[Influencing Mechanism of Precipitation Pollution Intensity in Qinhuai River Basin Based on Random Forest].

Analyzing the distribution characteristics of precipitation pollution intensity in the basin and identifying the main factors affecting the precipitation pollution intensity are the important basis for realizing the accurate management of diffused pollution. Based on the surface water quality data from four typical sections of the main stream of Qinhuai River Basin and rainfall data collected from 2021 to 2022, the distribution characteristics of precipitation pollution intensity in the basin were analyzed, and representative natural and social factors were selected to construct models of the precipitation pollution intensity of ammonia nitrogen （NH-N）, permanganate index, and total phosphorus （TP） based on random forest algorithm. Additionally, the main driving factors of precipitation pollution intensity were identified, and the influencing mechanism was analyzed.

Zinc Mitigates the Combined Neurotoxicity of Binary Metal Mixtures via Mitophagy and Mitochondrial Fusion.

Environmental metal mixtures can cause combined neurotoxicity, but the underlying mechanism remains unclear. Mitochondria are crucial for energy metabolism in the nervous system, and their dysfunction leads to neurodegeneration. Zinc (Zn) is a coenzyme of many mitochondrial enzymes that controls mitochondrial function.

Tim-1-mediated extracellular matrix promotes the development of hepatocellular carcinoma.

Tim-1 (T-cell immunoglobulin and mucin domain 1), also known as Kim-1 (kidney injury molecule 1) or hepatitis A virus cellular receptor 1 (HAVCR1), is a transmembrane protein expressed on various immune and epithelial cells. It plays a role in modulating inflammatory and immune responses. In this study, we find that Tim-1 is overexpressed in hepatocellular carcinoma (HCC) samples and that its expression is significantly correlated with postoperative survival.

Enhancing prognostic guidance in renal light-chain amyloidosis: a new staging system incorporating pathological characters.

Background: Advancements in treatment regimens have led to improved outcomes in renal Immunoglobulin light-chain amyloidosis. Nevertheless, a subset of patients may still experience renal adverse events despite achieving hematologic very good partial response or better. This discrepancy may be attributed to the deposition pattern of amyloid in renal tissue.

Assessment of circulating proteins in thyroid cancer: Proteome-wide Mendelian randomization and colocalization analysis.

The causality between circulating proteins and thyroid cancer (TC) remains unclear. We employed five large-scale circulating proteomic genome-wide association studies (GWASs) with up to 100,000 participants and a TC meta-GWAS (n = 3,418, n = 292,703) to conduct proteome-wide Mendelian randomization (MR) and Bayesian colocalization analysis. Protein and gene expressions were validated in thyroid tissue.

Advancing precision medicine in immunoglobulin light-chain amyloidosis: a novel prognostic model incorporating multi-organ indicators.

To develop a more accurate prognostic model that incorporates indicators of multi-organ involvement for immunoglobulin light-chain (AL) Amyloidosis patients. Biopsy-proven AL amyloidosis patients between January 1, 2012, and February 28, 2023, were enrolled and randomly divided into a training set and a test set at a ratio of 7:3. Prognostic indicators that comprehensively cover cardiac, renal, and hepatic involvement were identified in the training set by random survival forest (RSF).

[Cordycepin, a metabolite of , inhibits xenograft tumor growth of tongue squamous cell carcinoma in nude mice].

Objective: To evaluate the inhibitory effect of cordycepin on oral cancer xenograft in nude mice and explore the underlying mechanisms.

Methods: Sixteen BALB/c mice bearing subcutaneous human tongue squamous cell carcinoma (TSCC) TCA-8113 cell xenografts were randomized into model group and cordycepin treatment group for daily treatment with saline and cordycepin for 4 weeks. After the treatment, the tumor xenografts were dissected and weighed to assess the tumor inhibition rate.

Comparison of the basic processes of aerobic, anaerobic, and aerobic-anaerobic coupling composting of Chinese medicinal herbal residues.

Chinese medicinal herbal residues (CMHRs) are waste generated after extracting Chinese medicinal materials, and they can be used as a renewable bioresource. This study aimed to evaluate the potential of aerobic composting (AC), anaerobic digestion (AD), and aerobic-anaerobic coupling composting (AACC) for the treatment of CMHRs. CMHRs were mixed with sheep manure and biochar, and composted separately under AC, AD, and AACC conditions for 42 days.

Absorption and Transport Mechanism of Red Meat-Derived -glycolylneuraminic Acid and Its Damage to Intestinal Barrier Function through the NF-κB Signaling Pathway.

-glycolylneuraminic acid (Neu5Gc) is a specific factor in red meat that induces intestinal disease. Our aim was to investigate the effect of Neu5Gc on the intestinal barrier as well as its mechanism of endocytosis and exocytosis. Ten specific inhibitors were used to explore the mechanism of Neu5Gc endocytosis and exocytosis by Caco-2 cells.

Listening to voices from multiple sources: A qualitative text analysis of the emotional experiences of women living with breast cancer in China.

Background: Receiving a breast cancer diagnosis and treatment is both a physical and emotional journey. Previous studies using single-source data have revealed common and culture-specific emotional experiences of patients living with breast cancer. However, few studies have combined such data from multiple sources.

Risk Factors for Melioidosis Mortality and Epidemics: A Multicentre, 10-Year Retrospective Cohort Study in Northern Hainan.

