Publications by authors named "Wan-Wan Sun"
A new species, Apecholinus speciosus Sun & Liu, sp. nov. collected from Mangshan, Hunan Province, China, is described.
View Article and Find Full Text PDFWhether amino acids act on cellular insulin signaling remains unclear, given that increased circulating amino acid levels are associated with the onset of type 2 diabetes (T2D). Here, we report that phenylalanine modifies insulin receptor beta (IRβ) and inactivates insulin signaling and glucose uptake. Mice fed phenylalanine-rich chow or phenylalanine-producing aspartame or overexpressing human phenylalanyl-tRNA synthetase (hFARS) develop insulin resistance and T2D symptoms.
View Article and Find Full Text PDFArticle Synopsis
- - Serum samples were tested for IgG antibodies, and a positive result was defined as being reactive at a dilution greater than 1:320; Chi-square tests and generalized linear models were used for statistical analysis of associated risk factors.
- - Out of 1,260 samples, 122 (9.68%) tested positive for infection, with rates varying significantly from 0% to 30.43% across different age groups, particularly higher in individuals aged 50-59 years.
- - The study found significant variations in seroprevalence across different sites in four provinces, and field workers had a notably higher infection rate compared to urban workers.
Elevated whole blood viscosity is associated with insulin resistance and non-alcoholic fatty liver.
Clin Endocrinol (Oxf)
December 2015
Background: Accumulating evidences demonstrate that abnormalities in whole blood viscosity (WBV) have been implicated in insulin resistance which may lead to non-alcoholic fatty liver disease (NAFLD). However, epidemiological studies exploring the association between WBV and NAFLD were not available.
Objective: Our objective was to evaluate the association between WBV levels and risk of prevalent NAFLD.