Bioactive Capnosanes and Cembranes from the Soft Coral .

Two new capnosane-based diterpenoids, flaccidenol A () and 7--pavidolide D (), two new cembranoids, flaccidodioxide () and flaccidodiol (), and three known compounds to were characterized from the marine soft coral , collected off the coast of the island of Pratas. The structures of the new compounds were determined by extensive spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, and spectroscopic data comparison with related structures. The rare capnosane diterpenoids were isolated herein from the genus for the first time.

Anti-Inflammatory Polyoxygenated Steroids from the Soft Coral Lobophytum michaelae.

Three new polyoxygenated steroids, michosterols A-C (-), and four known compounds (-) were isolated from the ethyl acetate (EtOAc) extract of the soft coral , collected off the coast of Taitung. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and comparison of the nuclear magnetic resonance (NMR) data with related steroids. The cytotoxicity of compounds - against the proliferation of a limited panel of cancer cell lines was assayed.

Klyflaccisteroids K-M, bioactive steroidal derivatives from a soft coral Klyxum flaccidum.

New steroids, klyflaccisteroids K-M (1-3), were isolated from a soft coral Klyxum flaccidum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Klyflaccisteroid K (1) is the unique 9,11-secosteroid with a 5,8-epidioxy-9-ene functional group.

New cytotoxic and anti-inflammatory steroids from the soft coral Klyxum flaccidum.

Four new steroids, namely klyflaccisteroids G-J (1-4) were isolated from the Formosan soft coral Klyxum flaccidum. The structures of compounds 1-4 were established by spectral data analysis (IR, MS, 1D and 2D NMR) and comparison of spectral data with those of the related known compounds. Cytotoxicity assay revealed that 4 exhibited inhibition activity against the growth of HT-29, P388 and K562 cancer cell lines, whereas 2 showed selective cytotoxicity toward P388 cells.