Publications by authors named "Wanchana Singhan"
Objectives: ChatGPT is an innovative artificial intelligence designed to enhance human activities and serve as a potent tool for information retrieval. This study aimed to evaluate the performance and limitation of ChatGPT on fourth-year pharmacy student examination.
Methods: This cross-sectional study was conducted on February 2023 at the Faculty of Pharmacy, Chiang Mai University, Thailand.
Article Synopsis
- * A study of 188 kidney transplant recipients assessed the impact of CYP3A5 genetic variations on tacrolimus IPV, revealing that 58.5% were expressers and 41.5% were nonexpressers of CYP3A5.
- * Results showed no significant differences in tacrolimus IPV between expressers and nonexpressers, although expressers had lower overall drug concentrations; IPV was unaffected by CYP3A5 variations over 6 to 12 months post-transplant.
Purposes: To gather available meropenem pharmacokinetics and define drug dosing regimens for Asian critically ill patients receiving CRRT.
Methods: All necessary pharmacokinetic and pharmacodynamic data from Asian population were gathered to develop mathematic models with first order elimination. Meropenem concentration-time profiles were calculated to evaluate efficacy based on the probability of target attainment (PTA) of 40%fT.
Aim: To estimate direct medical treatment costs in patients with pre-dialysis chronic kidney disease (CKD) in a district hospital and to analyze the factors that affected the treatment costs.
Patients And Methods: Data were retrospectively retrieved from the hospital database in the period from January 2015 to December 2017. Patients who were diagnosed with CKD and had visited ambulatory care services at least two times during the index year (January to December 2015) were included.
Background: Secondary hyperparathyroidism (SHPT) is associated with high incidences of cardiovascular disease, bone fracture, and mortality. This study was conducted to demonstrate the effectiveness of cinacalcet treatment on chronic kidney disease-mineral bone disorder (CKD-MBD) markers in chronic hemodialysis patients with severe SHPT.
Methods: In phase 1, 30 adult HD patients were randomized to cinacalcet or control groups for 12 weeks to explore the achievement of >30% reduction of iPTH.
Purpose: To evaluate the effect of direct hemoperfusion with polymyxin B immobilized cartridge (DHP-PMX) on meropenem pharmacokinetics in critically ill patients with sepsis requiring continuous venovenous hemofiltration (CVVH).
Material And Methods: After intravenous infusion of 1 g meropenem over 3 h repeated every 8 h for at least 3 doses, 2 serial blood and ultrafiltration fluid samples were collected: one over a dose interval of meropenem with DHP-PMX therapy; and the other on the following day over a dose interval of meropenem with no DHP-PMX therapy. Meropenem concentrations were measured by high performance liquid chromatography.