Development of a yeast cell based method for efficient screening of high yield tacrolimus production strain.

Unlabelled: Tacrolimus (FK506) is a widely used and clinically important immunosuppressant drug that can be produced by fermentation of . The industrial strains are typically obtained through multiple rounds of mutagenesis and screening, a labor-intensive process. We have established an efficient yeast cell based screening method for the evolutionary process of high-FK506-yielding strain.

Two new cadmium(II) coordination polymers based on imidazole-containing ligands: synthesis, structural characterization and fluorescence properties.

The judicious selection of suitable ligands is vitally important in the construction of novel metal-organic frameworks (MOFs) with fascinating structures and interesting properties. Recently, imidazole-containing multidentate ligands have received much attention. Two new Cd coordination frameworks, namely, poly[tris{μ-1,4-bis[(1H-imidazol-1-yl)methyl]benzene-κN:N}tetrakis(nitrato-κO,O')dicadmium], [Cd(NO)(CHN)], (I), and poly[[bis{μ-1,3,5-tris[(1H-imidazol-1-yl)methyl]benzene-κN:N:N}cadmium] hexafluorosilicate], {[Cd(CHN)](SiF)}, (II), have been synthesized and characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction.

Absent Pulmonary Valve Syndrome in a Fetus: A Case Report and Literature Review.

Introduction: The main characteristics of absent pulmonary valve syndrome (APVS) include the absence or hypoplasia of the pulmonary valve, stenosis of the pulmonary valve annulus, and aneurysmal dilatation of the pulmonary trunk and its branches. In the more common type 1, the tetralogy of Fallot-like type, there is a ventricular septal defect, overriding aorta, pulmonary arterial dilatation, and absence of ductus arteriosus, The second type has an intact ventricular septum, less pulmonary artery dilatation, and a patent ductus arteriosus, with or without tricuspid atresia.

Case Report: This APVS had an intact ventricular septum with an absent ductus arteriosus.