Intrinsic Expression of Immune Checkpoint Molecule TIGIT Could Help Tumor Growth by Suppressing the Function of NK and CD8 T Cells.

TIGIT, an immune checkpoint molecule widely expressed on NK cells, activated T cells and Tregs, has been involved in delivering inhibitory signals through the interaction with PVR. The blockade of TIGIT/PVR interaction is a promising approach in cancer immunotherapy. Here, we unexpectedly discovered the expression of TIGIT in murine tumor cells.