Integrated multi-omics to elucidate the interplay between rumen microorganisms and host metabolism in Hu sheep supplemented with herbal preparations.

Unlabelled: The aim of this experiment was to study the effects of herbal preparations on serum metabolites, rumen microorganisms, and their metabolites, and the relationship between them. Hu sheep ram lambs with an average initial weight of (19.57 ± 1.

Compression-Durable Soft Electronic Circuits Enabled by Embedding Self-Healing Biphasic Liquid-Solid Metal Into Microstructured Elastomeric Channels.

Compression strongly degrades the electrical conductivity of the liquid-metal-based circuits because the liquid state is prone to be squashed. Here, a new compressible and stretchable biphasic liquid-solid self-healing circuit is proposed by filling GalnSn-BilnSn biphasic metal into micropillar-embedded channels. The underlying BilnSn solid alloy layer serves as a compression resistance layer, while the upper GalnSn liquid metal layer enables the real-time filling of the cracks in the solid layer under large deformations, resulting in autonomous self-healing and maintenance of conductivity under both stretching and compression.

Spatial confinement-regulated peroxymonosulfate activation by bimetallic-doped hollow carbon spheres for rapid removal of organic pollutants.

Non-radical advanced oxidation processes (AOPs) have gained significant attention as a highly promising approach for eliminating persistent pollutants from water. These methods demonstrate superior effectiveness in mitigating the interference of coexisting anions compared to traditional radical-based methods. In this study, a singlet oxygen (O)-dominated process is developed for the degradation of metronidazole (MNZ), employing bimetallic-doped hollow carbon spheres (CoCu-HCS) as catalysts and peroxymonosulfate (PMS) as the oxidant.

Increased Prevalence of Stroke After Heart Transplant in the New Allocation System Era.

Background: Temporary mechanical circulatory support (tMCS) usage has increased after the 2018 United Network for Organ Sharing (UNOS) heart transplant allocation criteria change. However, tMCS is associated with increased stroke risk and may impact stroke rates after heart transplant. This study sought to determine the impact of the criteria change on post-transplant stroke rates.

Two Antiferromagnetic Tetradecanuclear Iron Oxo Clusters Derived from a Pentadecanuclear Cluster via Substitutions of Shell Iron Polyhedra with Non-Metallic Oxoanions.

Substituting certain atoms in a metal-oxo cluster (MOC) can enrich its structure, properties, and applications, often involving the replacement of one metal polyhedron with another that exhibits a comparable coordination environment. Herein, we synthesized three clusters , , and , with the crystal compositions of [Fe(SO)O(tea)Cl](FeClOFeCl)·4(CHN)·18(HO) (tea = deprotonated triethanolamine), [Fe(SeO)O(tea)Cl](FeClOFeCl)·(CHN)·20(HO), and [FeO(tea)Cl](FeCl)·Cl·22(HO), using similar solvothermal methods. All three clusters exhibit similar cage-like structures, with (X = S or Se) differing by substituting a shell iron polyhedron with a nonmetallic XO tetrahedron.

Compact and efficient grating coupler design combining a metalens and a topology-optimized mode converter.

Efficient and compact grating coupler designs are crucial for enhancing the performance of photonic integrated chips. In this work, we propose a design approach that combines metalens technology and topology optimization. As a proof of concept, we first designed an on-chip metalens to preliminarily improve the transmission efficiency of a compact mode converter.

Effect of perioperative esketamine use on emergency delirium in children undergoing tonsillectomy and adenoidectomy: a systematic review and meta-analysis of randomized controlled trials.

Background: Emergence delirium(ED) is a common postoperative complication in children undergoing tonsillectomy and adenoidectomy under general anesthesia. There is no high-quality evidence on the relationship between esketamine and ED. The systematic review and meta-analysis was performed to investigate the effect of perioperative esketamine use on ED in children undergoing tonsillectomy and adenoidectomy.

Generation of a transgene-free Induced pluripotent stem (iPS) cell line (JNCHi002-A) from a female heterozygous carrier of the low density lipoprotein receptor (LDLR) gene mutation (c.387delC).

The low density lipoprotein receptor （LDLR) gene (OMIM#606945)encodes a protein of 860 amino acids. The encoded protein typically anchors itself to the cell membrane, where it facilitates the binding and internalization of low-density lipoprotein/cholesterol into the cell. Once inside, lysosomes liberate the cholesterol, which then becomes available to suppress the activity of the microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.

