Publications by authors named "Wan-Tong Zhang"
Article Synopsis
- Fuqi Guben Gao (FQGBG) is a botanical drug used to treat nocturia linked to kidney-yang deficiency by combining several traditional medicinal plants, but its safety and pharmacological effects need further study.
- Recent research on FQGBG demonstrated its effectiveness in reducing urination and improving immune organ damage in rat models of kidney-yang deficiency, while also assessing its safety in a clinical trial with healthy participants.
- The results indicated significant improvements in symptoms with no major adverse events occurring during dose escalation, although some minor side effects were reported; pharmacokinetic analysis showed varying levels of certain compounds within FQGBG.
Article Synopsis
- A randomized clinical trial in China evaluated the effectiveness of electronic cigarettes (ECs), nicotine replacement therapy (NRT), and varenicline in helping smokers quit, involving 1068 participants who smoked at least 10 cigarettes per day and were ready to stop.
- The study found that 6-month abstinence rates were 15.7% for the EC group, 14.2% for the varenicline group, and 8.8% for the NRT group, indicating that ECs were more effective than NRT and comparable to varenicline.
- Participants received minimal behavioral support and the main measure of success was verified sustained abstinence, where those lost to follow-up were counted as non-abstainers
Background: Patients with systemic lupus erythematosus (SLE) are at increased risk of cardiovascular disease (CVD) compared to the general population. However, little is known about the effects of tobacco smoking on CVD in patients with SLE.
Objective: To systematically review and summarize the available literature regarding the effects of tobacco smoking on developing CVD in patients with SLE.
[Evidence mapping of clinical research on traditional Chinese medicine in treatment of diabetic foot].
Zhongguo Zhong Yao Za Zhi
July 2022
The present study comprehensively summarized the clinical randomized controlled trials(RCTs) and systematic reviews/Meta-analyses of traditional Chinese medicine(TCM) in the treatment of diabetic foot by evidence mapping and clarified the distribution of evidence in this field.CNKI, Wanfang, VIP, SinoMed, PubMed, EMbase, and Web of Science were searched for clinical RCTs and systematic reviews on TCM in the treatment of diabetic foot published in the past ten years.The evidence was analyzed and displayed in the form of text combined with figures and tables.
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- The study evaluated the safety and effectiveness of Yuanjiang decoction, a traditional Chinese medicine, for treating symptomatic bradyarrhythmia in a low SES population in Beijing from January 2019 to January 2020.
- A total of 184 patients participated, and after 16 weeks of treatment, the favorable outcome rate was approximately 60%, with the most common side effects being dry mouth, constipation, and sleepiness.
- Key factors influencing treatment outcomes included completing at least 8 weeks of treatment, while conditions like atrioventricular block and recent syncope were linked to poorer outcomes.
Introduction: The use of e-cigarettes has become more common in China, but the research on e-cigarettes in China, while growing, is still limited. This study examined the characteristics and patterns of e-cigarette use, and analyzed the possible mediators between cigarette cessation intention and e-cigarette use in a Chinese smoking population.
Methods: This was a cross-sectional study conducted in mainland China.
Background: Capsule of alkaloids from leaf of Alstonia scholaris (CALAS) is a new investigational botanical drug (No. 2011L01436) for respiratory disease. Clinical population pharmacokinetics (PK), metabolomics and therapeutic data are essential to guide dosing in patients.
View Article and Find Full Text PDFMultiple studies have revealed that idiopathic pulmonary fibrosis (IPF) patients are more at risk for cardiovascular diseases and that many IPF patients receive cardiovascular medications like statins, angiotensin-converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB), and anticoagulants. Existing studies have reported divergent findings on the link between cardiovascular medications and fibrotic disease processes. The aim of this study is to synthesize the evidence on the efficacy of cardiovascular medications in IPF.
View Article and Find Full Text PDFAdministration of aspirin has the potential for significant side effects of gastrointestinal (GI) injury mainly caused by gastric acid stimulation, especially in long-term users or users with original gastrointestinal diseases. The debate on the optimal treatment of aspirin-induced gastrointestinal injury is ongoing. We aimed to compare and rank the different treatments for aspirin-induced gastrointestinal injury based on current evidence.
View Article and Find Full Text PDFCombination of Xuesaitong and Aspirin Based on the Antiplatelet Effect and Gastrointestinal Injury: Study Protocol for a Randomized Controlled Noninferiority Trial.
Evid Based Complement Alternat Med
July 2021
Background: Aspirin is the first-line medication for prevention and treatment of coronary heart disease (CHD). However, long-term use of aspirin resulting in gastrointestinal mucosal injury and bleeding limits the regularity of medication. Xuesaitong is a marketed Chinese medicine contained main active component in Panax notoginseng saponins (PNS), which can significantly inhibit platelet aggregation in patients with CHD.
View Article and Find Full Text PDFBackground: Alstonia scholaris (Apocynaceae) was reported to be a rich source of indole alkaloids, which exhibited remarkably bioactivities. The leaf of A. scholaris has been used in 'dai' ethno-medicine for treatment of respiratory diseases, and the defined indole alkaloids from leaf of A.
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