Hemin attenuates bleomycin-induced lung fibrosis in mice by regulating the TGF-β1/MAPK and AMPK/SIRT1/PGC-1α/HO-1/NF-κB pathways.

The objective of this study was to investigate the protective effect and potential mechanism of action of hemin on bleomycin-induced pulmonary fibrosis in mice. Male C57BL/6 mice were randomly divided into control, bleomycin and bleomycin + hemin groups. Mice in the bleomycin and bleomycin + hemin groups were injected intratracheally with bleomycin to establish the pulmonary fibrosis model.

Deletion of protein kinase C θ attenuates hepatic ischemia/reperfusion injury and further elucidates its mechanism in pathophysiology.

Objectives: Hepatic ischemia-reperfusion (HIR) is a severe process in pathophysiology that occurs clinically in hepatectomy, and hepatic transplantations. The present study aimed to investigate the effect of PKC θ deletion against HIR injury and elucidate its mechanism in pathophysiology.

Materials And Methods: HIR injury was induced in wild-type and PKC θ deletion mice treated with or without heme.

Mechanistic characterization of dissolved inorganic phosphorus in water during the red tide.

The eutrophication of water, such as excessive nitrogen and phosphorus, are closely associated with the outbreak of red tide. However, the response of dissolved inorganic phosphorus (DIP) to red tide remained unclear in water. In this study, three species of diatoms capable of causing red tides were cultured in simulated seawater with different concentrations of DIP.

Legacy and emerging per- and polyfluoroalkyl substances (PFASs) in agricultural soils affected by fluorochemical manufacturing facilities, North China: Occurrence, region-specific distribution, substitution trend and source appointment.

Accompanied with restriction of legacy per- and polyfluoroalkyl substances (PFASs), numbers of emerging PFASs are widely detected in the environment. However, information on environmental occurrences and behaviors of emerging PFASs were scarce in agricultural soils. In this study, the spatial distributions, sources, substitution trends and ecological risk assessment of 31 legacy and emerging PFASs were investigated in 69 agricultural soils from Fuxin, North China.

CPXM1 correlates to poor prognosis and immune cell infiltration in gastric cancer.

Background: Gastric cancer (GC) is the fourth most common cause of cancer-related death and the fifth most frequent malignant cancer, especially advanced GC. Carboxypeptidase X member 1 (CPXM1) is an epigenetic factor involved in many physiological processes, including osteoclast differentiation and adipogenesis. Several studies have shown the association of CPXM1 with multiple tumors; however, the mechanism of CPXM1 involvement in the progression of GC is yet to be characterized.

Disclosing phototransformation mechanisms of decabromodiphenyl ether (BDE-209) in different media by simulated sunlight: Implication by compound-specific stable isotope analysis.

As one of the typical brominated flame retardants, decabromodiphenyl ether (BDE-209) has been widely detected in environment. However, scarce information was available on BDE-209 phototransformation mechanisms in various media. In this study, compound-specific stable isotope analysis was first applied to investigate BDE-209 phototransformation in n-hexane, MeOH:HO (v:v, 8:2), and simulated seawater by simulated sunlight.

Systematic characterization of the influence of petroleum spill on terpene metabolism in Suaeda salsa (L.) Pall from coastal wetland: Implication by compound-specific stable isotope.

With the increasing industrialization and urbanization, the ecological environment is suffering from severe deterioration in Liaohe coastal wetland, and petroleum spill is one of the pollution sources. Suaeda salsa (L.) Pall (S.

Novel Chemo-Photothermal Therapy in Hepatic Cancer Using Gemcitabine-Loaded Hyaluronic Acid Conjugated MoS/ZnO Nanocomposites.

Hepatocellular carcinoma is a serious illness with a high rate of mortality. A high dose of theranostic drugs with efficient diagnostic and therapeutic capabilities should be required. Chemo-photothermal therapy is presently recognized as a secure method of cancer treatment that specifically targets tumour tissue or cells.

Emerging and legacy per- and polyfluoroalkyl substances in Daling River and its estuary, Northern China.

Strict restriction on legacy per- and polyfluoroalkyl substances (PFASs) has caused a dramatic increase in production and usage of emerging PFASs over the last decades. However, the environmental behaviors of emerging PFASs is largely unknown in Daling River, Northern China. In this study, the potential sources, sediment-water partitioning and substitution trends of PFASs were investigated in overlying water and sediments from Daling River and its estuary.

Disclosing the effect of exogenous betaine on growth of Suaeda salsa (L.) Pall in the Liaohe coastal wetland, North China.

Liaohe coastal wetland has experienced severe degradation of Suaeda salsa (L.) Pall (S. salsa) in recent years.

Novel Insights into Uptake, Translocation, and Transformation Mechanisms of 2,2',4,4'-Tetra Brominated Diphenyl Ether (BDE-47) in Wheat ( L.): Implication by Compound-Specific Stable Isotope and Transcriptome Analysis.

The uptake, translocation, and transformation of 2,2',4,4'-tetra brominated diphenyl ether (BDE-47) in wheat ( L.) were comprehensively investigated by hydroponic experiments using compound-specific stable isotope analysis (CSIA) and transcriptome analysis. The results indicated that BDE-47 was quickly adsorbed on epidermis of wheat roots and then absorbed in roots via water and anion channels as well as an active process dependent on energy.

