Publications by authors named "Wan-xin Wu"

Breast cancer is one of the most common malignant tumors among females, and can seriously affect the physical and mental health and even threaten the lives of women. Recently, research has demonstrated that microRNAs (miRNAs), as a new method of regulation, have been shown to have oncogenic and tumor‑suppressive functions in human breast cancer. Detection of their expression may lead to the identification of novel markers for breast cancer.

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Breast cancer is one of the most common malignant diseases in women. The main cause of death from breast cancer is its metastases at distant sites in the body. Interleukin-33 (IL-33) is a cytokine of the IL-1 family and found overexpressed in various cancers.

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SCY1-like 1-binding protein 1 (SCYL1BP1) is a newly identified transcriptional activator domain containing protein with many unknown biological functions. Recently emerging evidence has revealed that it is a novel regulator of the p53 pathway, which is very important for the development of human cancer. However, the effects of SCYL1BP1 on human lung squamous carcinoma cell biological behavior remain poorly understood.

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Article Synopsis
  • - The study aimed to investigate the relationship between liver fibrosis levels and biochemical parameters in patients with advanced schistosomiasis using liver biopsy and B ultrasound imaging.
  • - Among 48 patients, the findings showed no correlation between liver fibrosis levels from biopsy and biochemical parameters, but a weak correlation was seen with ultrasound and certain biochemical markers like GGT, AKP, LN, and PC-III.
  • - The results suggest that B ultrasound is a more effective noninvasive way to assess liver fibrosis, and when combined with specific biochemical markers, it provides a clearer picture of liver health.
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Background: Schistosoma japonicum causes marked liver fibrosis, while lethal syndromes present in advanced schistosomiasis patients. Its management depends on the degree of fibrosis present.

Patients And Methods: Fifty-two patients were recruited to assess the diagnostic value of bio-markers in patients with advanced schistosomiasis japonica.

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Objective: To establish the serial cell lines, derived from the same parental gallbladder cancer cell line GBC-SD, with highly metastatic potential via different routes and characterize their biological behaviors to understand the different metastasis mechanisms via lymph and blood.

Methods: The spleen-liver metastasis model and footpad-inguinal lymph node metastasis model were established. GBC-SD was injected into spleen or footpad of nude mice.

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Objectives: To evaluate the relationship between epithelial-mesenchymal transition and basal cell-like phenotype breast cancer (BLBC).

Methods: Three hundred and eighty two cases of breast cancers including basal cell-like, luminal A, luminal B and Her-2 subtypes were collected from 458 cases of invasive breast cancers based on their immunophenotypes. They were then stained immunohistochemically with FOXC-2, vimentin, Syndecan-1 and E-cadherin.

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Objective: To study the clinicopathologic characteristics of basal-like immunophenotype breast cancer (BLBC).

Methods: 458 cases of female infiltrative breast cancer were studied using immunohistochemical staining with an antibody panel of ER, PR, HER2, Ki-67, CK5/6, CK14 and epidermal growth factor receptor (EGFR) and were classified basing on the immunophenotypes. The clinicopathologic characteristics were compared with other immunophenotypes of breast cancer.

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