Publications by authors named "Wan-Zen Yao"
Background: Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitation, and has many components including mucus hypersecretion, oxidative stress, and airway inflammation. We aimed to assess whether carbocisteine, a mucolytic agent with anti-inflammatory and antioxidation activities, could reduce the yearly exacerbation rate in patients with COPD.
Methods: We did a randomised, double-blind, placebo-controlled study of 709 patients from 22 centres in China.