Publications by authors named "Wan-Qing Feng"
Background: With the increase of age, multiple physiological functions of people begin gradually degenerating. Regardless of natural aging or pathological aging, the decline in cognitive function is one of the most obvious features in the process of brain aging. Brain aging is a key factor for several neuropsychiatric disorders and for most neurodegenerative diseases characterized by onset typically occurring late in life and with worsening of symptoms over time.
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- Blood-based proteomic analysis is commonly used to find disease biomarkers, but it doesn't fully capture changes in nerve cells in Alzheimer's disease (AD).
- This study employed a multi-omics approach, combining single-nuclei RNA sequencing and serum proteomic data to identify potential AD biomarkers, resulting in the detection of 10 significant candidates.
- Four key biomarkers (NEBL, EPB41L2, FGD4, and MARCKS) were confirmed to be related to the actin cytoskeleton regulation, which is linked to synaptic loss in AD, offering new targets for treatment and prognosis.