CircCENPM serves as a CeRNA to aggravate nasopharyngeal carcinoma metastasis and stemness via enhancing BMI1.

Background: Nasopharyngeal carcinoma (NPC) is a malignant head and neck cancer with high mortality and dismal prognosis. Emerging research have disclosed that circRNAs are crucial gene expression regulators engaged in tumor advancement. This work aspired to identify novel oncogenic circRNA driving NPC progression.

Superiority of Ga-DOTA-FAPI-04 PET/CT to F-FDG PET/CT in the evaluation of different cancers with bone metastases.

Background: Ga-DOTA-FAPI-04 is a new positron imaging agent, and its application in bone metastasis has been limited. The purpose of this retrospective study was to compare the diagnostic ability of Ga-DOTA-FAPI-04 PET/CT and F-FDG PET/CT to detect bone metastases in patients with different types of cancer.

Methods: A total of 293 patients with pathologically confirmed primary malignancies were examined with Ga-DOTA-FAPI-04 PET/CT and F-FDG PET/CT within one week.

Polymer-based O-band waveguide amplifier using NaLuF: Yb, Pr-PMMA nanocomposite as the gain medium.

Nanoparticle (NP)-doped polymer waveguide devices have attracted increasing interest in some rapidly developing areas of broadband communications because they are easy to integrate on chip. As an important part of the gain medium of waveguide amplifiers, lanthanide-doped nanoparticles have been widely studied to improve the amplification performance of devices. However, current research work is almost limited to erbium-doped nanoparticles and amplifiers operating in the C-band.

Systematic Identification of Mitochondrial Signatures in Alzheimer's Disease and Inflammatory Bowel Disease.

Mitochondrial dysfunction is increasingly recognized as a shared feature of Alzheimer's disease (AD) and inflammatory bowel disease (IBD), linked through overlapping pathways of hypoxia and immune dysregulation. Our study integrated transcriptomic and genetic analyses to uncover mitochondria-related mechanisms underlying these diseases. By analyzing multiple AD and IBD datasets through differential expression gene (DEG) analyses, biological pathway enrichment, and co-expression module construction, we identified hypoxia-induced mitochondrial dysfunction as a central risk factor for both conditions.

Efficient Extraction, Chemical Characterization, and Bioactivity of Essential Oil From Pine Needles.

Introduction: Pine needles are a rich source of bioactive compounds, and there are few reports on the extraction and identification of active substances in various types of pine needles.

Objectives: The objective of this study is to enhance the efficiency and yield of pine needle essential oil extraction by employing an innovative ultrasonic-assisted salt-out hydrodistillation technology. It also aims to establish a correlation between gas chromatography-mass spectrometry (GC-MS) and electronic nose (E-nose) to distinguish essential oils from Cedrus deodara, Pinus thunbergii, Pinus massoniana, and Pinus koraiensis.

Thyroid hormone replacement therapy in dialysis/renal insufficiency patients.

Dialysis/renal insufficiency patients are often accompanied by hypothyroidism due to renal damage, the mechanisms of which are complex. The use of thyroid hormone replacement therapy in such patients has become an important clinical issue. This article reviews the mechanism of hypothyroidism in dialysis/renal insufficiency patients and describes the importance and precautions of thyroid hormone replacement therapy to provide a reference for clinical diagnosis and treatment.

Study on Damage Mechanism of Fiber Concrete with Initial Pores.

Currently, fiber-reinforced concrete, as a building material, is widely used in highway bridges and tunnel linings, and it has become a global research hotspot, with indoor tests, numerical simulations, performance studies, and application scenarios surrounding it. Many researchers have conducted experiments and analyses on the damage patterns of fiber-reinforced concrete under different conditions. However, there is relatively little research on the mechanical properties of fiber-reinforced concrete that already contains initial damage.

A Biomimetic Sweeping Microrobot for Active Therapy of Ulcerative Colitis.

