The Treatment with Xinfeng Capsule Can Reduce the Risk of Readmission for Patients with Rheumatoid arthritis:A Cohort Study of Approximately 10000 Individuals.

Objective: The present study aimed to investigate the potential association between the treatment with Xinfeng Capsule (XFC) and the risk of readmission among patients with rheumatoid arthritis (RA).

Methods: Through a retrospective approach, data were collected from all hospitalized patients diagnosed with RA at the First Affiliated Hospital of Anhui University of Chinese Medicine between 2013 and 2021. To mitigate selection bias and confounding factors, patients were stratified into an XFC group and a Non-XFC (Non-XFC) group based on their treatment status using propensity score matching with a 1:2 ratio.

Enhancing Thermal Management of Graphene Devices by Self-Assembled Monolayers.

Two-dimensional graphene has emerged as a promising competitor to silicon in the post-Moore era due to its superior electrical, optical, and thermal properties. However, graphene undergoes a strong degradation in its in-plane thermal conductivity when it is coupled to an amorphous substrate. Meanwhile, the weak van der Waals interaction between graphene and the dielectric substrate leads to high interfacial thermal resistance.

Improved Thermal Dissipation in a MoS Field-Effect Transistor by Hybrid High- Dielectric Layers.

Transition metal dichalcogenides like MoS have been considered as crucial channel materials beyond silicon to continuously advance transistor scaling down owing to their two-dimensional structure and exceptional electrical properties. However, the undesirable interface morphology and vibrational phonon frequency mismatch between MoS and the dielectric layer induce low thermal boundary conductance, resulting in overheating issues and impeding electrical performance improvement in the MoS field-effect transistors. Here, we employed hybrid high- dielectric layers of AlO/HfO to simultaneously reduce the interfacial thermal resistance and improve device electrical performance.

Effect of paternal age on clinical outcomes of fertilization-embryo transfer cycles.

Purpose: This study aimed to investigate the impact of paternal age > 40 years on clinical pregnancy and perinatal outcomes among patients undergoing fertilization treatment.

Methods: We selected 75 male patients (aged > 40 years) based on predefined inclusion and exclusion criteria. Propensity score matching was performed in a 1:3 ratio, resulting in a control group (aged ≤ 40 years) of 225 individuals.

Migration and accumulation of microplastics in soil-plant systems mediated by symbiotic microorganisms and their ecological effects.

The coexistence of microorganisms in complex soil environments greatly affects the environmental behavior and ecological effects of microplastics (MPs). However, relevant studies are sparse, and internal mechanisms remain unclear. Herein, arbuscular mycorrhizal fungi (AMF), a common symbiotic microorganism in the soil-plant system, was proved to significantly affect MPs absorption and migration with a "size effect".

A new isoprenyl-phenol-type meroterpenoid from mangrove endophytic fungus sp. GXNU-Y65.

Asperphenol A (), a new isoprenyl-phenol-type meroterpenoid, was isolated from the mangrove endophytic fungus sp. GXNU-Y65 together with five known compounds (-. All structures were assigned using extensive NMR spectroscopic data and electronic circular dichroism (ECD) calculations.

New Meroterpenoids and α-Pyrone Derivatives Isolated from the Mangrove Endophytic Fungal Strain sp. GXNU-Y85.

Two new meroterpenoids, aspergienynes O and P ( and ), one new natural compound, aspergienyne Q (), and a new α-pyrone derivative named 3-(4-methoxy-2-oxo-2H-pyran-6-yl)butanoic acid () were isolated from the mangrove endophytic fungal strain sp. GXNU-Y85, along with five known compounds (-). The absolute configurations of those new isolates were confirmed through extensive analysis using spectroscopic data (HRESIMS, NMR, and ECD).

Alkaloids from and their anti-proliferative activity against A549 cells by regulating the EGFR/AKT/mTOR pathway.

is frequently used as a traditional Chinese medicine and food supplement. Our previous study revealed that its constituent compounds were able to inhibit cancer cell proliferation. In our continuous exploration of bioactive compounds in , we isolated ten alkaloids (-), including one new natural compound (), and nine known alkaloids (), from an ethanolic extract of the whole plant.

Lateral Heterostructure Formed by Highly Thermally Conductive Fluorinated Graphene for Efficient Device Thermal Management.

The continued miniaturization of chips demands highly thermally conductive materials and effective thermal management strategies. Particularly, the high-field transport of the devices built with 2D materials is limited by self-heating. Here a systematic control of heat flow in single-side fluorinated graphene (FG) with varying degrees of fluorination is reported, revealing a superior room-temperature thermal conductivity as high as 128 W m K.

