Publications by authors named "Wang Fang-Jie"
Purpose: Vibrio vulnificus (V. Vulnificus) infection is characterized by rapid onset, aggressive progression, and challenging treatment. Bacterial resistance poses a significant challenge for clinical anti-infection treatment and is thus the subject of research.
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- Gastric cancer (GC) has a high mortality rate, making it essential to understand its mechanisms and identify new treatment targets, particularly focusing on long non-coding RNAs (lncRNAs) and their role in cancer prognosis.
- This study explores the expression and function of ferroptosis-related lncRNAs (FRlncRNAs) in GC using RNA sequencing and clinical data, identifying 33 survival-related FRlncRNAs, including the highly expressed LASTR lncRNA associated with poor patient outcomes.
- The research shows that high LASTR levels correlate with shorter survival rates in GC patients, and reducing LASTR expression significantly decreases GC cell proliferation, suggesting that LASTR could serve as an independent prognostic factor and therapeutic target
The multi-generation heredity trait of hypertension in human has been reported, but the molecular mechanisms underlying multi-generational inheritance of hypertension remain obscure. Recent evidence shows that prenatal inflammatory exposure (PIE) results in increased incidence of cardiovascular diseases, including hypertension. In this study we investigated whether and how PIE contributed to multi-generational inheritance of hypertension in rats.
View Article and Find Full Text PDF[Study on anti-osteoporosis effect of Eucommiae Cortex based on GC-MS metabonomics].
Zhongguo Zhong Yao Za Zhi
November 2020
Based on GC-MS metabolomics and biochemical index analysis, the mechanism of bone mass loss in osteoporosis and the evaluation of anti-osteoporosis in Eucommiae Cortex were studied. The OVX rats model was established by bilateral ovariectomized. The routine indexes such as BMC, BMD, BGP and TRAP5 b were determined.
View Article and Find Full Text PDF[Effect of nesprin-1 in the differentiation of mouse embryonic stem cells into cardiomyocytes].
Sichuan Da Xue Xue Bao Yi Xue Ban
March 2012
Objective: To investigate the role of nesprin-1 in mouse embryonic stem cells differentiation into cardiomyocyte.
Methods: Hanging drop-suspension-adherence method was applied for the differentiation of mouse embryonic stem cells into cardiomyocytes under the inducing of salvia miltorrhiza and 5-azacytidine. Changes in nesprin-1 gene expression were detected by using Western blotting and immunofluorescent assay.