Publications by Wan-Yi Guo

Publications by authors named "Wan-Yi Guo"

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[Mechanism of bulleyaconitine A in inhibiting bone destruction of rheumatoid arthritis via Src/PI3K/Akt signaling pathway].

Feng-Yu Huang Wan-Yi Guo Pei-Ping Chen Xin-Zhuo Zhang Zhuo-Hang Li

Zhongguo Zhong Yao Za Zhi

March 2024

Article Synopsis

The study investigates how bulleyaconitine A affects bone destruction in rheumatoid arthritis through the Src/PI3K/Akt signaling pathway.
Researchers identified key RA targets and bulleyaconitine A's potential targets using various databases, and conducted analyses to understand their interactions and functions.
Experimental results show that bulleyaconitine A inhibited the expression of genes linked to osteoclast differentiation, indicating its potential as a treatment for RA-related bone damage.

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[Inhibitory effect of artesunate on bone destruction in rheumatoid arthritis: an exploration based on AhR/ARNT/NQO1 signaling pathway].

Qian Wang Wan-Yi Guo Li-Ling Liu Xue-Ying Tao Na Lin

Zhongguo Zhong Yao Za Zhi

May 2022

This study aimed to explore the effect of artesunate(ARS) on bone destruction in rheumatoid arthritis(RA) based on the aryl hydrocarbon receptor(AhR)/AhR nucleart ranslocator(ARNT)/NAD(P)H quinone dehydrogenase 1(NQO1) signaling pathway. Macrophage-colony stimulating factor(M-CSF) and receptor activator of nuclear factor-κB(RANKL) were used to induce the differentiation of primary bone marrow-derived mouse macrophages into osteoclasts. After intervention with ARS(0.

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Wan-Yi Guo's research focuses on exploring the mechanisms of traditional compounds, such as bulleyaconitine A and artesunate, in the treatment of bone destruction related to rheumatoid arthritis (RA).
The findings indicate that bulleyaconitine A inhibits bone destruction via the Src/PI3K/Akt signaling pathway, while artesunate acts through the AhR/ARNT/NQO1 signaling pathway, suggesting potential therapeutic targets for RA treatment.
Both studies utilize advanced bioinformatics tools to identify key targets related to RA, demonstrating the importance of understanding molecular mechanisms in developing effective treatments.

Publications by authors named "Wan-Yi Guo"

[Mechanism of bulleyaconitine A in inhibiting bone destruction of rheumatoid arthritis via Src/PI3K/Akt signaling pathway].

Article Synopsis

[Inhibitory effect of artesunate on bone destruction in rheumatoid arthritis: an exploration based on AhR/ARNT/NQO1 signaling pathway].

Synopsis of recent research by authors named "Wan-Yi Guo"