Publications by authors named "Wan-Ze Li"
The remyelination process within the diabetes mellitus (DM) brain is inhibited, and dynamic interactions between DNA methylation and transcription factors are critical for this process. Repressor element-1 silencing transcription factor (REST) is a major regulator of oligodendrocyte differentiation, and the role of REST on DM remyelination remains to be investigated. Here, we investigated the effects of REST and DNA methylation on DM remyelination and explored the underlying mechanisms.
View Article and Find Full Text PDFArticle Synopsis
- Diabetic cognitive dysfunction (DCD) is linked to oligodendrocytes and granzyme B (GZMB), which may cause axonal damage; this study investigates GZMB's role in DCD.* -
- Using a mouse model of diabetes, researchers assessed learning and memory through a water maze, while examining the effects of a GZMB inhibitor (SerpinA3N) on myelin integrity and cellular stress.* -
- Results indicated that inhibiting GZMB improved cognitive function, reduced stress in oligodendrocytes, enhanced myelin protein expression, and decreased demyelination, suggesting a therapeutic target for DCD.*