Lycopene improves autophagy and attenuates carbon tetrachloride-induced hepatic fibrosis in rats.

Aim: To evaluate the effect of lycopene on carbon tetrachloride (CCl4)-induced hepatic fibrosis and elucidate the underlying mechanism.

Methods: Male rats were randomly assigned to the control group, CCl4 group, and lycopene group. The CCl4 group was intraperitoneally injected with CCl4 twice per week for 12 weeks to induce hepatic fibrosis.

Apolipoprotein C1 promotes tumor progression in gastric cancer.

Background: Gastric cancer (GC) is a malignancy with the worst prognosis that seriously threatens human health, especially in East Asia. Apolipoprotein C1 () belongs to the apolipoprotein family. In addition, has been associated with various tumors.

Mechanistic characterization of anaerobic microbial degradation of BTBPE in coastal wetland soils: Implication by compound-specific stable isotope analysis.

As a novel brominate flame retardants, 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) has been extensively used in various consumer products, and frequently detected in various environmental matrices. However, the microbial degradation of BTBPE remains unclear in the environment. This study comprehensively investigated the anaerobic microbial degradation of BTBPE and therein stable carbon isotope effect in the wetland soils.

Systematic characterization of sediment microbial community structure and function associated with anaerobic microbial degradation of PBDEs in coastal wetland.

As the widely used flame retardant, polybrominated diphenyl ethers (PBDEs) have been ubiquitously detected in wetland sediments. Microbial degradation is the importantly natural attenuation process for PBDEs in sediments. In this study, the microbial degradation of PBDEs and inherent alternation of microbial communities were explored in anaerobic sediments from coastal wetland, North China.

Riboflavin ameliorates mitochondrial dysfunction via the AMPK/PGC1α/HO‑1 signaling pathway and attenuates carbon tetrachloride‑induced liver fibrosis in rats.

Hepatic fibrosis is a global health problem, with increasing evidence demonstrating that oxidative stress serves a pivotal role in fibrogenesis. Riboflavin is a vital nutrient in the human and animal diet, which enhances the activity of antioxidant enzymes and ameliorates oxidative stress. The present study evaluated the effect of riboflavin on liver fibrosis and the mechanisms underlying this process.

A Facile Pre-Lithiated Strategy towards High-Performance LiSe-LiTiO Composite Cathode for Li-Se Batteries.

Conventional lithium-ion batteries with a limited energy density are unable to assume the responsibility of energy-structure innovation. Lithium-selenium (Li-Se) batteries are considered to be the next generation energy storage devices since Se cathodes have high volumetric energy density. However, the shuttle effect and volume expansion of Se cathodes severely restrict the commercialization of Li-Se batteries.

Application of dual carbon-bromine stable isotope analysis to characterize anaerobic micro-degradation mechanisms of PBDEs in wetland bottom-water.

Polybrominated diphenyl ethers (PBDEs), one kind of persistent organic pollutants, were widely detected in coastal wetlands. Microbial reductive debromination is one of the most important attenuation processes for PBDEs in anaerobic environment, whereas the underlying reaction mechanisms remain elusive. Dual-element stable isotope analysis was recently recognized to distinguish different reaction mechanism for degradation of organic pollutants.

Knockout of PKC θ gene attenuates oleic acid-induced acute lung injury via reduction of inflammation and oxidative stress.

Objectives: Acute respiratory distress syndrome resulting from acute lung injury has become a momentous clinical concern because of high morbidity and mortality in discharged patients with pulmonary and nonpulmonary diseases. This study aimed to explore the effect of protein kinase C (PKC) θ gene knockout on acute lung injury.

Materials And Methods: Wt and PKC θ gene knockout mice were intravenously injected with oleic acid to induce acute lung injury.

Construction of Novel lncRNA-miRNA-mRNA Network Associated With Recurrence and Identification of Immune-Related Potential Regulatory Axis in Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is one of the most common malignant diseases globally. Despite continuous improvement of treatment methods, high postoperative recurrence rate remains an urgent problem. In order to determine the mechanism underlying recurrence of liver cancer and identify prognostic genes, data from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) were integrated and analyzed.

Effects of excessive nitrogen on nitrogen uptake and transformation in the wetland soils of Liaohe estuary, northeast China.

It remains unclear whether excessive nitrogen additions lead to the degradation of Suaeda salsa (S. salsa) by affecting the nitrogen pool, enzyme activities, and bacterial community structure of wetland soils. This study investigated the effect of five added nitrogen concentrations (0, 1, 2, 4, and 6 mmol L N with NHNO = group C, group L, group M, group H, and group G, respectively) on nitrogen uptake by S.

Mortalin/glucose-regulated protein 75 promotes the cisplatin-resistance of gastric cancer via regulating anti-oxidation/apoptosis and metabolic reprogramming.

Platinum drug treatment is one of the most predominant chemotherapeutic strategies for patients with gastric cancer (GC). However, the therapeutic effect is less than satisfactory, largely due to the acquired resistance to platinum drugs. Therefore, a better understanding of the underlying mechanisms can greatly improve the therapeutic efficacy of GC.