Publications by authors named "Wan-nan Li"

Essential oils of sunflower receptacles (SEOs) have antibacterial and antioxidant potential. However, the differences of biological activities from the different varieties of sunflowers have not been studied till now. The purpose of this study was to compare the differences of chemical compounds, antioxidant activities, and inhibitory activities against xanthine oxidase (XO) of SEOs from the three varieties of sunflowers including LD5009, SH363, and S606.

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Studied the optimum extraction process of polysaccharide from Phaeoporus obliquus and the effect of Phaeoporus obliquus polysaccharide on carbon tetrachloride (CCl)- or alcohol-induced acute liver injury in mice. The main factor in influencing the extraction rate of Phaeoporus obliquus polysaccharide were extraction power and time, which was a kind of pyran glucose by infrared spectroscopy. CCl and alcohol were employed respectively to establish CCl4 and alcohol-induced acute liver injury mouse models.

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Sunflower ( L.) contains active ingredients, such as flavonoids, alkaloids and tannins. Nevertheless, few studies have focused on essential oil from the receptacle of sunflower (SEO).

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Article Synopsis
  • The study investigates isoquercitrin, a compound that inhibits dipeptidyl peptidase IV (DPP-IV), and its effects on the release of the gut hormone glucagon-like peptide-1 (GLP-1) in normal mice and NCI-H716 cells.
  • Isoquercitrin was found to be a competitive inhibitor of DPP-IV, showing significant potential for stimulating GLP-1 release and lowering fasting blood glucose levels in a type 2 diabetic mouse model.
  • Additionally, the results indicated that isoquercitrin improved insulin sensitivity and decreased post-meal blood glucose spikes in a dose-dependent manner.
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Purpose: To identify key genes related to the effect of estrogen on ovarian cancer.

Methods: Microarray data (GSE22600) were downloaded from Gene Expression Omnibus. Eight estrogen and seven placebo treatment samples were obtained using a 2 × 2 factorial designs, which contained 2 cell lines (PEO4 and 2008) and 2 treatments (estrogen and placebo).

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Protein tyrosine phosphatases (PTPs) are enzymes that catalyze protein tyrosine dephosphorylation of which Src homology phosphatase-1 (SHP-1) is one of the best-validated, a widely distributed intracellular tyrosine phosphatase that contains two SH2 domains. Down regulation of SHP-1 tyrosine phosphatases was significantly increased sensitivity to insulin in insulin signaling pathway. Through in vitro enzymatic reaction kinetics experiment, we found that the extract of Perilla stem was a potential inhibitor to δSHP-1, the catalytic domain of SHP-1 protein tyrosine phosphatase, and its IC(50) was 4ug/ml, and was more sensitive towards SHP-1than other PTPs, which indicated that SHP-1 might be a target of the extract of Perilla stem.

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The inhibition of 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR) is considered able to decrease serum cholesterol levels and dramatically reduce the risk for cardiovascular and cerebrovascular diseases. The statins, competitive inhibitors of HMGCR, have been employed to control hypercholesterolemia. But their side effects, especially their safety of long-term administration have attracted great attention.

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Surface modified ZnO quantum dots (QDs) with ultrastable, strong and tunable luminescence have been successfully prepared via silanization during the growth process by (3-(2,3-epoxypropoxy)propyl)trimethoxysilane. The as-prepared ZnO QDs are demonstrated to be promising for anti-counterfeit applications in expensive high-end liquors, etc.

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