Impact of serum retinol-binding protein 4 levels in late pregnancy on the incidence of small/large for gestational age infants among 11,854 pregnant women: A retrospective study.

Background: There is still uncertainty regarding the association between maternal serum levels of retinol-binding protein 4 (RBP4) and pregnancy outcomes. This study aimed to determine the association between RBP4 levels and incidence of small/large for gestational age (SGA/LGA) infants among the Chinese population.

Methods: This was a retrospective study of 11,854 pregnant women who delivered at Changzhou Maternal and Child Health Care Hospital between 2016 and 2017 and whose serum RBP4 levels were measured at the time of admission.

Targeting TRAF6/IRF3 axis to inhibit NF-κB-p65 nuclear translocation enhances the chemosensitivity of 5-FU and reverses the proliferation of gastric cancer.

Chemoresistance poses a significant clinical challenge in the treatment of gastric cancer (GC), while its underlying molecular mechanisms are still not fully understood. Post-translational protein modification and abnormal activation of nuclear factor-kappa B (NF-κB) are critical regulators of tumor chemoresistance. This study investigates the role of TNF receptors-associated factors 6 (TRAF6) in 5-Fluorouracil (5-FU) resistant GC.

Optimal parameter setting and evaluation for ultraviolet-assisted direct ink writing bioprinting of nHA/PEGDA scaffold.

Ultraviolet-assisted Direct Ink Writing（UV-DIW）, an extrusion-based additive manufacturing technology, has emerged as a prominent 3D printing technique and is currently an important topic in bone tissue engineering research. This study focused on the printability of double-network (DN) bioink (Nano-hydroxyapatite/Polyethylene glycol diacrylate(nHA/PEGDA)). Next, we search for the optimal UV-DIW printing parameters for the scaffold formed by nHA-PEGDA.

Plasma catalytic ammonia synthesis in a fluidized-bed DBD reactor over M/AlO: Enhancement of plasma-catalyst surface interaction.

Ammonia is a promising alternative energy to fossil fuels for reducing CO emissions. Plasma catalysis technology for ammonia production using clean energy is gaining attention. Introducing catalysts to the plasma increases ammonia synthesis rates, but the effect of catalyst particle movement in the plasma region, such as in a fluidized-bed reactor, is less explored.

Spatial pattern of critical wetland patches and its influencing factors in a coastal area, North China.

Knowing the spatial pattern of critical wetland patches has an important significance for the restoration and protection of wetland ecosystems. However, the spatial pattern of critical wetland patches in coastal areas is not well understood, and its influencing factors are also unclear, especially in coastal areas. In this study, landscape indices were used to study the spatial pattern of the wetlands in the Hebei-Tianjin coastal area, North China.

Global and Regional Burden of Ischemic Stroke Disease from 1990 to 2021: An Age-Period-Cohort Analysis.

Ischemic stroke is a significant global public health issue that impacts health burdens across various regions. This study analyzed data from the Global Burden of Disease Study 2021 to assess the incidence, mortality, and disability-adjusted life years (DALYs) associated with ischemic stroke worldwide and across different Socio-demographic Index (SDI) regions. Using joinpoint regression and age-period-cohort (APC) models, we examined trends in disease burden and made projections for 2022 to 2035.

Aggregation-Induced Emission Luminogens for Plant Photodynamic Seed Sterilization.

Pathogen-carrying seeds can significantly impact plant growth and development and may lead to serious public health incidents. Modern agriculture heavily relies on synthetic chemical microbicides and physical methods to eradicate pathogens transmitted by plant seeds. To counteract the misuse of microbicides, a class of cationic amphiphilic aggregate-induced emission luminogens (AIEgens) are developed as photodynamic seed sterilization agents.

Similarities in distribution pattern between acute multiple osteoporotic vertebral compression fractures and vertebral fractures cascades.

Backgroud: Osteoporotic vertebral compression fractures (OVCF) cascades (OVCFcs) repeatedly cause vertebral compression to involve multiple vertebra. This study aimed to introduce an accelerated form of OVCFcs: acute multiple OVCF (amOVCF).

Methods: OVCF patients with multiple vertebral augmentations in a spine center between June 2016 and October 2020 were retrospectively studied.

Parental health belief model constructs associated with oral health behaviors, dental caries, and quality of life among preschool children in China: a cross-sectional study.

Background: Early childhood caries (ECC) is a prevalent health problem that negatively affects both overall health and oral health-related quality of life (OHRQoL). This study investigated the association between health belief model (HBM) constructs and oral health behaviors, dental caries, and OHRQoL in preschool children in China.