Introduction: Burkholderia pseudomallei is a gram-negative environmental bacterium and aetiological agent of melioidosis, a tropical infectious disease with diverse clinical presentations. We aimed to describe the epidemiological and clinical characteristics of melioidosis in northern Hainan and to determine the meteorological factors affecting its morbidity.

Methods: We conducted a retrospective, multicentre, observational cohort study of 90 patients with melioidosis admitted to four general hospitals in northern Hainan from 2010 to 2020.

An approach of gene regulatory network construction using mixed entropy optimizing context-related likelihood mutual information.

Motivation: The question of how to construct gene regulatory networks has long been a focus of biological research. Mutual information can be used to measure nonlinear relationships, and it has been widely used in the construction of gene regulatory networks. However, this method cannot measure indirect regulatory relationships under the influence of multiple genes, which reduces the accuracy of inferring gene regulatory networks.

Case report: Fetal cervical immature teratoma and copy number variations.

Fetal cervical teratoma is a rare congenital neck tumor. Here, we report a case of a fetus with an anterior solid neck tumor that was confirmed to have an immature teratoma by histology. A duplication was found at chromosome 14q24.

Cluster Analysis Algorithm in the Analysis of College Students' Mental Health Education.

With the rapid development of curricula, a large number of studies are emerging to assist in the development of curricula. But in an information society, in the face of rapid learning and increased life expectancy, students face the pressure not to forget; the mental health status as a result of our curricula is closely related to our learning. The research and application of the integration algorithm plays an important role in the analysis of the mental health education system.

7-deacetyl-gedunin suppresses proliferation of Human rheumatoid arthritis synovial fibroblast through activation of Nrf2/ARE signaling.

Rheumatoid arthritis (RA) is an chronic autoimmune disease and characterized by high incidence. However, there is no effective therapies for RA. Therefore, it is urgent to discover new drugs for RA treatment.

Research on Diagnosis Prediction of Traditional Chinese Medicine Diseases Based on Improved Bayesian Combination Model.

Traditional Chinese Medicine (TCM) clinical intelligent decision-making assistance has been a research hotspot in recent years. However, the recommendations of TCM disease diagnosis based on the current symptoms are difficult to achieve a good accuracy rate because of the ambiguity of the names of TCM diseases. The medical record data downloaded from ancient and modern medical records cloud platform developed by the Institute of Medical Information on TCM of the Chinese Academy of Chinese Medical Sciences (CACMC) and the practice guidelines data in the TCM clinical decision supporting system were utilized as the corpus.

[Effect of oral GR-1 and RC-14 on vaginal Group B colonization and vaginal microbiome in late pregnancy].

Objective: To explore the effects of intervention with oral probiotic GR-1 and RC-14 on vaginal Group B (GBS) colonization, pregnancy outcome and vaginal microbiome in GBS-positive women in the third trimester of pregnancy.

Methods: This study were conducted among 155 women in the third trimester of pregnancy with positive results of GBS culture in the Outpatient Department of Zhujiang Hospital from March to November, 2019. After excluding 32 patients who received lactobacillus intervention for less than 2 weeks or underwent postpartum GBS retesting, the women were divided into oral probiotics intervention group (60 cases) and non-intervention group (63 cases).

Effect of prolonged expressive writing on health outcomes in breast cancer patients receiving chemotherapy: a multicenter randomized controlled trial.

Purpose: This study aims to evaluate the effects of prolonged expressive writing on health outcomes in breast cancer patients undergoing chemotherapy to help understand how the dosage of an expressive writing intervention might moderate its effects.

Methods: A total of 112 breast cancer patients undergoing chemotherapy were randomly allocated to the expressive writing group (n = 56) or the prolonged expressive writing group (n = 56). The expressive writing group received the standard expressive writing intervention based on Pennebaker's prompt to write for at least 20 min over four consecutive days (4 sessions).

Illusory perception of auditory filled duration is task- and context-dependent.

In filled-duration illusion, a continuous (long) tone or an auditory sequence with multiple clicks is typically perceived as longer than the same physical duration (i.e., empty interval) enclosed by two auditory clicks.

The Roles of Attentional Shifts and Attentional Reengagement in Resolving The Spatial Compatibility Effect in Tactile Simon-like Tasks.

The Simon effect refers to the acceleration of choice responses when the target position and response location are consistent compared with scenarios in which they are inconsistent, even if the target position is not relevant to the response. Here, we provide the first demonstration that the tactile Simon-like effect operates in an attention-shifting manner. In unimodal scenarios (Experiments 1-4), for the tactile direction task, the spatial compatibility effect was absent in the focused-attention condition but maintained in the divided-attention condition.

Trapping two types of particles by modified circular Airy beams.

The radiation force of modified circular Airy beams (MCAB) exerted on both a high-refractive-index particle and a low-refractive-index particle are analyzed in this paper. Our results show that the two kinds of particles can be simultaneously stably trapped by MCAB at different positions. Compared with the common circular Airy beams (CAB) with the same parameters, trapping forces on the two kinds of particles are greatly increased because of the enhanced abruptly autofocusing property and the appearance of hollow region in MCAB.

Propagation characteristics of the modified circular Airy beam.

We have proposed a kind of modified circular Airy beam (MCAB) based upon a modification of the Fourier spectrum of circular Airy beams (CAB) in this paper. Unlike most abruptly autofocusing beams, the position of peak intensity of MCAB can be moved to any rings behind. Two apodization parameters are introduced to describe the propagation characteristics of MCAB.