Publications by authors named "Wancheng Xu"
Article Synopsis
- MLL (mixed-lineage leukemia) family methyltransferases modify histone H3 at lysine 4, producing mono-, di-, and tri-methylation with specific functions, but how they achieve different methylation states is not fully understood.
- Researchers developed methods to compare the rates of these methylation steps and found that MLL proteins have distinct specificities based on their minimum protein complex.
- Structural analysis shows that two conserved tyrosine residues play a key role in determining product specificity, suggesting that variations in internal interactions within the MLL complex affect how these proteins function, indicating a broader rule for other similar enzymes.