Continuous Glucose Monitoring in Hospitalized Adults With Diabetic Ketoacidosis: A Prospective Open-Label Pilot Study.

Background: Continuous glucose monitoring (CGM) devices are increasingly used in critical and non-critical care hospital units. The efficacy of CGM in assessing glucose control in adults with diabetic ketoacidosis (DKA) is unknown.

Methods: This single-center pilot study compared glycemic control by real-time CGM (Dexcom G6), capillary point-of-care (POC), and basic metabolic panel (BMP) during intravenous (IV) insulin treatment and after the resolution of DKA.

Traditional Chinese medicine Chaiqinchengqi decoction for patients with acute pancreatitis: A randomized clinical trial.

Background: Chaiqinchengqi decoction, a traditional Chinese medicine, has shown promising effects in in vitro, animal and preliminary small human studies for acute pancreatitis, but evidence of clinical practice is limited.

Purpose: To investigate whether Chaiqinchengqi decoction could improve clinical outcomes in patients with acute pancreatitis.

Study Design: Prospective, pragmatic, randomized controlled trial.

A Highly Bioactive Organic-Inorganic Nanoparticle for Activating Wnt10b Mediated Osteogenesis by Specifically Anchor CCN3 Protein.

The rapid and efficient bone regeneration is still in unsatisfactory outcomes, demonstrating alternative strategy and molecular mechanism is necessary. Nanoscale biomaterials have shown some promising results in enhancing bone regeneration, however, the detailed interaction mechanism between nanomaterial and cells/tissue formation is not clear. Herein, a molecular-based inorganic-organic nanomaterial poly(citrate-siloxane) (PCS) is reported which can rapidly enhance osteogenic differentiation and bone formation through a special interaction with the cellular surface communication network factor 3 (CCN3), further activating the Wnt10b/β-catenin signaling pathway.

Tracing microplastics in marine fish: Ecological threats and human exposure in the Bay of Bengal.

This research on microplastics (MPs) in marine environments, particularly in Bay of Bengal fish, underscores the limited comprehension of their accumulation and potential health and environmental consequences. The study investigated the abundance of MPs in the organs of nine marine fish species from the north Bay of Bengal, assessing their polymeric risks and implications for human health. The average MPs ingested by each individual was 32.

Reinforcing ion diffusion and controlling microcrack of nickel-rich cobalt-free single-crystalline cathodes via interfacial protection and bulk optimization.

Nickel-rich cobalt-free layered oxide cathode with Ni contents no fewer than 90 % has received extensive attention in the field of lithium-ion batteries due to its excellent specific capacity and low cost, but serious capacity degeneration induced by structural deterioration and interfacial instability greatly hamper their further development. Herein, the Sb-modified LiNiMnO materials from the interface to interior have been designed and fabricated to overcome the above issues. On the one hand, the introduction of Sb-ion in interior of grains can generate Sb-O chemical bond with high dissociation energy, which contributes to reinforce the chemical and structural stability.

A responsive cocktail nano-strategy breaking the immune excluded state enhances immunotherapy for triple negative breast cancer.

The exclusion of immune cells from the tumor can limit the effectiveness of immunotherapy in triple negative breast cancer (TNBC). The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway plays a crucial role in priming adaptive anti-tumor immunity through the production of type I interferons (IFNs), facilitating the maturation of dendritic cells (DCs) and the function of T cells. Although the increased expression of programmed death-ligand 1 (PD-L1) upon STING activation is favorable for amplifying the efficacy of immune checkpoint inhibitors (ICIs) and realizing combination therapy, the penetration barrier remains a major obstacle.

UBE2S, downregulated by miR-152-3p, facilitates prostate cancer progression through the PTEN-mediated AKT/mTOR pathway.

Objectives: In recent years, the incidence and mortality rates of prostate cancer (PCa) have still not been significantly reduced and the mechanisms of tumor onset and progression are still not fully understood. The pathogenic mechanisms and upstream regulation of UBE2S expression in prostate cancer have not been elucidated.

Methods: Here, we performed bioinformatic analysis of public databases to reveal the expression of UBE2S in PCa and its association with Gleason score, tumor staging, biochemical recurrence, and survival.

The Interplay Between Stigma and Asian Cultural Values in People with Parkinson's Disease and Their Caregivers.

