Publications by authors named "Wang Dan-dan"
Vulnerable atherosclerotic plaque is a type of plaque that poses a significant risk of high mortality in patients with cardiovascular disease. Ultrasound has long been used for carotid atherosclerosis screening and plaque assessment due to its safety, low cost and non-invasive nature. However, conventional ultrasound techniques have limitations such as subjectivity, operator dependence, and low inter-observer agreement, leading to inconsistent and possibly inaccurate diagnoses.
View Article and Find Full Text PDFRemote ischemic preconditioning (RIPC) induces the expression of unidentified protective cytokines that mitigate lung ischemia-reperfusion injury (LIRI). This study hypothesizes that MOTS-c, a mitokine with potent protective effects against mitochondrial damage, contributes to RIPC-mediated protection by alleviating endothelial barrier dysfunction. In human lung transplantation patients, serum levels of MOTS-c significantly decreased following IR injury but were markedly increased when RIPC was performed prior to transplantation.
View Article and Find Full Text PDFAs the application of the Global Navigation Satellite System (GNSS) continues to expand, its stability and safety issues are receiving more and more attention, especially the interference problem. Interference reduces the signal reception quality of ground terminals and may even lead to the paralysis of GNSS function in severe cases. In recent years, Low Earth Orbit (LEO) satellites have been highly emphasized for their unique advantages in GNSS interference detection, and related commercial and academic activities have increased rapidly.
View Article and Find Full Text PDFFor millennia, humans have harnessed thermal energy to treat cancer. However, delivering energy to tumor tissues in traditional hyperthermia remains a significant challenge. Nanotechnology has revolutionized this approach, enabling nanomaterials to target tumors precisely and act as internal heat sources.
View Article and Find Full Text PDFHeme, abundant in the mitochondria of cancer cells, is a key target for the anticancer activity of artemisinin (ART). Current strategies to enhance the anticancer activity of ART focus solely on its delivery to heme-enriched subcellular localizations while overlooking the decisive effects of ART-heme interactions. Here, we propose an ingenious strategy that synergizes mitochondria-targeted drug delivery and linker-mediated drug conformation modulation, thereby significantly enhancing the anticancer activity of ART.
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- The study discusses a rare case where an intracranial epidermoid cyst transformed into malignant squamous cell carcinoma (SCC) in a 47-year-old woman, leading to severe neurological symptoms like double vision and memory loss.
- Whole exome sequencing was performed on the patient, revealing two significant genetic mutations in the GJB2 and TLR2 genes that may contribute to the development of the SCC.
- The findings highlight the potential importance of these genes in understanding and treating SCC and support whole exome sequencing as a valuable tool for identifying genetic factors in complex diseases.
Article Synopsis
- The study investigated how well the body absorbs different forms of eicosapentaenoic acid (EPA) through lymphatic pathways, comparing gastric and intestinal hydrolysates of EPA-enriched phosphoethanolamine plasmalogen (EPA-pPE).
- Findings showed that EPA peaks in gastric and intestinal hydrolysates occurred earlier and at higher concentrations compared to EPA-pPE, indicating that pre-hydrolysis enhances lymphatic absorption.
- Additionally, different forms of EPA from hydrolysates influenced the production of various lipid compounds in the lymph fluid, providing valuable insights into how dietary structures affect EPA metabolism.
Article Synopsis
- The study explored how the herbal formula Qing-Luo-Yin (QLY) affects SIRT1, a protein that regulates metabolism and immune responses, in a rat model of arthritis.
- Treatment with QLY showed a significant reduction in fat in the liver and white adipose tissues of the rats, along with improved joint conditions and altered expression of certain SIRT1-related proteins.
- The research concluded that inhibiting SIRT1 in adipose tissue helps reduce visfatin production in arthritis, which in turn may lessen inflammation, marking a possible anti-rheumatic mechanism of QLY that operates independently of immune regulation.
Article Synopsis
- SGLT2 inhibitors (SGLT2i) show promise as a treatment for non-alcoholic fatty liver disease (NAFLD) by improving metabolic indexes and reducing liver fat and fibrosis in mouse models.
