Publications by authors named "Wanchun Du"
Natural synergy: Oleanolic acid-curcumin co-assembled nanoparticles combat osteoarthritis.
Colloids Surf B Biointerfaces
January 2025
Article Synopsis
- Curcumin, a valuable natural product, faces challenges like low solubility and poor bioavailability, limiting its use as a functional food.
- The study introduces an oleanolic acid-curcumin (OLA-Cur) nano-slow-release system that enhances the water solubility and stability of both compounds, useful for treating osteoarthritis in mice.
- OLA-Cur nanoparticles effectively reduce inflammatory cytokines and improve cartilage health in osteoarthritis models, indicating potential for overcoming limitations of natural compounds in functional foods.
Aim: This study aimed to explore the effect of enriched rehabilitation (ER) on cognitive function and serum glutamate levels in patients with stroke.
Methods: Forty patients diagnosed with post-stroke cognitive impairment (PSCI), according to the inclusion criteria, and undergoing inpatient rehabilitation were enrolled in the study. Patients were randomly assigned to receive 8 weeks of ER treatment (ER group; = 20) or conventional medical treatment (CM group; = 20).