Antipathogenic Activities of Volatile Organic Compounds Produced by LT1 against LC1, the Pathogen of Southern Blight in .

This study explores the antipathogenic properties of volatile organic compounds (VOCs) produced by LT1, isolated from the rhizosphere soil of . The impact of these VOCs on the mycelial growth of LC1, the causative agent of southern blight in , was evaluated using a double Petri-dish assay. The biocontrol efficacy of these VOCs was further assessed through leaf inoculation and pot experiments.

Monocyte HLA-DR level on admission predicting in-hospital mortality rate in exertional heatstroke: A 12-year retrospective study.

Background: Exertional heatstroke (EHS), a fatal illness, pronounces multiple organ dysfunction syndrome (MODS) and high mortality rate. Currently, no ideal factor prognoses EHS. Decreased monocyte human leukocyte-DR antigen (mHLA-DR) has been observed in critically ill individuals, particularly in those with sepsis.

LT1: a potential biocontrol agent for southern blight on .

Introduction: Southern blight, caused by , poses a serious threat to the cultivation of , a plant with significant medicinal value. The overreliance on fungicides for controlling this pathogen has led to environmental concerns and resistance issues. There is an urgent need for alternative, sustainable disease management strategies.

Diisoprenyl Cyclohexene-Type Meroterpenoids with Cytotoxic Activity from a Mangrove Endophytic Fungus sp. GXNU-Y85.

Five new diisoprenyl cyclohexene-type meroterpenoids, aspergienynes J-N (-), along with three known analogues (-), were obtained from the mangrove endophytic fungal strain sp. GXNU-Y85. The chemical structures, including their absolute configurations, were established via spectroscopic data and comparison of experimental and calculated ECD spectra.

The effect of long-term traditional Chinese medicine treatment on extra-articular lesions of rheumatoid arthritis patients based on propensity score matching: A retrospective cohort study.

Objective: To explore the efficacy of long-term traditional Chinese medicine (TCM) treatment on the occurrence of extra-articular lesions in rheumatoid arthritis (RA) patients.

Methods: Our retrospective cohort study included patients diagnosed with RA between January 2018 to December 2019. Patients were divided into TCM treatment group and control group according to whether they received TCM treatment for more than three months.

Xinfeng capsule inhibits lncRNA NONHSAT227927.1/TRAF2 to alleviate NF-κB-p65-induced immuno-inflammation in ankylosing spondylitis.

Ethnopharmacological Relevance: Ankylosing spondylitis (AS) is a chronic rheumatic disease known for its insidious and refractory symptoms, primarily associated with immuno-inflammation in its early stages, that affects the self-perception of patients (SPP). The exploration of long noncoding RNA (lncRNA) in immuno-inflammation of AS has garnered considerable interest. Additionally, the effectiveness of traditional Chinese medicine Xinfeng Capsule (XFC) in mitigating immuno-inflammation in AS has also been observed.

Hypercoagulability in Rheumatoid Arthritis: A Bibliometric Analysis and Retrospective Data Mining Study.

Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic inflammation, leading to joint deformities and functional loss. RA progression is accompanied by abnormalities in the coagulation-fibrinolysis system, clinically manifested as a hypercoagulable state. However, there are currently no bibliometrics or visualization analysis in this field.

De Novo RNA Sequencing and Transcriptome Analysis of Gene Expression during Sclerotium Development.

is a destructive soil-borne fungal pathogen that causes stem rot in cultivated plants. However, little is known about the genetic basis of sclerotium development. In this study, we conducted de novo sequencing of genes from three different stages of (mycelia, early sclerotium formation, and late sclerotium formation) using Illumina HiSeq 4000.

Diisoprenyl-cyclohexene-type meroterpenoids from a mangrove endophytic fungus Aspergillus sp. GXNU-Y65 and their anti-nonalcoholic steatohepatitis activity in AML12 cells.

Nine previously undescribed diisoprenyl-cyclohexene-type meroterpenoids, aspergienynes A-I, together with five known analogues, were obtained from the mangrove endophytic fungal strain Aspergillus sp. GXNU-Y65. The diisoprenyl-cyclohexene-type meroterpenoids were elucidated based on multispectroscopic analysis, and the previously undescribed compounds' absolute configurations were established via electronic circular dichroism calculations.

A nomogram based on lymphocyte percentage for predicting hospital mortality in exertional heatstroke patients: a 13-year retrospective study.

Background: Exertional heatstroke (EHS) is a life-threatening disease without ideal prognostic markers for predicting hospital mortality.

Methods: This is a single-center retrospective study. Clinical data from EHS patients admitted to the Intensive Care Unit (ICU) of the General Hospital of Southern Theatre Command between January 1, 2008, and December 31, 2020, were recorded and analyzed.