Overproduction of pathogenic cell-free DNA (cfDNA) and reactive oxygen species (ROS) plays crucial roles in the onset and perpetuation of ulcerative colitis (UC). Inspired by sweeping robots, a magnesium@polylactic acid-glycolic acid copolymer@polyethylenimine (Mg@PLGA@PEI) microswimmer capable of cleaning off deleterious disease triggers along its path of progress is designed. Mg@PLGA@PEI is successfully synthesized by adopting a core-shell structure with a small opening which allows for Mg-water reaction.

Pressure-Driven Circularly Polarized Luminescence Enhancement and Chirality Amplification.

Achieving ultrahigh-color-purity circularly polarized luminescence (CPL) in low-dimensional chiral perovskites is challenging due to strong electron-phonon coupling caused by lead halide octahedral distortion. Herein, the circularly polarized piezoluminescence behaviors of six novel chiral perovskites, (/-3-XPEA)PbBr (PEA = phenethylamine; X = F, Cl, Br), were systematically investigated. Upon compression, (/-3-ClPEA)PbBr exhibits significant piezofluorochromic behaviors, transforming from yellow CPL to ultrahigh-color-purity deep-blue CPL.

SEW2871 attenuates myocyte necroptosis in heart failure through inhibition of oxidative stress and inflammatory cytokines.

Background And Purpose: Sphingosine-1-phosphate (S1P)/S1P receptor signalling exerts cardioprotective effects. However, the effect of the selective S1P receptor agonist SEW2871 on myocyte necroptosis in heart failure and the underlying mechanisms are unknown. In the present study, we tested the hypothesis that SEW2871 attenuates myocyte necroptosis in heart failure through inhibition of oxidative stress and inflammatory cytokines.

Macrophage polarization-related gene SOAT1 is involved in inflammatory response and functional recovery after spinal cord injury.

Macrophages polarization play crucial roles in regulating inflammation and functional recovery after spinal cord injury (SCI). This study aimed to investigate the key macrophage polarization-related genes (MPRGs) for the treatment of SCI. Our research involved identifying differentially expressed genes (DEGs), using immune infiltration analysis, weighted gene co-expression network analysis (WGCNA) and machine learning to screening out key MPRGs in the GSE5296.

Nanospecific effect rather than dissolved Cu dominates the impact of CuO nanoparticles on soil microbiota.

CuO nanoparticles (NPs) have raised significant concerns due to their extensive application in agriculture and potential ecological impacts in recent decades. Identification of the action mechanisms for soil microbiota response in a long exposure time with respect to the chemical speciation of CuO NPs remained scarce. A 63-day laboratory soil microcosms experiment was conducted to evaluate the impact of CuO NPs along with its dissolved Cu on soil microbiota.

Assessment of greenhouse gas emissions from coal-fired power plants based on non-dispersive infrared technique: a case study.

Greenhouse gases (GHGs) such as carbon dioxide (CO), methane (CH), and nitrous oxide (NO) emanating from coal-fired power plants contribute substantially to the greenhouse effect. In the face of the continual trend of global warming, curbing GHGs emissions has emerged as an essential step to lessen anthropogenic carbon emissions and attain the targets of carbon peak and neutrality. The practical implementation of strategies to reduce carbon emissions from coal-fired power stations necessitates the precise monitoring and recording of associated greenhouse gas emissions.

MXene-MWCNT Conductive Network for Long-Lasting Wearable Strain Sensors with Gesture Recognition Capabilities.

In this work, a conductive composite film composed of multi-walled carbon nanotubes (MWCNTs) and multi-layer TiCTx MXene nanosheets is used to construct a strain sensor on sandpaper Ecoflex substrate. The composite material forms a sophisticated conductive network with exceptional electrical conductivity, resulting in sensors with broad detection ranges and high sensitivities. The findings indicate that the strain sensing range of the Ecoflex/TiCTx/MWCNT strain sensor, when the mass ratio is set to 5:2, extends to 240%, with a gauge factor (GF) of 933 within the strain interval from 180% to 240%.

ZNF32 histidine 179 and 183 single-site and double-site mutations promote nuclear speckle formation but differentially regulate the proliferation of breast cancer cells.

