Publications by authors named "Wan-Tong Ma"
Article Synopsis
- Neocryptolepine derivatives, especially 8-Fluoroneocryptolepine (8FNC), have shown promising cytotoxic effects against gastric cancer, demonstrating greater potency than traditional treatments like cisplatin and fluorouracil.
- 8FNC's effectiveness was enhanced through structural modifications, allowing it to selectively target AGS gastric cancer cells while reducing harm to healthy gastric mucosa cells (GES-1).
- The compound induces apoptosis in AGS cells by disrupting the cell cycle and influencing the PI3K/AKT signaling pathway, indicating its potential as a lead candidate for gastric cancer treatment.