Methods: A total of 1562 preschool children aged 3 to 6 years were recruited from six public kindergartens in Hangzhou, Zhejiang Province, by using stratified cluster sampling.

Therapeutic Efficacy of a Synthetic Brain-Targeted HS Donor Cross-Linked Nanomicelle in Autism Spectrum Disorder Rats through Aerobic Glycolysis.

Autism spectrum disorder (ASD) is characterized by cognitive inflexibility and social deficits, with a notably limited range of brain-targeted medications, particularly in the field of nanomedicine. Herein, we introduce the brain-targeted HS donor cross-linked nanomicelle, named mannose-PEG600-lipoic acid (Man-LA). Man-LA demonstrates enhanced stability and precise brain delivery by interacting with glucose transporter 1 (GLUT1) in astrocytes, facilitating a gradual release of HS that is modulated by glutathione (GSH).

Anti-Site Defect-Induced Cascaded Sub-Band Transition in CuInS Enables Infrared Light-Driven CO Reduction.

Photocatalytic CO conversion is a promising approach to simultaneously mitigate climate change and alleviate the energy crisis. However, infrared light, which constitutes nearly half of the solar energy, has not been effectively utilized yet. In this work, we discover a photogenerated charge transition mechanism in CuInS with intrinsic In antisite defects for synergistic utilization of full-spectrum photons.

An antibiotic that mediates immune destruction of senescent cancer cells.

Drugs that eliminate senescent cells, senolytics, can be powerful when combined with prosenescence cancer therapies. Using a CRISPR/Cas9-based genetic screen, we identify here SLC25A23 as a vulnerability of senescent cancer cells. Suppressing SLC25A23 disrupts cellular calcium homeostasis, impairs oxidative phosphorylation, and interferes with redox signaling, leading to death of senescent cells.

Endovascular thrombectomy: an effective and safe therapy for perioperative ischemic stroke.

Background: Perioperative ischemic stroke is a rare but devastating complication. Mechanical thrombectomy is a promising therapeutic method, but very little data is available on its efficacy and safety. This study aims to answer this question by comparing the clinical outcomes of perioperative and community-onset stroke patients after endovascular therapy.

Discovery of Potential Candidate Genes for Coat Colour in Wuzhishan Pigs by Integrating SNPs and mRNA Expression Analysis.

Despite identifying genes regulating the coat colour in Western pig breeds, the genetic basis of the coat colour in Chinese indigenous pigs is still not understood due to the diversity of indigenous breeds and their genetic differences from exotic pigs. In this study, 215 Wuzhishan pigs with three coat colour patterns (white, black, and black-back/white-belly) were used to conduct a genome-wide association analysis. We found that genes responsible for the coat colour in the Wuzhishan breed are located on chromosome 8.

Ga-PSMA PET/CT-Based Model Predicts Perineural Invasion of Prostate Cancer with Whole-Mount Sections.

Purpose: To develop a novel risk model incorporating Ga-PSMA PET/CT parameters for prediction of perineural invasion (PNI) of prostate cancer (PCa).

Methods: The study retrospectively enrolled 192 PCa patients with preoperative multiparametric MRI, Ga-PSMA PET/CT and radical specimen. Imaging parameters were derived from both mpMRI and PET/CT images.

Transcriptional patterns of brain structural abnormalities in CSVD-related cognitive impairment.

Background: Brain structural abnormalities have been associated with cognitive impairment in individuals with small cerebral vascular disease (CSVD). However, the molecular and cellular factors making the different brain structural regions more vulnerable to CSVD-related cognitive impairment remain largely unknown.

Materials And Methods: Voxel-based morphology (VBM) was performed on the structural magnetic resonance imaging data of 46 CSVD-related cognitive impairment and 73 healthy controls to analyze and compare the gray matter volume (GMV) between the 2 groups.

Addition of SHR-1701 to first-line capecitabine and oxaliplatin (XELOX) plus bevacizumab for unresectable metastatic colorectal cancer.

This phase 2/3 trial (NCT04856787) assessed the efficacy and safety of SHR-1701, a bifunctional protein targeting PD-L1 and TGF-β, in combination with BP102 (a bevacizumab biosimilar) and XELOX (capecitabine plus oxaliplatin) as a first-line treatment for unresectable metastatic colorectal cancer (mCRC). In this phase 2 study, a total of 62 patients with untreated, histologically confirmed colorectal adenocarcinoma and no prior systemic therapy for metastatic disease were enrolled. Patients received SHR-1701 (30 mg/kg), bevacizumab (7.

