The mode of yearly biological cycle of malignant growth of hepatocellular carcinoma on computed tomography.

Objective: To detect the mode of yearly biological cycle of malignant biological behavior of hepatocellular carcinoma (HCC).

Methods: Twenty-one kinds of CT signs reflecting various degrees of malignant biological behavior were determined. A total of 360 patients were collected by random sampling of 30 patients each month.

[Comparison of the yearly cycle cosine curve imitative parameters of the clinical features of liver cancer at different longitude and latitude].

Objective: To explore whether there exists coincidence of the most appearing time of clinical features of liver cancer at different longitude and latitude, according to the law of field equation and the theory of warpage of space time by Einstein.

Methods: Three regions with different longitude and latitude were selected randomly and sampled. There were 36 items altogether, including 12 clinical items, which were used to imitate the yearly cycle cosine curve.

[Chronobiologic contrast of expression of p53, p16, and cyclin D1 in hepatocarcinoma cells].

Objective: To contrast the feature of different periods of p53, p16, and cyclin D1 expression in cells of hepatocarcinoma.

Methods: Sixty hepatocarcinoma specimens were collected and divided into three periods in one yearly cycle with each period of 20 cases. Hepatocellular carcinoma was documented in all cases by pathomorphological classification.