LINC01268 promotes epithelial-mesenchymal transition, invasion and metastasis of gastric cancer the PI3K/Akt signaling pathway and targeting MARCKS.

Background: Long non-coding RNAs (lncRNAs) with differential expression characteristics have been found to be closely related to the tumorigenesis and development of gastric cancer (GC), but their specific mechanisms and roles still need to be further elucidated.

Aim: To investigate the expression of LINC01268 in GC and its mechanism of affecting GC progression.

Methods: Real-time quantitative polymerase chain reaction was used to detect the expression of LINC01268 in GC tissues, cell lines and plasma.

Decreased expression of the long non-coding RNA promotes gastric cancer progression by targeting HOXD8 and activating PI3K/Akt signaling pathway.

Background: Long non-coding RNAs (lncRNAs) have been shown to be associated with many tumors. However, the specific mechanism of lncRNAs in the occurrence and development of gastric cancer (GC) has not been fully elucidated.

Aim: To explore the expression level and molecular mechanism of in GC tissues and cells, and analyze its significance in the prognosis of GC.