Clinical and Radiological Outcomes of Transarterial Embolization for Adhesive Capsulitis.

Objective: To assess the effect of transarterial embolization (TAE) for adhesive capsulitis (AC) by evaluating clinical outcomes and changes in inflammation using magnetic resonance imaging (MRI).

Materials And Methods: Patients who had undergone TAE between August 2020 and August 2023 for AC refractory to conservative treatments without any invasive procedures for more than 3 months, and had undergone baseline and 3-month post-AC follow-up contrast-enhanced MRI evaluations, were included. A suspension mixture of 500 mg imipenem/cilastatin in 10 mL of iodinated contrast agent was used for TAE.

An epitope-directed mRNA vaccine inhibits tumor metastasis through the blockade of MICA/B α1/2 shedding.

Antigenic peptide-based mRNA vaccines have been explored for immunotherapeutic use in various types of cancer because of their advantages in activating durable and specific immune responses. However, their role in modulating tumor metastasis is still unclear. Here, we identify a conserved linear epitope-based peptide, Ma3P, located in the proteolytic region of major histocompatibility complex (MHC) class I-related chain A (MICA) α3 and further design mCM10-L, an mRNA vaccine that encodes the carrier protein CRM197 and 10 tandem repeats of Ma3P.

Causal relationship between sleep traits and risk of Epilepsy: A Mendelian randomization study.

Background: Observational studies have identified a strong correlation between epilepsy and sleep traits, highlighting their interactive relationship. However, no studies have specifically examined the associations between sleep traits and epilepsy. In this context, we conducted a Mendelian Randomization (MR) investigation to explore the causal nature of these associations.

A nanoplasmonic cell-on-a-chip for in situ monitoring of PD-L1 exosome-mediated immune modulation.

Despite the transformative impact of immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 pathway in cancer therapy, up to 80% of patients fail to respond, necessitating reliable predictive biomarkers to guide treatment decisions. Recent studies highlight the critical role of tumor-derived exosomal PD-L1 in immune evasion, and its potential as a diagnostic and prognostic biomarker in cancer immunotherapy. However, significant challenges remain in elucidating the functional roles of PD-L1 exosomes in immune suppression, as current methods lack the ability to precisely and simultaneously characterize and monitor exosome secretion and the corresponding immune modulation on site.

Mitochondrial ROS-associated integrated stress response is involved in arsenic-induced blood-testis barrier disruption and protective effect of melatonin.

Arsenic (As) is an environmental metalloid. Previous studies have demonstrated that As exposure resulted in decline of sperm quality. This study aimed to investigate the impact of exposure to As on blood-testis barrier (BTB) in a mouse model.

The SiP nanotubes as potential metal-free photocatalyst: a density functional theory study.

Hydrogen generation via photocatalytic water splitting holds significant potential as a strategy to tackle energy crises and environmental degradation. We investigated the electronic and photocatalytic properties of silicon phosphide (SiP) single-walled nanotubes as potential photocatalysts employing HSE06 hybrid density functional along with all-electron Gaussian basis sets. Relative to the monolayer, the band gap of nanotube is reduced (e.

Complications related to oral corticosteroid use in asthma patients: a retrospective cohort study.

Background: Asthma patients requiring oral corticosteroids (OCS) are at increased risk of adverse effects. Research focusing on asthma patients adhering to guideline-directed therapy remains limited. This study evaluates the adverse effects of corticosteroids in asthma patients treated with high-dose inhaled corticosteroids (ICS) who required additional OCS due to inadequate disease control.

Effectiveness of an ergonomic training with exercise program for work-related musculoskeletal disorders among hemodialysis nurses: A pilot randomized control trial.

Introduction: Hemodialysis nurses suffer a high prevalence of work-related musculoskeletal disorders due to the nursing job contents and high repetition. A practical ergonomic program was expected to improve their occupational health and musculoskeletal discomfort. This study developed an ergonomic training program with exercise and examined its effectiveness for musculoskeletal discomfort and muscle strength in hemodialysis nurses.

A VgrG2b fragment cleaved by caspase-11/4 promotes infection through suppressing the NLRP3 inflammasome.

The T6SS of plays an essential role in the establishment of chronic infections. Inflammasome-mediated inflammatory cytokines are crucial for host defense against bacterial infections. We found that infection activates the non-canonical inflammasome in macrophages, yet it inhibits the downstream activation of the NLRP3 inflammasome.