Contribution of dust emissions from farmland to particulate matter concentrations in North China Plain: Integration of WRF-Chem and WEPS model.

Wind erosion from farmland is a significant contributor to atmospheric particulate matter, particularly PM (atmospheric particulate matter with an aerodynamic diameter ≤ 10 μm), in regions with intensive agricultural activities such as the North China Plain (NCP). However, the specific impact of farmland dust emissions on regional air quality remains underexplored. This study integrated the Wind Erosion Prediction System (WEPS) model with the Weather Research and Forecasting model coupled with Chemistry (WRF-Chem) to investigate the effect of agricultural dust emissions on PM concentrations in the NCP.

Increased health risk from co-exposure to polycyclic aromatic hydrocarbons, phthalates, and per- and polyfluoroalkyl substances: Epidemiological insight from e-waste workers in Hong Kong.

The alarming surge in electronic waste (e-waste) in Hong Kong has heightened concerns regarding occupational exposure to a myriad of pollutants. Among these, polycyclic aromatic hydrocarbons (PAHs), phthalates (PAEs), and per- and polyfluoroalkyl substances (PFASs) are prevalent and known for their harmful effects, including the induction of oxidative stress and DNA damage, thereby contributing to various diseases. This study addresses gaps in knowledge by investigating exposure levels of these pollutants-measured via hydroxylated PAHs (OH-PAHs), phthalate metabolites (mPAEs), and PFASs-in urine from 101 e-waste workers and 100 office workers.

ST-YOLO: A defect detection method for photovoltaic modules based on infrared thermal imaging and machine vision technology.

Photovoltaic panels are the core components of photovoltaic power generation systems, and their quality directly affects power generation efficiency and circuit safety. To address the shortcomings of existing photovoltaic defect detection technologies, such as high labor costs, large workloads, high sensor failure rates, low reliability, high false alarm rates, high network demands, and slow detection speeds of traditional algorithms, we propose an algorithm named ST-YOLO specifically for photovoltaic module defect detection. This algorithm is based on YOLOv8s.

Identification and Correlation Analysis of Ferroptosis-Related Genes in Three Brain Regions of Patients with Schizophrenia.

Background: Schizophrenia (SZ) is a severe mental disorder that is marked by hallucinations and cognitive impairments. Ferroptosis is a type of cell death that is associated with iron and lipid peroxidation; it may play a role in SZ etiology. The present study aimed to explore the correlations between ferroptosis-related genes and SZ in three brain regions.

Architecting Multi-Level Structures and Regulating Hydrophilicity of Covalent Organic Framework Aerogels for Optimizing Mass Transport Capacity.

Architecting hierarchical structures in monolithic covalent organic frameworks (COFs) is vital for the applications of COFs in mass transport fields. The MXene-coated bilayer aerogels containing β-keto-enamine COF (MX-TpX-COF) with different chain lengths of aromatic linkers are constructed for the study. The directional freezing method endowed the COF part and MXene coating with aligned channels, and the small pores mainly exist in the former, while the larger ones in the latter.

An Efficient Biosynthetic System for Developing Functional Silk Fibroin-Based Biomaterials.

Long historical evolution and domestication endow silkworms with the super ability to synthesize and secrete massive silk proteins using silk glands. The major component of this secretion consists of silk fibroin, considered a promising biomaterial for tissue repairs and engineering. To further expand the utility of this unique protein, there is a continuing need for silk fibroin functionalization.

Intestinal mucosal barrier repair and immune regulation with an AI-developed gut-restricted PHD inhibitor.

Hypoxia-inducible factor prolyl hydroxylase (PHD) inhibitors have been approved for treating renal anemia yet have failed clinical testing for inflammatory bowel disease because of a lack of efficacy. Here we used a multimodel multimodal generative artificial intelligence platform to design an orally gut-restricted selective PHD1 and PHD2 inhibitor that exhibits favorable safety and pharmacokinetic profiles in preclinical studies. ISM012-042 restores intestinal barrier function and alleviates gut inflammation in multiple experimental colitis models.

is the pathogen of "Baotou" disease causing serious damage to cultivation in China.

In recent years, a disease called "Baotou" has been causing large-scale yield reductions of in China. Interestingly, , which once reported to be a probiotic or pathogen for multiple marine organisms, was strongly proved to be the pathogen causing "Baotou" disease in this study. Analysis of 16S rRNA gene profiling revealed that was the most abundant and dominant bacterium on the algal thalli suffering from "Baotou" disease, whereas its presence was scarcely detected on healthy thalli.