Successful Thrombectomy for Acute Ischemic Stroke in the Posterior Circulation (IAT-TOP): Study protocol and rationale.

Rationale: The Chemical Optimization of Cerebral Embolectomy (CHOICE) trial suggested that the administration of intra-arterial alteplase after successful endovascular thrombectomy (EVT) may improve neurological outcomes in patients with acute ischemic stroke due to large-vessel occlusion (AIS-LVO) in the anterior circulation. However, the use of adjunctive intra-arterial alteplase following successful EVT in acute posterior circulation stroke remains unexplored.

Aims: This study aims to investigate the efficacy and safety of intra-arterial alteplase after successful EVT for AIS-LVO in the posterior circulation.

Study on mechanical properties of sandstone damaged by blasting load under triaxial cyclic loading and unloading.

To investigate the changes in the strength and deformation of the blast load-damaged sandstone roof plate under cyclic loading and unloading conditions at different confining pressures, a triaxial loading device was used to carry out graded cyclic unloading tests on specimens with different degrees of damage, and the test results were summarized. The effects of blast-load-induced damage, confining pressure and loading stage on the strength, cohesion, internal friction angle, residual strain and volumetric strain were analyzed. (1) Compared with that of the undamaged specimen at a confining pressure of 0 MPa, the peak stress reductions in the vibration-damaged and blast-damaged specimens were 4.

Biocontrol mechanisms of antagonistic yeasts on postharvest fruits and vegetables and the approaches to enhance the biocontrol potential of antagonistic yeasts.

During storage and transportation, fruits and vegetables are susceptible to various pathogens, leading to quality degradation and significant economic losses. Currently, chemical pesticides are primarily used for control; however, their overuse poses serious threats to human health and causes environmental pollution. Biocontrol, known for its environmentally friendly characteristics, has been extensively studied.

Validation and evaluation of the performance of QIAstat-Dx gastrointestinal panel in pooled stool samples.

In the current study, the analytical sensitivity, analytical specificity, reproducibility, anti-interferences ability, and clinical performance of the QIAstat-Dx Gastrointestinal Panel (GIP) system were evaluated using pooled stool samples. Results showed that the pooled sample test detected the selected ten targets exclusively, with no cross reaction with any other targets of common enteropathogens. The analytical sensitivity of the pooled sample test on QIAstat-Dx GIP system was 10 CFU/ml for Shigella spp.

Disrupted NAD(P) Metabolism and Xanthine Dehydrogenase in a Stress-Induced Rat Model of Depression: NMR Metabolomics Insights.

: Clinical findings have shown a negative correlation between the severity of depressive symptoms and serum uric acid levels in men, yet the role of metabolic regulation in the pathophysiology of depression remains largely unknown. : In this study, we utilized an acute restraint-stress-induced male rat model of depression to investigate biochemical changes through NMR-based metabolomics combined with serum biochemical analysis. Additionally, we employed qPCR, immunoblotting, and enzyme activity assays to assess the expression and activity of xanthine oxidoreductase, the rate-limiting enzyme in uric acid production.

[Adverse Effects and Underlying Mechanisms of Soil Microplastics on Crops and Its Preventive Strategies].

Microplastics （MPs）, as a type of emerging environmental pollutant with a particle size < 5 mm, have been frequently detected in environmental matrices. MPs pollution in soils has been attracting the scientific community due to the increasing contaminant areas and continuous accumulation, leading to a high risk to crop production. In addition, recent studies have observed that long-term exposure to MPs could seriously harm the soil ecosystem because of their fine particle size and persistence in soils.

A cross-linked coating loaded with antimicrobial peptides for corrosion control, early antibacterial, and sequential osteogenic promotion on a magnesium alloy as orthopedic implants.

Magnesium (Mg)-based alloys have been recognized as desirable biodegradable materials for orthopedic implants. However, their clinical application has been limited by rapid degradation rates, insufficient antibacterial and osteogenic-promotion properties. Herein, a MgF priming layer was first constructed on AZ31 surface.

A sandwich-type electrochemiluminescence biosensor based on Ni(HAB)/Au@ZnNiAl-LDH/Ru@MIL-53(Al)-NH for ultra-sensitive detection of microRNA-155.

A novel electrochemiluminescence (ECL) biosensor was developed for the ultrasensitive detection of miRNA-155, based on the synergistic combination of multifunctional nanomaterials. The biosensor employed a conductive metal-organic framework (MOF), Ni(HAB) (HAB = hexaaminobenzene), as the substrate material. The unique π-electron conjugated structure of Ni(HAB) endowed the biosensor with excellent electron transport properties, significantly enhancing its sensitivity.

Complications and patient-reported outcomes after radiotherapy in breast cancer patients undergoing implant-based breast reconstruction: a retrospective study from a large Chinese breast disease center.

Background: Postmastectomy radiation therapy (PMRT) can influence the outcome of implant-based breast reconstruction (IBBR). This study aims to investigate the complications and patient-reported outcomes (PROs) following PMRT between direct-to-implant (DTI) and tissue expander-to-implant (TEI) reconstruction.

Methods: The retrospective study included breast cancer patients undergoing IBBR and PMRT.