Integrated network pharmacology and pharmacological investigations to discover the active compounds of Toona sinensis pericarps against diabetic nephropathy.

Ethnopharmacological Relevance: Toona sinensis (A. Juss.) Roem.

Traditional Uses, Chemical Constituents and Pharmacological Activities of the Plant.

(A. Juss.) Roem.

Optimization of Cutting Parameters for Deep Hole Boring of Ti-6Al-4V Deep Bottle Hole.

In this study, the cutting parameters for machining deep bottle holes (deep holes with complex profiles and length-to-diameter ratio greater than 10) were optimized based on cutting simulation, a regression analysis genetic algorithm, and experimental validation. The influence of cutting parameters on cutting force and cutting temperature was analyzed using the response surface method (RSM), and the regression prediction model of cutting parameters with cutting force and most cutting temperature was established. Based on this model, multi-objective optimization of cutting force and material removal rate was carried out based on a genetic algorithm, and a set of optimal cutting parameters ( = 139.

Design, synthesis, activity and molecular dynamics studies of 1,3,4-thiadiazole derivatives as selective allosteric inhibitors of SHP2 for the treatment of cancer.

Overexpression or gene mutation of SHP2 is closely linked with a variety of cancers and has been identified as a crucial anticancer target. In the study, we took SHP2 allosteric inhibitor SHP099 as the lead compound, and 32 1,3,4-thiadiazole derivatives were identified as selective allosteric inhibitors of SHP2. In vitro enzyme activity test showed that some compounds had high inhibition on full length SHP2, and almost no activity on homologous protein SHP1, exhibiting high selectivity.

Functional Separator Enabled by Covalent Organic Frameworks for High-Performance Li Metal Batteries.

Uncontrolled ion transport and susceptible SEI films are the key factors that induce lithium dendrite growth, which hinders the development of lithium metal batteries (LMBs). Herein, a TpPa-2SO H covalent organic framework (COF) nanosheet adhered cellulose nanofibers (CNF) on the polypropylene separator (COF@PP) is successfully designed as a battery separator to respond to the aforementioned issues. The COF@PP displays dual-functional characteristics with the aligned nanochannels and abundant functional groups of COFs, which can simultaneously modulate ion transport and SEI film components to build robust lithium metal anodes.

Dual-Band Electrochromic Optical Modulation Improved by a Precise Control of Lithium Content in LiTiO.

Dual-band electrochromic smart windows that can dynamically and independently control incident solar irradiation and visible light are envisioned as intelligent technology to reduce power consumption of buildings. However, there is still a great challenge to put the dual-band electrochromic technology into practice due to some limits in material systems and preparation techniques. Herein, a new electrochromic material of LiTiO is developed to implement the dual-band optical modulation behavior, which could be further improved by a precise control of the lithium content in the active material.

Terpenoids from the Seeds of and Their Ability to Attenuate High Glucose-Induced Oxidative Stress and Inflammation in Rat Glomerular Mesangial Cells.

(A. Juss.) Roem is an edible medicinal plant that belongs to the genus within the Meliaceae family.

Shakedown Analysis and Experimental Study of Thermal Barrier Coatings.

Interfacial stress-strain fields become complicated in thermal barrier coatings (TBCs) under cyclic thermal loading, which affects the stability and spalling failure of TBCs directly. The convex and concave interfacial structures of TBCs were approximated as a multilayer cylinder model, and an analytical method of TBCs for shakedown analysis was established. A series of 8-YSZ TBC specimens were prepared by the plasma spraying process, followed by isothermal and thermal shock tests.

Structural characterization of a pectic polysaccharide from laoshan green tea and its inhibitory effects on the production of NO, TNF- and IL-6.

A novel pectic polysaccharide, named GTPS3-1, was isolated and purified from Laoshan green tea polysaccharide (GTPS) through DEAE Sepharose Fast Flow and Sephacryl S-300 columns, its structure was characterized and its anti-inflammatory activity was explored. GTPS3-1, with a molecular weight of 26.05 kDa, was mainly composed of galacturonic acid, galactose, rhamnose and arabinose in a molar ratio of 4.

