Safety and immunogenicity of an inactivated COVID-19 vaccine, BBIBP-CorV, in people younger than 18 years: a randomised, double-blind, controlled, phase 1/2 trial.

Background: Although SARS-CoV-2 infection often causes milder symptoms in children and adolescents, young people might still play a key part in SARS-CoV-2 transmission. An efficacious vaccine for children and adolescents could therefore assist pandemic control. For further evaluation of the inactivated COVID-19 vaccine candidate BBIBP-CorV, we assessed the safety and immunogenicity of BBIBP-CorV in participants aged 3-17 years.

The prevalence of hepatitis B infection in central China: An adult population-based serological survey of a large sample size.

The objective of this study was to determine the prevalence of serum HBsAg among adults in Henan province, China. A provincial serosurvey of people aged 18-74 years was conducted and individuals for analysis were selected using a multistage stratified random cluster sampling method. A 5-ml serum sample from each person was collected and the serum was tested for the presence of HBsAg, HBcAb, HBsAb, HBeAg, and HBeAb by ELISA.

[Surveillance of adverse events following immunization in Henan Province, China between 2010-2011].

Objective: To analyze the epidemiological features of adverse events following immunization (AEFI) in Henan Province, China and to evaluate the safety of vaccines currently used in Henan.

Methods: The AEFI cases reported in Henan from January 1, 2010 to December 31, 2011 were collected through the China Surveillance System of Information on National Immunization Program. The descriptive method was used for epidemiological analysis.

[Sero-prevalence and associated risk factors on hepatitis C in Maqiao township, Henan province of China].

Objective: To describe the prevalence and risk factors of hepatitis C virus (HCV) occurred in Henan province, at the end of 2011.

Methods: Five villages round Maqiao township, including 5187 residents, were selected for the study. Five-milliliter-blood was drawn from every one of the interviewee.

[Complete genome sequencing of enterovirus 71 (EV71) HENAN08 strain isolated in Henan province].

Objective: To sequence the whole-genome of enterovirus 71 (EV71) srtain isolated from patient with hand, foot and mouth in Henan province in 2008.

Methods: Eight overlapping clones covering the whole viral genome were obtained by RT-PCR and the sequences were determined by Sanger dideoxg-mediated chain termination method.

Results: Data it showed that the full length of enterovirus 71 (EV71) HENAN08 genome (not including Poly A tail) is 7405 bp.

[Surveillance and control of Japanese encephalitis in Henan province, 1950 - 2008].

Objective: To analyze the characteristics and trend of Japanese encephalitis (JE) in Henan province.

Methods: Adopting descriptive epidemiological method to analyze the data on the epidemic situation of JE from 1950 to 2008, and on mosquitoes and host animals at disease surveillance points. The host serum JE IgG antibody was detected by ELISA.

[Studies on heredity rule of the first genealogy regarding fatal familial insomnia in Henan province].

Objective: To investigate the epidemiological, genealogic characteristic, familial history of the families with fatal familial insomnia, its clinical and pathological features as well as the heredity rule of related genes.

Methods: 135 familial members of 7 eras were studied. Vein blood samples from patients as well as from some familial members were collected.

[Epidemiology of pediatric HIV infection in six provinces of China].

Objective: To investigate the epidemiology of pediatric human immunodeficiency virus (HIV) infection in six provinces of China.

Methods: A cross-sectional study was conducted in six provinces with the highest HIV prevalence. Surveys on demographics and HIV-related questions (transmission modes, time of diagnosis, clinical stage, laboratory test) were distributed to clinicians in these provinces.

[Study on the authenticity of parents' memory on their children's immunization status].

Objective: To evaluate the authenticity of the parents' memory on their children's immunization status.

Methods: Two counties and 1 district in each of the 18 prefectures were selected, and parents of the children 1 - 2 years old, residents in counties or floating in district, were studied on the authenticity of their memory regarding their children's immunization status.

Results: The rates of inoculation with all the four expanded programme on immunization (EPI) vaccines were 89.