Publications by authors named "Wan-Ting Shih"
This nationwide retrospective cohort study examines the association between adults with hearing loss (HL) and subsequent injury risk. Utilizing data from the Taiwan National Health Insurance Research Database (2000-2017), the study included 19,480 patients with HL and 77,920 matched controls. Over an average follow-up of 9.
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- - The study aimed to analyze how clinical factors influence the success of stapedotomy in improving hearing for Taiwanese patients experiencing otosclerosis.
- - Results showed significant improvements in hearing after surgery, particularly related to air conduction thresholds and air-bone gaps, with younger age and certain preoperative hearing loss characteristics linked to better outcomes.
- - The research suggested a gender difference in surgical outcomes, finding that males had stronger correlations between preoperative and postoperative hearing improvements compared to females.
Human mitochondrial NAD(P)-dependent malic enzyme (m-NAD(P)-ME) has a dimer of dimers quaternary structure with two independent allosteric sites in each monomer. Here, we reveal the different effects of nucleotide ligands on the quaternary structure regulation and functional role of the human m-NAD(P)-ME exosite. In this study, size distribution analysis was utilized to investigate the monomer-dimer-tetramer equilibrium of m-NAD(P)-ME in the presence of different ligands, and the monomer-dimer (K) and dimer-tetramer (K) dissociation constants were determined with these ligands.
View Article and Find Full Text PDFBackground/purpose: The high frequency information of consonant messages is important for recognition of speech. Recently, the nonlinear frequency compression (NLFC) technique has been shown to improve the speech perception in patients with high frequency hearing loss. In Mandarin, seven consonants are located over 10-16 kHz.
View Article and Find Full Text PDFObjective: The purpose of this study was to design and to verify a new hearing-aid fitting strategy (Aescu HRL-1) based on the acoustic features of Mandarin. The subjective and objective outcomes were compared to those fitted with NAL-NL1 (National Acoustic Laboratory Non-Linear, version1) in Mandarin-speaking hearing-aid users.
Design: Fifteen subjects with sensorineural hearing loss participated in this preliminary study.