Association of ABCB1 C1236T Gene Polymorphisms With the Postoperative Analgesic Effects of Sufentanil and Morphine in Patients With Femoral Fractures.

Purpose: This study aimed to investigate the association between the ABCB1 C1236T gene polymorphism and the analgesic effects of sufentanil and morphine in patients undergoing surgery for femoral fractures (FFs).

Design: An experimental, exploratory design was used.

Methods: 400 patients who underwent FF surgery were randomly assigned to two groups using a random number table method: the morphine group and the non-morphine group.

Geniposidic Acid Targeting FXR "S332 and H447" Mediated Conformational Change to Upregulate CYPs and miR-19a-3p to Ameliorate Drug-Induced Liver Injury.

Drug-induced liver injury (DILI), caused by chemical drugs and traditional Chinese medicine, often leads to severe outcomes like liver failure due to a lack of early detection markers. Farnesoid X receptor (FXR), a key regulator of bile acid (BA) and cholesterol metabolism, is a potential therapeutic target. This study investigates the pathogenesis, markers, and treatment strategies for DILI, focusing on the hepatoprotective effects of geniposidic acid (GPA) from Gardenia jasminoides J.

Engineering of CD8 T cells with an HIV-specific synthetic notch receptor to secrete broadly therapeutic antibodies for combining antiviral humoral and cellular immune responses.

The application of immunotherapeutic strategies, such as chimeric antigen receptor-T cells and broadly neutralizing antibodies (bNAbs), for the treatment of human immunodeficiency virus (HIV) infection is hindered by the latent reservoirs and viral escape. Achieving long-term control of viral load in the absence of antiretroviral therapy requires a combination approach utilizing these immunotherapeutic strategies. For this purpose, we developed novel anti-HIV-1 synthetic Notch (synNotch) receptor-T cells, termed CD4-17b-VN, which express both a bNAb (VRC01) and a bispecific T cell-engaging protein (N6-αCD3) with antigenic control.

Acute Toxicity, Neurotoxic, Immunotoxic, and Behavioral Effects of Deltamethrin and Sulfamethoxazole in Adult Zebrafish: Insights into Chemical Interactions and Environmental Implications.

The increasing presence of antimicrobial agents and pesticides in aquatic environments raises concerns about their potential impacts on non-target organisms. Among these chemicals, deltamethrin (DM), a widely used pesticide, and sulfamethoxazole (SMX), an antimicrobial commonly detected in water bodies, pose significant ecological risks. This study investigates the acute toxicity, neurotoxic effects, oxidative stress responses, immune-related gene expression, and feeding behavior of adult zebrafish exposed to DM and SMX.

Per- and Poly-Fluoroalkyl Substances, and Organophosphate Flame Retardants in the Upper Yangtze River: Occurrence, Spatiotemporal Distribution, and Risk Assessment.

Contaminants of Emerging Concern (CECs), including per- and polyfluoroalkyl substances (PFASs) and organophosphate flame retardants (OPFRs), have raised global concerns due to their persistence, bioaccumulation potential, and toxicity. This study presents a comprehensive investigation of the occurrence, spatiotemporal distribution, potential sources, and the ecological and human health risks associated with 18 PFASs and 9 OPFRs in the surface waters of the upper Yangtze River, China. The water samples were collected from the main stream and five major tributaries (Min, Jinsha, Tuo, Jialing, and Wu Rivers) in 2022 and 2023.

Preparation of Electrochemical Sensors Based on Graphene/Ionic Liquids and the Quantitative Detection and Toxicity Evaluation of Tetracycline.

Tetracycline antibiotics, which are recognized as emerging environmental pollutants, are overused and retained in large quantities in terminal water bodies, seriously endangering the ecological environment and human health. Therefore, establishing a straightforward, rapid, and sensitive method for quantitatively detecting and evaluating the toxicity of tetracyclines is highly important. Compared with traditional detection methods, emerging electrochemical methods have many advantages, such as simplicity and rapidity.

Structural insights into human PNPase in health and disease.

Human polynucleotide phosphorylase (hPNPase) is a 3'-to-5' exoribonuclease located in mitochondria, where it plays crucial roles in RNA degradation and RNA import. Mutations in hPNPase can impair these functions, leading to various mitochondrial dysfunctions and diseases. However, the mechanisms by which hPNPase switches between its roles as an RNA-degrading enzyme and an RNA carrier, as well as how disease-associated mutations may affect these distinct functions, remain unclear.

