Publications by authors named "Wanbing Dai"
Postoperative cognitive dysfunction (POCD) is a prevalent neurological complication that can impair learning and memory for days, months, or even years after anesthesia/surgery. POCD is strongly associated with an altered composition of the gut microbiota (dysbiosis), but the accompanying metabolic changes and their role in gut-brain communication and POCD pathogenesis remain unclear. Here, the present study reports that anesthesia/surgery in aged mice induces elevated intestinal indoleamine 2,3-dioxygenase (IDO) expression and activity, which shifts intestinal tryptophan (TRP) metabolism toward more IDO-catalyzed kynurenine (KYN) and less gut bacteria-catabolized indoleacetic acid (IAA).
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- Pain sensitivity is influenced by age and physiological state, with older mice showing more severe pain responses than younger ones following injury.
- The study found that aged mice had a higher baseline pain threshold but exhibited greater allodynia and hyperalgesia after chronic pain was induced compared to younger mice.
- RAMP1, a spinal receptor involved in pain transmission, plays a key role in this age-dependent pain sensitivity, and targeting RAMP1 may help in developing treatments for chronic pain in older adults.
Stereotaxic injection of a specific brain region constitutes a fundamental experimental technique in basic neuroscience. Researchers commonly base their choice of stereotaxic injection parameters on mouse brain atlases or published materials that employed various populations/ages of mice and different stereotaxic equipment, necessitating further validation of the stereotaxic coordinate parameters. The efficacy of calcium imaging, chemogenetic, and optogenetic manipulations relies on the precise expression of reporter genes within the region of interest, often requiring several weeks of effort.
View Article and Find Full Text PDFBackground: Reversible loss of consciousness is the primary therapeutic endpoint of general anesthesia; however, the drug-invariant mechanisms underlying anesthetic-induced unconsciousness are still unclear. This study aimed to investigate the static, dynamic, topological and organizational changes in functional brain network induced by five clinically-used general anesthetics in the rat brain.
Method: Male Sprague-Dawley rats (n = 57) were randomly allocated to received propofol, isoflurane, ketamine, dexmedetomidine, or combined isoflurane plus dexmedetomidine anesthesia.
Article Synopsis
- * A total of 708 patients were divided into two groups: one received butorphanol injections while the other received saline; results showed a significantly lower incidence of EA in the butorphanol group (24.3% vs. 31.4%).
- * Other findings indicated longer times to recover spontaneous breathing and extubation in the butorphanol group, but improved hemodynamic stability and less hypotension compared to the control, leading to a smoother recovery without prolonging the
Background: Nowadays, pediatric liver transplantation (PLT) has become an effective strategy for treating various acute or chronic end-stage liver diseases and inherited metabolic diseases. Many experts have already concluded the current challenges and future directions of PLT. However, no detailed analysis of the publication landscape has substantiated these proposed opinions.
View Article and Find Full Text PDFStudy Objectives: To evaluate sepsis-associated encephalopathy (SAE) research and to quantitatively and qualitatively predict research hot spots using bibliometric analysis.
Methods: We extracted relevant publications from the Web of Science Core Collection on July 28, 2021. We investigated the retrieved data by bibliometric analysis (e.
Background: Aging is one of the most important risk factors of postoperative cognitive dysfunction (POCD); however, the mechanisms are still not completely understood. In this study, we explore the roles of matrix metalloproteinase-9 (MMP-9) in aged mice with POCD.
Methods: Appendectomy was performed in 18-month-old C57BL/6 and MMP-9 mice under anesthesia to establish the POCD model.
Background: Although electroacupuncture is widely used in chronic pain management, it is quite controversial due to its unclear mechanism. We hypothesised that EA alleviates pain by inhibiting degradation of the ecto-nucleotidase prostatic acid phosphatase (PAP) and facilitating ATP dephosphorylation in dorsal root ganglions (DRGs).
Methods: We applied EA in male C57 mice subjected to chronic constriction injury (CCI) and assessed extracellular ATP and 5'-nucleotidease expression in DRGs.
Purpose: Aging populations and increasing quality of life requirements have attracted growing efforts to study chronic postsurgical pain (CPSP). However, a diverse range of factors are involved in CPSP development, which complicates efforts to predict and treat this disease. To advance research in this field, our study aimed to use bibliometric analysis to quantitatively and qualitatively evaluate CPSP research and predict research hot spots over the last 10 years.
View Article and Find Full Text PDFBackground: Femoroacetabular impingement (FAI) has attracted increasing attention over the past few decades. We aim to evaluate FAI research and predict research hot spots quantitatively and qualitatively.
Methods: The publications in FAI research between 2000 and 2019 were assimilated from the Web of Science Core Collection of Clarivate Analytics.
Background: In pediatric living-donor liver transplantation, lactated Ringer's solution and normal saline are commonly used for intraoperative fluid management, but the comparative clinical outcomes remain uncertain.
Aims: To compare the effect between lactated Ringer's solution and normal saline for intraoperative volume replacement on clinical outcomes among pediatric living-donor liver transplantation patients.
Methods: This single-center, retrospective trial study enrolled children who received either lactated Ringer's solution or normal saline during living-donor liver transplantation between January 2010 and August 2016.
Background: Although sedation during gastrointestinal endoscopy is widely used in China, the characteristics of sedation use, including regional distribution, personnel composition, equipment used, and drug selection, remain unclear. The present study aimed to provide insights into the current practice and regional distribution of sedation for gastrointestinal endoscopy in China.
Methods: A questionnaire consisting of 19 items was distributed to directors of anaesthesiology departments and anaesthesiologists in charge of endoscopic sedation units in mainland China through WeChat.
Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice.
Mediators Inflamm
January 2021
Article Synopsis
- - Postoperative cognitive dysfunction is linked to higher mortality and morbidity in patients, particularly influenced by multiple surgeries or anesthesia during neurodevelopment, compared to single procedures in adults.
- - The study focused on adult mice undergoing multiple laparotomies in a short timeframe to explore the effects on cognitive function, examining central nervous system inflammation and cholinergic markers.
- - Findings indicated that while there was increased inflammation in the hippocampus after surgeries, adult mice did not experience cognitive decline or changes in cholinergic markers, suggesting that multiple anesthetic procedures in adults may not impair cognitive function.