- The study found that SGLT2i treatment decreased inflammation and promoted a shift in macrophage types from M1 (pro-inflammatory) to M2 (anti-inflammatory) in liver tissues.
- Researchers identified PFKFB3, an enzyme involved in glycolysis, as a key target for SGLT2i action, indicating a new therapeutic approach for treating NAFLD by inhibiting lipogenesis in liver cells through macrophage interaction.
Androgen receptor expression and clinical characteristics in breast cancer.
World J Surg Oncol
September 2024
Article Synopsis
- The study aimed to explore how androgen receptor (AR) expression in breast cancer correlates with various clinical characteristics of patients.
- A review of records from 432 patients showed that 87.27% expressed AR, with significant links found between AR expression and factors like histological grade and tumor recurrence, but not with age or menopausal status.
- The findings suggest that AR expression could be a valuable biomarker for identifying molecular types and predicting poor prognosis in breast cancer, highlighting its potential as a therapeutic target.
Article Synopsis
- Benzo (k) fluoranthene (BkF) negatively impacts male reproduction, but its exact mechanism is not yet fully understood, prompting this study on the RNA-reading protein YTHDF2's role in this process.
- Exposure to BkF increased cell apoptosis in mouse spermatocytes and led to decreased levels of the anti-apoptotic protein BCL2, while also raising levels of pro-apoptotic proteins P53 and BAX.
- The research revealed that YTHDF2 promotes the degradation of BCL2, exacerbating damage from BkF, as overexpression of YTHDF2 reduced cell viability and heightened apoptosis, whereas knocking it down had the opposite effects.
Article Synopsis
- Head and neck squamous cell carcinoma (HNSCC) has a high recurrence rate and low survival, leading to poor patient quality of life, but SM-1, derived from PAC-1, could be effective in enhancing treatment outcomes.
- This study analyzed the effects of SM-1 on HNSCC cell lines using various methods, discovering that it not only inhibited cell growth but also worked better than other treatments when combined with radiation.
- Results indicated that SM-1 causes G2/M phase cell cycle arrest and apoptosis by activating caspase-3, suggesting its potential as a radiosensitizer for HNSCC in future clinical trials.
Article Synopsis
- - Reprogramming tumor-associated macrophages (TAMs) to an inflammatory state can boost the effectiveness of immune checkpoint blockade (ICB) therapy, but how to achieve this using mitochondrial transplantation has not been explored until now.
- - The study introduces a method to shift M2 TAMs to M1 TAMs by transplanting mannosylated mitochondria from M1 macrophages, encouraging a metabolic change from oxidative phosphorylation to glycolysis, which enhances their inflammatory response.
- - This mitochondrial transplantation not only improves anti-tumor responses by increasing activation of T cells but also offers a promising new approach for enhancing cancer immunotherapy and expanding the use of mitochondrial tech in clinical settings.
Article Synopsis
- The study investigates the expression patterns and prognostic significance of PLOD family genes in breast cancer, revealing that PLOD1 and PLOD3 are upregulated in cancerous tissues.
- High levels of these genes are linked to worse survival rates and are particularly elevated in younger patients and those with aggressive forms like triple negative breast cancer (TNBC).
- Findings suggest that PLOD family genes could serve as potential prognostic biomarkers and that targeting PLOD inhibitors may offer a new treatment approach for breast cancer.
Article Synopsis
- Root hairs (RHs) in vascular plants develop in response to internal and external factors like ethylene and light, but the interaction between these signals in RH development is not fully understood.
- Research shows that the protein COP1 plays a crucial role in coordinating ethylene and light signals, mainly by suppressing RH development in dark conditions.
- COP1 promotes the degradation of specific proteins (ACS2 and ACS6) that regulate ethylene levels, suggesting that it has a dual role: inhibiting RH growth while supporting hypocotyl elongation under certain conditions, enhancing overall seedling survival.
Article Synopsis
- Hyperproliferation of vascular smooth muscle cells (VSMCs) contributes to changes in blood vessel structure in hypertension, and this study explores the role of BACH1 and microRNAs in this process.
- Researchers found that miR-196a-5p negatively influences VSMC growth by targeting BACH1, with experiments showing that increasing miR-196a-5p reduces VSMC proliferation and oxidative stress.