Studies have shown that histidine 179A and 183A (HA) of the ZNF32 protein exhibit point-like nuclear speckles, but the causes of such speckle formation and their effects on breast cancer cells remain unknown. In this study, we prepared breast cancer cells containing ZNF32 HA, HA, and HA and observed nuclear speckles in all three cell types. Transcriptome analysis showed that these nuclear speckles may be related to changes in the activities of the cell growth factor and RNA polymerase II transcription factor.

Hemozoin: a waste product after heme detoxification?

Background: Hemozoin is considered a waste byproduct of heme detoxification following hemoglobin digestion; consequently, the biological functions of hemozoin in hemozoin-producing organisms have often been overlooked. However, recent findings indicate that Schistosoma hemozoin facilitates the transfer of iron from erythrocytes to eggs through its formation and degradation, thereby increasing interest in the role of malarial hemozoin.

Methods: Using transmission electron microscopy, we compared the formation of Schistosoma hemozoin and malaria hemozoin.

Use quercetin for pulmonary fibrosis: a preclinical systematic review and meta-analysis.

Background: Pulmonary fibrosis (PF) is an age-related interstitial lung disease, which lacks effective drug treatment at present. Quercetin has been shown to have favorable anti-inflammatory and anti-fibrotic properties, and preliminary evidence suggests its potential efficacy and tolerability in PF patients. However, a comprehensive systematic review and evaluation of the protective effects and potential mechanisms of quercetin in PF models remains to be completed.

Enhancing Robustness and Charge Transfer Kinetics of Sodium-Ion Batteries through Introduction of Anionic Anchoring Separators.

Ionic transport critically dictates the performance of the batteries. Here, we proposed an anion anchoring strategy for enhancing Na transport kinetics that was based on introducing a separator with a positive surface potential. Besides, we developed a nuclear magnetic resonance-assisted Hittorf approach to address the limitation of the traditional Bruce-Vincent approach itself in order to accurately quantify the migration dynamics of anions on the time scale.

Effects of peroxidized lipids on intestinal morphology, antioxidant capacity and gut microbiome in piglets.

This study investigated the effect of peroxidized lipids on piglets' growth performance, intestinal morphology, inflammatory reactions, oxidative stress in the liver, duodenum, jejunum, ileum, and colon, and ileal microbiota. Twenty piglets (Duroc × [Landrace × Yorkshire]; age = 21 d old, BW = 6.5 ± 1 kg) were randomly assigned to two groups with 10 replicates per group and one piglet per replicate.

Covalent Anchoring of Mechanical Polymer for Highly Stable Zinc Metal Batteries.

Artificial interfacial protective coatings (IPCs) on Zn anodes provide a viable solution for suppressing dendritic growth by spatially confining and homogenizing the Zn flux. However, repeated Zn deformation during electroplating/stripping cycles can lead to the rupture or exfoliation of IPCs, as well as the formation of detrimental interfacial gaps. Herein, a highly durable IPC is developed on a Zn substrate using a mechanically robust fluorinated polyimide nanofilm (FPI).

Dissecting biological heterogeneity in major depressive disorder based on neuroimaging subtypes with multi-omics data.

The heterogeneity of Major Depressive Disorder (MDD) has been increasingly recognized, challenging traditional symptom-based diagnostics and the development of mechanism-targeted therapies. This study aims to identify neuroimaging-based MDD subtypes and dissect their predominant biological characteristics using multi-omics data. A total of 807 participants were included in this study, comprising 327 individuals with MDD and 480 healthy controls (HC).

Heterogeneous Graph Representation Learning Framework for Resting-State Functional Connectivity Analysis.

Brain functional connectivity analysis is important for understanding brain development and brain disorders. Recent studies have suggested that the variations of functional connectivity among multiple subnetworks are closely related to the development of diseases. However, the existing works failed to sufficiently capture the complex correlation patterns among the subnetworks and ignored the learning of heterogeneous structural information across the subnetworks.

Manifoldron: Direct Space Partition via Manifold Discovery.

A neural network (NN) with the widely-used ReLU activation has been shown to partition the sample space into many convex polytopes for prediction. However, the parametric way a NN and other machine learning models use to partition the space has imperfections, e.g.