Effect of Partial Root Drying Stress on Improvement in Tomato Production.

Several countries around the world are facing the issue of freshwater availability, where agriculture is highly dependent on irrigation, consuming 70% of this vital resource. Water availability is the most limiting factor for the crop production sector and one of the main regulators of the spatial distribution of plants. It is noted that in recent years, the methods of irrigation water application have been improved.

Correction: Wang et al. Identification and Verification of a Novel MAGI2-AS3/miRNA-374-5p/FOXO1 Network Associated with HBV-Related HCC. 2022, , 3466.

In the original publication [...

Temperature-Responsive Micro-Cross-Linking: A Novel Solution for Enhancing High-Temperature Viscosity and Settlement Stability of High-Density Cement Slurry.

In order to solve the problem of solid-phase particle settlement of high-density cement paste used in deep/ultra-deep wells, a temperature-responsive micro-cross-linking method was innovatively adopted to increase the viscosity and settlement stability of high-density cement paste at high temperatures. Through the self-developed suspension stabilizer and cross-linking agent to form micro-cross-linking gel at high temperature, the increase in high-temperature viscosity of cement paste was successfully realized without increasing the low-temperature viscosity of cement paste. Moreover, this micro-cross-linking reaction, together with the hydrophobic binding effect of the suspension stabilizer, strengthened the filamentary linkage network structure in the polymer solution with the formation of a lamellar linkage network structure.

Keloid Excision With Primary Closure Combined With Superficial Radiation Therapy (SRT-100).

Background: Surgery plus radiotherapy is associated with fewer recurrences after keloid treatment. However, the side effects of radiotherapy are of concern. Superficial radiation therapy has a low energy, targets the skin, and spares deeper structures, making it ideal for keloid treatment.

Association of depression, traditional risk factor control and genetic risk with incident cardiovascular disease among individuals with prediabetes: A population-based prospective study from UK biobank.

Background: The relationship between depression and cardiovascular disease (CVD) in individuals with prediabetes, its relative importance compared with traditional risk factors and whether genetic risk modifies this association remain unclear.

Aims: To explore the potential interactive effects of controlling traditional risk factors and depression on CVD, and to assess how depression compares with traditional risk factors in terms of its relative contribution to CVD risk in individuals with prediabetes.

Materials And Methods: We analysed a prospective cohort of 42,020 individuals from the UK Biobank, all free of prevalent CVD.

Genomic Characterization and Antimicrobial Resistance of ESBL-Producing, Isolates in Suzhou, China.

Background: The prevalence of third-generation cephalosporin-resistant and extended-spectrum beta-lactamases (ESBL) producing poses a significant global public health concern due to their resistance to multiple antibiotics; however, their prevalence and epidemiological patterns in China are not very well investigated.

Objective: This study aimed to investigate the molecular epidemiology, and antimicrobial susceptibility of ESBL-producing among clinical isolates in China.

Methods: Phenotypic ESBL-producing isolates were collected from in-patients at a non-tertiary hospital in Suzhou from 2018.

Effects of the stress hormone norepinephrine on the probiotic properties of : antibacterial colonization, anti-inflammation, and antioxidation.

Probiotics as antibiotic alternatives are unstable for use under stress in clinical applications. To explore the influence of catecholamine hormones on probiotic bacterial inhibition and antimicrobial activity, we tested the effects of norepinephrine (NE) on and in a mouse model. The results showed that in the presence of NE, 80% of strains showed increased growth rate and more than 80% of the strains indicated lower antimicrobial activity at 22 h.

Proximity extension assay revealed novel inflammatory biomarkers for follicular development and ovarian function: a prospective controlled study combining serum and follicular fluid.

Background: Many components in follicular fluid (FF), such as peptide hormones, cytokines, and steroids, undergo dynamic changes during folliculogenesis and have important roles in follicular development. Because systemic inflammation has also been found to contribute to diminished ovarian reserve (DOR) in previous studies, do certain serum/FF inflammatory biomarkers affect both follicular development and ovarian function?

Methods: Serum samples from the menstruation phase (n=26), serum samples from the ovulation phase (n=26), FF samples of mature oocytes (n=26), and FF samples of immature oocytes (n=10) were collected. Olink proteomic proximity extension assay (PEA) technology was used to compare the differentially expressed proteins (DEPs), and patients were divided into two subgroups-the normal ovarian reserve (NOR) group and the DOR group-for further bioinformatics analysis and verification by enzyme-linked immunosorbent assay (ELISA).