Aberrant , , and expression in the cytobrushed samples from oral potentially malignant disorders.

Background/purpose: MicroRNA (miRNA) alterations play important roles in the neoplastic process of oral squamous cell carcinoma (OSCC). Upregulation of and and downregulation of are frequent events in OSCC. The aberrances of these miRNAs in oral potentially malignant lesions (OPMD) were studied to determine their status during the establishment of OSCC.

Co-upregulation of and its host gene lncRNA in oral squamous cell carcinoma.

Background/purpose: Several long non-coding RNAs (lncRNAs) harbor miRNA in their genome. MIR31HG harbors miR-31 in its intron and it is speculated that they are co-expressed in tumors. This study addressed whether frequent miR-31 and MIR31HG co-upregulation occurred in oral squamous cell carcinoma (OSCC) and its clinical implications.

LncRNA Drives Oncogenicity by Inhibiting the Limb-Bud and Heart Development Gene () during Oral Carcinoma.

The host gene () encodes a long non-coding RNA (LncRNA) that harbors in its intron 2; promotes malignant neoplastic progression. Overexpression of and of occurs during oral squamous cell carcinoma (OSCC). However, the downstream effectors modulated by during OSCC pathogenesis remain unclear.

The upregulation of oncogenic miRNAs in swabbed samples obtained from oral premalignant and malignant lesions.

Objectives: Oncogenic miRNAs upregulated in OSCC play a range of versatile roles in oral carcinogenesis. Oral potentially malignant disorders (OPMDs) are the antecedent lesions to oral squamous carcinoma (OSCC) and they require a definitive diagnosis and early intervention. This study hypothesizes the presence of aberrant oncogenic miRNA expression in swabbed oral lesions.