Study on the Microstructure and Mechanical Properties of Diamond Particle-Reinforced Copper-Iron Sandwich Composites Prepared by Powder Metallurgy.

Synthetic diamond particle-reinforced copper-iron composites (SD/Cu-Fe) were produced by the powder metallurgical method for stone cutting applications, and the microstructure, density, compactness, hardness, flexure strength, and wear resistance of the composites were characterized in this work. The results showed that the diamond particles were relatively uniformly distributed in most areas of the copper matrix and the crystal shape of diamond particles were relatively intact in the sintering temperature range from 740 °C to 780 °C. The interfaces between the diamond particles and copper matrix, as well as the interfaces between the copper matrix and iron layer, were well bonded without significant gaps.

Layer-dependent electronic and optical properties of tin monoxide: a potential candidate in photovoltaic applications.

Tunable band gaps make two-dimensional (2D) SnO a promising candidate for a wide variety of applications in optoelectronic devices. In this work, we calculated the structural, electronic, and optical properties of monolayer and mutilayer SnO up to seven layers based on density functional theory. We found that the band gaps of SnO can vary from 0.

Identification of potential target endoribonuclease NSP15 inhibitors of SARS-COV-2 from natural products through high-throughput virtual screening and molecular dynamics simulation.

SARS-CoV-2 wreaks havoc around the world, triggering the COVID-19 pandemic. It has been confirmed that the endoribonuclease NSP15 is crucial to the viral replication, and thus identified as a potential drug target against COVID-19. The NSP15 protein was used as the target to conduct high-throughput virtual screening on 30,926 natural products from the NPASS database to identify potential NSP15 inhibitors.

Self-Driven Infrared Electrochromic Device with Tunable Optical and Thermal Management.

Electrochromic devices (ECDs) exhibiting tunable optical and thermal modulation in the infrared (IR) region have attracted extensive attention in recent years due to their attractive application prospects in both military and civilian settings. However, considering the continuous energy supply needed for driving the device operation, it is desired to develop advanced IR-ECDs with low energy consumption. Herein, a flexible self-driven IR-ECD is constructed for achieving variable optical and thermal management in a low-energy mode.

Cytotoxicity and polyol pathway inhibitory activities of chemical constituents isolated from the pericarp of .

is a medicinal and edible plant that belongs to the genus of family Meliaceae. Phytochemical investigations carried out on this plant, seven apotirucallane-type triterpenoids (), two cycloartane-type triterpenoids (), four sterols (), two sesquiterpenes (), four phenols (), and one lignin () were isolated from the pericarp of by silica gel column and preparative middle pressure liquid chromatography. Their structures were identified by interpretation of NMR and comparison with those reported in the literature.

Therapeutic Effect of Calcipotriol Pickering Nanoemulsions Prepared by Exopolysaccharides Produced by FYS Strain on Psoriasis.

Purpose: Many exopolysaccharides (EPS) have significant emulsifying activity. Some EPS produced by the marine bacterial strain FYS have stronger emulsifying activity in the form of nanoparticles, suggesting that they could potentially form Pickering emulsions. We prepared novel EPS/CT Pickering nanoemulsions (ECPN) with EPS as emulsifiers and assessed their ability to ameliorate the poor permeability of calcipotriol (CT) in skin affected by psoriasis vulgaris.

Recovery of immune activity by administration of polysaccharides of and its characterization of major component.

The polysaccharides were acquired from the seeds of by hot water extraction, ethanol precipitation, decoloration with macroporous 900 resin, and deproteinization with sevag reagent, which possessed significantly immunomodulatory activity on the levels of IgA, IgG, and IgM, the relative indices of thymus and spleen, and the phagocytosis index of mice in seeds polysaccharides (TSP) were separated and purified using DEAE-52 cellulose and Sephacryl S-300 column chromatography to obtain TSP-3a characterized of molecular weight, monosaccharides composition, and other preliminary structural features. TSP-3a (758.6 kDa) mainly contained Man, GalN, GlcA, Rha, Glc, Gal, Ara, and Fuc in a molar ratio of 0.