Parkinson's Disease (PD), the second most prevalent neurodegenerative disorder globally, often carries stigma for those affected; however, stigma's impact on PD caregivers is not well understood. This study investigates PD stigma and its interplay with cultural values, as well as explores the role of depressive symptomatology in shaping help-seeking attitudes among individuals with PD and the provision of support by PD caregivers. Using cross-sectional data collected from people living with PD and their caregivers, this study examines how adherence to Asian values influences the link between self-stigma and help-seeking tendencies in PD patients, as well as how affiliate stigma is linked to caregivers' willingness to help.

Endogenetic Carbon Dot Strategy within Melamine-Formaldehyde Microspheres for Multifunctional Hybrid Fluorescence/Room-Temperature Phosphorescence Applications in Dry States and Aqueous Environments.

Developing hybrid fluorescence (FL)/room-temperature phosphorescent (RTP) materials in dry-state, aqueous, and organic solvents holds paramount importance in broadening their applications. However, it is extremely challenging due to dissolved oxygen and solvent-assisted relaxation causing RTP quenching in an aqueous environment and great dependence on SiO-based materials. Herein, an efficient endogenetic carbon dot (CD) strategy within melamine-formaldehyde (MF) microspheres to activate RTP of CDs has been proposed through the pyrolysis of isophthalic acid (IPA) molecules and branched-chain intra-microspheres.

Resveratrol ameliorates postoperative cognitive dysfunction in aged mice by regulating microglial polarization through CX3CL1/CX3CR1 signaling axis.

Postoperative cognitive dysfunction (POCD) is a common cognitive challenge faced by older adults. One of the key contributors to the development of POCD is neuroinflammation induced by microglia. Resveratrol has emerged as a promising candidate for the prevention of cognitive decline.

Harmless treatment of cyanide tailings by functional bacteria: Degradation of cyanide and the secondary pollutant ammonia nitrogen.

The eco-friendly treatment of cyanide tailings (CT) using microorganisms is a cost-effective and promising technology. However, this process often generates the secondary pollutants, such as ammonia nitrogen (NH-N), which can adversely impacts the surrounding environment. The accumulation of NH-N is also toxic to cyanide-degrading microorganisms, presenting a significant challenge in achieving simultaneous cyanide degradation and NH₄⁺-N mitigation.

Two mixed-valent cerium oxo clusters: synthesis, structure, and self-assembly.

Studies on cerium oxo clusters (CeOCs) are not only significant for understanding the redox and hydrolysis behaviors of Ce(III/IV) ions but also crucial for the rational synthesis of novel clusters and nanoceria with specific Ce(III)/Ce(IV) ratios. Here, two sets of reactions were conducted using cerium nitrate and HO-oxidized cerium nitrate, resulting in the formation of two distinct mixed-valent CeOCs [Ce Ce O(OH)(PhCO)(DMF)] (Ce) and [Ce Ce O(OH)(PhCO)(DMF)] (Ce). These two clusters exhibit different structures and Ce(III)/Ce(IV) ratios, demonstrating the critical role of cerium oxidation states and the occurrence of redox reactions in cluster formation.

Root-inspired, template-confined additive printing for fabricating high-robust conformal electronics.

Conformal electronic devices on freeform surface play a critical role in the emerging smart robotics, smart skins, and integrated sensing systems. However, their functional structures such as circuits tend to tear-off, break, or crack under mechanical or thermal influence when in service, thus limiting the application reliability of conformal electronics. Herein, inspired by the tree root system, template-confined additive (TCA) printing technology was presented for reliable fabrication of robust circuits.

Identification of a Flavanone 2-Hydroxylase Involved in Flavone -Glycoside Biosynthesis from .

Tea contains a variety of flavone -glycosides, which are important compounds that distinguish tea cultivars and tea categories. However, the biosynthesis pathway of flavone -glycosides in tea plant remains unknown, and the key enzymes involved have not been characterized. In this study, a liquid chromatography-mass spectrometry method to determine 9 flavone -glycosides was developed, and the accumulation patterns of 9 flavone -glycosides in tea plants were examined first.

Supplementation with Chinese herbal preparations protect the gut-liver axis of Hu sheep, promotes gut-liver circulation, regulates intestinal flora and immunity.

The gut-liver axis in ruminants can explain nutrient regulation, the gut-liver cycle, and immune function in ruminant biology through the gut microbe-gut metabolite-liver metabolite relationship. to investigate the effects of herbal feed additives on the gut-liver axis of Hu sheep. In this study, a broadly targeted UPLC-MS/MS metabolomics approach and 16s sequencing of gut microorganisms were used to detect, identify and quantify changes in ileal microorganisms, liver metabolites and ileal metabolites following the addition of Chinese herbal preparations.