Development and characteristics of temperature-sensitive liposomes for vinorelbine bitartrate.

A novel liposome with temperature-sensitivity for vinorelbine bitartrate (VB) was designed to enhance VB targeted delivery and antitumor effect. Liposomes without drugs were prepared by thin film hydration, and then VB was entrapped into liposomes by pH gradient loading method. The mean particle size of the liposomes was about 100 nm, and the drug entrapment efficiency was more than 90%.

Photosensitive cross-linked block copolymers with controllable release.

We intend to form photosensitive block copolymer micelles for controllable release of encapsulated substances. Here, we designed and synthesized a new photocleavable cross-linker (2-nitrophenyl ethylene glycol dimethacrylate) for methyl methacrylate (MMA) atom transfer radical polymerization. Four different ratios (0:1, 1:26, 1:16, 1:8.

[Hypoglycemic effects of bis(maltolato)oxovanadium administered by different routes upon diabetic rats].

Objective: To study the hypoglycemic effects of bis(maltolato) oxovanadium (IV) (BMOV) after administration on diabetic rats by different routines, and its possible mechanisms.

Methods: Diabetic rats were created by intraperitoneal administration of Alloxan. BMOV was administered by single intraperitoneal injection, oral gavage, subcutaneous injection, bolus intravenous injection, or slow bolus intravenous injection(7-8 min).

[Effect of quercetin on the acyclovir intestinal absorption].

Objective: To study the effect of quercetin on acyclovir intestinal absorption.

Methods: The everted gut sac and in vitro intestinal absorption tests were performed. The acyclovir transport quantity was determined by HPLC method.