Publications by authors named "Wang Guo-Hua"

Gastric cancer remains a major global health challenge with high morbidity and mortality rates. Recent advancements in immunology and inflammation research have highlighted the crucial roles that these biological processes play in tumor progression and patient outcomes. This has sparked new interest in developing prognostic biomarkers that integrate these two key biological processes.

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Background: The early diagnosis and treatment of Heliobacter pylori (H.pylori) gastrointestinal infection provide significant benefits to patients. We constructed a convolutional neural network (CNN) model based on an endoscopic system to diagnose H.

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High-altitude polycythemia (HAPC) affects individuals living at high altitudes, characterized by increased red blood cells (RBCs) production in response to hypoxic conditions. The exact mechanisms behind HAPC are not fully understood. We utilized a mouse model exposed to hypobaric hypoxia (HH), replicating the environmental conditions experienced at 6000 m above sea level, coupled with in vitro analysis of primary splenic macrophages under 1% O to investigate these mechanisms.

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We investigated the changes of soil nutrients and plant communities in the artificial sand fixation forests of with different ages. The results showed that soil organic carbon and soil total nitrogen contents increased with the stand ages, and were significantly higher in 40 and 50 year-old than other ages. Soil organic carbon and total nitrogen contents recovered much faster in the surface layer (0-10 cm) than in others.

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Objective: This study was designed to investigate the role of 8-oxoguanine DNA glycosylase 1 (OGG1) in preventing atherosclerosis-induced vascular EC injury, thereby providing a theoretical basis for the exploration of drug targets and treatment methods for atherosclerosis.

Methods: Human umbilical vein cell line (EA.hy926) was treated with ox-LDL to construct an in vitro atherosclerotic cell model.

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Article Synopsis
  • - The study examined how adding specific microbial consortia enhanced the cleanup of uranium-contaminated groundwater through processes like bioreduction and biomineralization, with two experimental groups testing reducing and phosphate-solubilizing functions.
  • - The addition of β-glycerophosphate spurred microbial growth and improved key functional microbes in both experimental groups, leading to significantly higher rates of uranium removal and the formation of U-phosphate precipitates compared to a control group.
  • - Notably, the reducing consortium in one group facilitated the conversion of U(VI) to a less toxic form, U(IV), illustrating that bioaugmentation effectively accelerates uranium remediation in contaminated sites.
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The histone methyltransferase enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2)-mediated trimethylation of histone H3 lysine 27 (H3K27me3) regulates neural stem cell proliferation and fate specificity through silencing different gene sets in the central nervous system. Here, we explored the function of EZH2 in early post-mitotic neurons by generating a neuron-specific Ezh2 conditional knockout mouse line. The results showed that a lack of neuronal EZH2 led to delayed neuronal migration, more complex dendritic arborization, and increased dendritic spine density.

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Purpose: To explore the feasibility of adhesive thiomer calcium alginate composite hydrogel (ZIF-8@CHA-SH) containing metal-organic framework for the treatment of periodontitis in rats.

Methods: Preparation and characterization of ZIF-8@CHA-SH were performed, and the morphology and chemical composition were observed. The antibacterial properties were detected by plate coating method and scanning electron microscope.

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Article Synopsis
  • - The study investigates how glioma-associated endothelial cells (GAEs) interact with glioma cells and their role in tumor growth and blood vessel formation.
  • - Results show that glioma subtypes differ in GAE levels, and higher GAE abundance is linked to worse outcomes for patients.
  • - Anti-VEGF therapy can reduce GAE's effects on gliomas and increase IL-2 levels, which can help decrease glioma cell invasion driven by GAEs.
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We investigated the morphological characteristics of seeds with three different sizes under plantations with different stand ages (6, 12, 18, 40 and 50 years old) in the typical sandy-hilly region of northwest Shanxi Province, to explore the restoration potential of artificial vegetation from the perspective of reproduction strategies. The results showed that seed production of plantation increased with stand age, reaching the maximum (584 grain·plant) in 50-year-old stand. Seed length, seed width, and seed shape index decreased with stand age, reaching the minimum (5.

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Article Synopsis
  • The study investigated the impact of skull defects on rats to understand the effects on brain function and underlying mechanisms.
  • Researchers created skull defects of various sizes and evaluated behavioral changes, noting that sensory function was impaired by day 6 and motor function by day 2 after creating a 5 × 10 mm defect.
  • Key findings included increased levels of apoptosis and autophagy markers in the damaged brain area, alongside a decline and eventual recovery of blood flow in the internal carotid artery, indicating that larger skull defects could affect cognitive function due to reduced cerebral blood flow.
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DL-3-n-butylphthalide (NBP)-a compound isolated from Apium graveolens seeds-is protective against brain ischemia via various mechanisms in humans and has been approved for treatment of acute ischemic stroke. NBP has shown recent potential as a treatment for Parkinson's disease. However, the underlying mechanism of action of NBP remains poorly understood.

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The stability of internal reference genes is crucial to the reliability of gene expression results using real-time fluorescence quantitative PCR (qRT-PCR). Inappropriate reference genes may lead to inaccurate results or even wrong conclusions. This study aims to identify stable reference genes for analyzing the expression of proliferation-related and differentiation-inducing genes in bovine primary preadipocytes (BPPs) in vitro.