- The study suggests that lowering BACH1 through miR-196a-5p could be an effective approach to slowing down the harmful effects of VSMC growth in hypertensive conditions.
Article Synopsis
- Pulmonary hypertension is a serious concern for patients on maintenance hemodialysis, affecting their quality of life and overall safety.
- A study investigated the impact of pedal-powered bicycle exercises alongside conventional treatments on patients with pulmonary arterial hypertension undergoing hemodialysis.
- Results showed that the intervention group experienced significant improvements in muscle strength, mental health scores, and various pulmonary function metrics, suggesting that combining aerobic exercise with standard medical treatment can enhance patient outcomes.
Article Synopsis
- The study investigates how effective a combination of thoracic paravertebral block (TPVB) and sufentanil-based multimodal analgesia is in managing pain and preserving cognitive function in patients undergoing thoracoscopic surgery for lung cancer.
- Researchers analyzed data from 107 patients to compare postoperative pain scores and cognitive function using tests like the Ramsay Sedation Scale and Mini-Mental State Examination at various time intervals post-surgery.
- Results showed no significant differences in sedation or pain scores between the two groups, indicating that the combination treatment didn't provide added benefits for postoperative pain management or cognitive preservation.
Article Synopsis
- Carboxylesterase 1 (CES1) is an enzyme that plays a key role in metabolizing various substances in mammals, and its inhibition could help in treating metabolic disorders like obesity and fatty liver disease.
- The study aimed to identify effective inhibitors of CES1 from synthetic pyrazolones, finding that compounds 25, 26, and 27 showed varying types of inhibition against CES1 in lab tests.
- These compounds also demonstrated the ability to prevent fat accumulation in mouse adipose cells, suggesting their potential for developing treatments for hyperlipidemia and related conditions.
Article Synopsis
- * Researchers isolated 69 soil microorganisms and discovered that a specific strain, Burkholderia pyrrocinia (F12), effectively reduces the pathogen’s activity, achieving a 95.8% reduction in lab tests and 63.09% in the field.
- * B. pyrrocinia F12 also inhibited the production of the mycotoxin deoxynivalenol (DON), suggesting its potential as a biocontrol agent and biofertilizer for sustainable agriculture.
Article Synopsis
- This study examines the biogeography and community assembly of soil microorganisms in var. forests across northern China using high-throughput sequencing and null model analysis.
- It finds that rare fungal taxa are more influenced by environmental factors and regional changes compared to abundant taxa, which are dominated by Agaricomycetes and Leotiomycetes.
- The research reveals that while all taxa are primarily governed by stochastic processes, rare taxa show a stronger influence from deterministic processes, with precipitation and temperature being key factors in this balance.
Article Synopsis
- This study investigates the role of white adipose tissue (WAT) in rheumatoid arthritis (RA), suggesting it could be a potential target for treatment.
- Researchers compared the WAT of healthy rats to those with adjuvant-induced arthritis (AIA) and found that AIA rats had smaller WAT but higher secretion levels of inflammatory proteins.
- The study concludes that specific hepatokines enhance inflammatory responses in pre-adipocytes, which may worsen RA, indicating that targeting this dysfunction could help reduce the severity of the disease.
Article Synopsis
- * The study analyzed data from 3,785 participants aged 40 and older, focusing on retinal measurements and cognitive function, using logistic regression methods.
- * Findings revealed that those with CI had significantly thinner retinal nerve fiber layer (RNFL) measurements, particularly in participants without major arterial blockages, suggesting that retinal changes may indicate underlying cognitive issues.
Article Synopsis
- Gut microbiota convert various alkaloids and TMAO into TMA, which is linked to cardiovascular and metabolic diseases, but the specific role of TMA in health impacts of TMAO remains unclear.
- In a study with male C57BL/6J mice, oral TMAO treatment for 8 weeks significantly increased glucose and lipid levels, as indicated by higher OGTT curves and elevated triglyceride and cholesterol levels, compared to control groups.
- The findings suggest that TMAO negatively affects glucose and lipid metabolism in mice potentially through its conversion to TMA by gut microbiota, highlighting the need for further research on this pathway.