Polyphenols from Toona sinensiss Seeds Alleviate Neuroinflammation Induced by 6-Hydroxydopamine Through Suppressing p38 MAPK Signaling Pathway in a Rat Model of Parkinson's Disease.

Polyphenols from Toona sinensis seeds (PTSS) have demonstrated anti-inflammatory effects in various diseases, while the anti-neuroinflammatory effects still remain to be investigated. We aimed to investigate the effects of PTSS on Parkinson's disease and underlying mechanisms using a rat model. We employed 6-hydroxydopamine (6-OHDA) to male Sprague Dawley (SD) rats and PC12 cells to construct the in vivo and vitro models of PD and dopaminergic (DA) neuron injury, respectively.

Two New Apotirucallane-Type Triterpenoids from the Pericarp of and Their Ability to Reduce Oxidative Stress in Rat Glomerular Mesangial Cells Cultured under High-Glucose Conditions.

Hyperglycemia is a strong risk factor for chronic complications of diabetes. Hyperglycemic conditions foster not only the production of reactive oxygen species (ROS), but also the consumption of antioxidants, leading to oxidative stress and promoting the occurrence and progression of complications. During our continuous search for antioxidant constituents from the pericarp of (A.

Extraction, Characterization and Antioxidant Activity in vitro of Proteins from .

(PSAF) is the seed of L. of the Liliaceae family. The purpose of this study was to extract, characterize, and evaluate the antioxidant activity in vitro of proteins.

Protective Effects of Kaempferitrin on Advanced Glycation End Products Induce Mesangial Cell Apoptosis and Oxidative Stress.

Advanced glycation end products (AGEs) and the receptor for AGEs (RAGE) both play important roles in diabetic nephropathy (DN). Previous studies have identified glomerular mesangial cells (GMCs) injury as a key early risk factor in the development of DN. Kaempferitrin (KM) is a potent antioxidant with hypoglycemic action.

The lipopeptide 6-2 produced by Bacillus amyloliquefaciens anti-CA has potent activity against the biofilm-forming organisms.

Both the whole cells and protoplasts of Pseudomonas aeruginosa PAO1 and Bacillus cereus, two biofilm-forming bacteria, were disrupted by the lipopeptide 6-2 produced by Bacillus amyloliquefaciens anti-CA. The lipopeptide 6-2 could also effectively inhibit the formation of biofilms and disperse pre-formed biofilms. Live/dead staining of the biofilms grown in the absence or presence of the lipopeptide 6-2 showed that more dead bacterial cells in the presence of the lipopeptide than those in the absence of the lipopeptide and biofilm formation was greatly reduced by the lipopeptide 6-2.

Cyclocarya paliurus extract alleviates diabetic nephropathy by inhibiting oxidative stress and aldose reductase.

Diabetes is the leading cause of end-stage renal disease because diabetic nephropathy (DN) develops in 30-40% of the patients. This study investigated the protective effect of the aqueous extract from leaves of Cyclocarya paliurus (Batal.) Iljinsk (ACP) on DN by inhibiting oxidative stress and aldose reductase (AR) activity.

Strength degradation and lifetime prediction of dental zirconia ceramics under cyclic normal loading.

Clinical cases show that zirconia restoration could happen fracture by accident under overloading after using a period of time. The purpose of this study is to research mechanical behavior and predict lifetime of dental zirconia ceramics under cyclic normal contact loading with experiments. Cyclic normal contact loading test and three point bending test are carried on specimens made of two brands of dental zirconia ceramic to obtain flexure strength and damage degree after different number of loading cycles.

[Study on correlation between relative density and kinematical viscosity of concentration for Yuxianling granules].

Objective: To study the relation between relative density and kinematical viscosity of the concentration for Yuxianling granules.

Method: The relative density and kinematical viscosity by alkali burette of the concentration were investigated. The connection between kinematical viscosity and spray drying, also and temperature of the concentration was respected.