Publications by authors named "Wan-Shu Guo"
Article Synopsis
- The aggregation of amyloid β-peptide (Aβ) is linked to Alzheimer's disease progression, and a new DNA vaccine, p(Aβ3-10)10-mIL-4, has been developed as a potential treatment.
- Immunization of APP/PS1 transgenic mice with this vaccine resulted in high levels of anti-Aβ antibodies, reduced behavioral impairments, and decreased Aβ deposits in the brain, indicating improved cognitive function.
- The immune response was characterized by a Th2 anti-inflammatory profile, suggesting that the vaccine not only lessened Aβ accumulation but also reduced inflammation, making it a promising therapy for Alzheimer's disease.
Article Synopsis
- Active immunization shows potential for Alzheimer's treatment, but issues like T-lymphocyte infiltration need to be addressed.
- A new vaccine, p(Aβ3-10)10-MT, was developed using a synthesized form of Aβ and melatonin, which successfully induced high levels of anti-Aβ antibodies in mice.
- The vaccine not only lowered Aβ deposits and improved cognitive function but also prompted a beneficial immune response, indicating its potential as an effective treatment for Alzheimer's disease.
