Impaired vessel relaxation response and increased infarct size in smooth muscle cannabinoid receptor 1 knockout mice.

Cannabinoids are reported to regulate cardiovascular functions. Cannabinoid receptors 1 (CB1Rs) are widely expressed in both the neuronal system and vascular system, but the contribution of CB1Rs in vascular smooth muscle (CB1R) to cardiovascular functions is not clear yet. In this research, we analyzed the effects of CB1R on blood pressure, vasoconstriction, and vasodilation abilities by using conditionally CB1R knockout mice (CB1R).

Proton-Conductive 3D Ln Metal-Organic Frameworks for Formic Acid Impedance Sensing.

Metal-organic frameworks (MOFs) as new classes of proton-conducting materials have been highlighted in recent years. Nevertheless, the exploration of proton-conducting MOFs as formic acid sensors is extremely lacking. Herein, we prepared two highly stable 3D isostructural lanthanide(III) MOFs, {(M(μ -HPhIDC)(μ -C O ) (H O))⋅2 H O} (M=Tb (ZZU-1); Eu (ZZU-2)) (H PhIDC=2-phenyl-1H-imidazole-4,5-dicarboxylic acid), in which the coordinated and uncoordinated water molecules and uncoordinated imidazole N atoms play decisive roles for the high-performance proton conduction and recognition ability for formic acid.