Positive association between IL-16 rs1131445 polymorphism and cancer risk: a meta-analysis.

Introduction: The association between IL-16 rs1131445 polymorphism and cancer risk is not consistent or even contradictory, this meta-analysis aims to investigate the role of IL-16 gene rs1131445 polymorphisms in the risk of cancer.

Evidence Acquisition: A comprehensive online search was conducted in PubMed, EMBASE and CNKI databases to identify eligible studies. The case-control studies related IL-16 rs1131445 C/T polymorphism with the cancer susceptibility were selected according to the inclusion and exclusion criteria.

MiR-21/RASA1 axis affects malignancy of colon cancer cells via RAS pathways.

Aim: To determine how the oncogene miR-21 regulates the RAS signaling pathways and affects colon cancer cell behaviors.

Methods: RAS p21 GTPase activating protein 1 (RASA1) protein expression in six colon cancer cell lines was assessed by Western blot. Colon cancer RKO cells were chosen for transfection because they are KRAS wild type colon cancer cells whose RASA1 expression is significantly decreased.