Publications by authors named "Wan-Ting Cheng"

Doxorubicin (Dox) is an effective anthracycline anticancer drug. However, recent studies have revealed that Dox resistance is a highly critical issue, and a significant reason for treatment failure. Baicalin is a flavonoid component in the roots of Georgi; however, whether baicalin can increase chemosensitivity in breast cancers is still unclear.

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Background: Cisplatin administration may induce muscle atrophy, thereby reducing the fitness level of patients with head and neck cancer (HNC). To date, only animal studies have been conducted to test the effectiveness of exercise interventions in diminishing side effects of cisplatin.

Aim: To determine whether exercise training improves physical fitness and health-related quality of life (HRQoL) in patients receiving chemotherapy for Head & Neck (H&N).

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Article Synopsis
  • * The paper aims to clarify how schistosomiasis is represented in TCM and explore its historical prevalence in ancient China during a significant period of progress for this disease within TCM.
  • * Through literature analysis, the research seeks to identify key TCM symptom descriptions and alternate names for schistosomiasis, contributing to a deeper understanding of its historical context and significance.
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Objective: To investigate the reasons of natural extinction of snails by comparing the difference of the water chemical properties between the snail-breeding marshland and non-snail marshland in Eastern Dongting Lake areas.

Methods: Three adjoining marshlands in Eastern Dongting Lake areas were selected, one was a snail-breeding marshland, the second was a non-snail marshland, and the third was a boundary zone between them. During the periods of water-rising season, wet season and water-falling season, the water samples from the bottom of 0.

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Objective: To explore the association between infections with HIV and , and to determine the influences of the HIV- coinfections on the immune system of Yi people.

Methods: A block design study was conducted in a Yi county in southwestern China, one of the endemic areas of both HIV/AIDS and in China. All participants were screened for HIV antibodies and antibodies (SjAb) and were classified into four groups: HIV(+)/(-), HIV(-)/ (+), HIV(+)/(+), and HIV(-)/(-).

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Article Synopsis
  • Schistosomiasis, a major tropical disease, is associated with Oncomelania hupensis snails, which are sensitive to environmental changes due to the alteration of the Yangtze River by the Three Gorges Dam.
  • This study examined how different factors like flooding duration, temperature, rainfall, and daylight impact the presence of Oncomelania snails in Hunan Province, China, using data from 1995 to 2002.
  • Findings indicated that areas with snails experienced longer flooding periods and certain climatic conditions, suggesting that the flooding duration is crucial for the snails' geographical distribution.
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Objective: To explore the dynamic changes of snail densities in autumn and winter and the relationship between hydrological and meteorological factors and snail growth and decline.

Methods: From Octobers to Decembers of 2007 to 2014, a bottomland close to eastern Dongting Lake was selected as the study field. The snails and elevation of the points were surveyed, and the hydrological and meteorological data were collected.

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Article Synopsis
  • The study aimed to assess the cost-effectiveness of a comprehensive approach to control schistosomiasis by removing cattle and sheep in Juanshan District, Yueyang City.
  • Data was collected over a decade (2006-2016) regarding infection rates in humans, cattle, sheep, and snails, along with the costs of the control measures.
  • Results showed a significant drop in infection rates among residents from 3.44% in 2006 to 0% in 2016, with varying annual prevention costs, ultimately concluding that this strategy is cost-effective and could be applied to similar regions.
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Objective: To investigate the temporal and spatial distribution of infection of population and its risk factors in Eastern Dongting Lake area in 2012 and 2014, so as to provide the reference for formulating effective intervention measures.

Methods: Junshan District was selected as a study field in Eastern Dongting Lake area. The method of spatial autocorrelation analysis was applied to analyze the change of spatial distribution of infection in Junshan District in 2012 and 2014.

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Article Synopsis
  • The removal of Oncomelania hupensis snails is crucial for controlling schistosomiasis, a parasitic disease.
  • Recent studies highlight the use of molluscicidal organisms as a safe and effective approach to eliminate these snails.
  • The paper reviews existing research on microorganisms that specifically target O. hupensis to support effective control strategies against schistosomiasis.
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Protein phosphatase 2A is one of four major classes of serine/threonine phosphatases. Overexpression of brain-specific regulatory subunit PPP2R2 in neuron cells is implicated in pathogenesis. The alternative splicing of PPP2R2B encodes two isoforms.

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Background: The multifunctional protein phosphatase 2A (PP2A) is a heterotrimeric serine/threonine protein phosphatase composed of a scaffolding, catalytic and regulatory subunits. By modifying various downstream signal transducers, the aberrant expression of the brain-targeted regulatory subunit PPP2R2B is associated with the onset of a panel of neuronal disorders. The alternatively splicing of PPP2R2B encodes two regulatory subunit isoforms that determine cellular distribution of the neuron-specific holoenzyme to mitochondria (Bbeta2) and cytoplasm (Bbeta1), respectively.

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