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The accuracy of sixteen commonly used internal reference genes was assessed in skeletal muscle-derived satellite cells of Qinchuan cattle at different stages of proliferation and induction of differentiation to determine the most suitable ones. Quantitative real-time PCR and three commonly used algorithmic programs, GeNorm, NormFinder and BestKeeper, were used to evaluate the stability of expression of the candidate internal reference genes (GAPDH, ACTB, PPIA, LRP10, HPRT1, YWHAZ, B2M, TBP, EIF3K , RPS9, UXT, 18S rRNA, RPLP0, MARVELD, EMD and RPS15A) in skeletal muscle-derived satellite cells at 0, 12, 24, 36 and 48 h of growth and after differentiation for 0, 2, 4, 6 and 8 days. The expression of two satellite cell marker genes, CCNA2 and MYF5, was used for validation analysis.

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Objectives: The prognostic value of fluid-attenuated inversion recovery vessel hyperintensity (FVH) remains controversial in acute ischemic stroke (AIS). The objective was to investigate whether the presence of FVH could predict long-term functional outcomes in patients with AIS receiving medical therapy.

Methods: Consecutive AIS patients with anterior circulation large vessel stenosis (LVS) in multiple centers between January 2019 and December 2020 were studied.

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In the field of genome assembly, contig assembly is one of the most important parts. Contig assembly requires the processing of overlapping regions of a large number of DNA sequences and this calculation usually takes a lot of time. The time consumption of contig assembly algorithms is an important indicator to evaluate the degree of algorithm superiority.

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Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and associated with adverse pregnancy outcomes. The aim of this study was to investigate the changes of lipoprotein-associated phospholipaseA2 (Lp-PLA2) level and its correlation with biochemical indexes in patients with GDM.This observational cross-sectional study was performed among 52 GDM and 48 healthy pregnant women.

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Distilling Knowledge by Mimicking Features.

IEEE Trans Pattern Anal Mach Intell

November 2022

Knowledge distillation (KD) is a popular method to train efficient networks ("student") with the help of high-capacity networks ("teacher"). Traditional methods use the teacher's soft logits as extra supervision to train the student network. In this paper, we argue that it is more advantageous to make the student mimic the teacher's features in the penultimate layer.

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The sandy-hilly region of northwest Shanxi is a typical fragile agro-pastoral ecotone in north China. With the artificial at 0 (the uncultivated land), 6, 12, 18, 40 and 50 years-old in the typical sandy-hilly region of northwest Shanxi as the subjects, we investigated soil moisture, aboveground and belowground biomass, individual morphological characteristics, growth, reproduction, and photosynthetic physiological characteristics of different-aged , with the aim to evaluate the long-term growth and reproductive dynamic characteristics of artificial The results showed that soil moisture was significantly affected by stand ages. Soil moisture was low under the 6-year-old plantation.

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Objective: We attempt to investigate the biological function of the discoidin, complement C1r/C1s,Uegf, and Bmp1 and Limulus factor C, Coch, and Lgl domain-containing 2 (DCBLD2) in glioblastoma, as well as its effect on the epithelial-mesenchymal transition (EMT) process.

Methods: The public expression data of glioblastoma samples and normal brain samples from The Cancer Genome Atlas database, Genotype-Tissue Expression database and Chinese Glioma Genome Atlas database were used to analyze the expression of DCBLD2 and its relationship with the survival of patients with glioblastoma. Quantitative real-time PCR and western blot were used to evaluate mRNA and protein levels of DCBLD2.

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This study attempted to research the molecular mechanism underlying the inhibitory role of miR-1225-5p in the malignant progression of glioblastoma. Bioinformatics analyses based on the gene expression omnibus (GEO) and Chinese glioma genome atlas (CGGA) databases showed that miR-1225-5p, as a favorable prognostic factor, was expressed at low levels in glioblastoma, and its expression was also related to WHO grade and age. The subsequent CCK-8 assay indicated that miR-1225-5p might prevent the malignant progression of glioblastoma, which was represented by that miR-1225-5p mimic reduced the viability of glioblastoma cells.

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Prevalence of postpartum depression (PD) in Chinese women is rising and its associated factors are not well known. In this study we aim to explore the associations between nutritional factors in pregnancy and the risk of PD in Chinese women.A case-control study was performed in our hospital during January 2016 to June 2019.

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We assessed the effects of different concentrations of salts (0, 40, 80, 120, 160 and 200 mmol·L) on the seed germination and re-germination of six typical annuals (Gramineae: Setaria viridis, Chloris virgata and Eragrostis minor; Chenopodiaceae: Bassia dasyphylla, Salsola ruthenica and Corispermum mongolicum) in autumn of current year and next spring, with NaCl and NaHCO as neutral sodium salt and alkaline sodium salt. The results showed that NaCl and NaHCO significantly affected seed germination of the six species. The inhibition effect of NaHCO on seed germination was stronger than NaCl.

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It has been identified that arginine vasopressin (AVP), vasopressin receptor 2(V2R), and the aquaporin 2 (AQP2) signaling pathway in the inner ear play important roles in hearing and balance functions through regulating the endolymph equilibrium; however, the contributions of this signaling pathway to the development of motion sickness are unclear. The present study was designed to investigate whether the activation of the AVP-V2R-AQP2 signaling pathway in the inner ear is involved in the induction of motion sickness and whether mozavaptan, a V2R antagonist, could reduce motion sickness. We found that both rotatory stimulus and intraperitoneal AVP injection induced conditioned taste aversion (a confirmed behavioral index for motion sickness) in rats and activated the AVP-V2R-AQP2 signaling pathway with a responsive V2R downregulation in the inner ears, and AVP perfusion in cultured epithelial cells from rat endolymphatic sacs induced similar changes in this pathway signaling.

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Introduction: When humans breathe compressed air or N-O mixtures at three to four atmospheres pressure, they will experience nitrogen narcosis that may possibly lead to a diving accident, but the underlying mechanisms remain unclear.

Methods: Mice were exposed to 1.6 MPa breathing a N-O mixture adjusted to deliver an inspired PO of 32-42 kPa.

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