Publications by authors named "Wan-Lin Xie"
Exosomes Released from CaSR-Stimulated PMNs Reduce Ischaemia/Reperfusion Injury.
Oxid Med Cell Longev
September 2021
Ischemia-reperfusion (I/R) injury caused by acute myocardial infarction (AMI) can initiate a strong inflammatory response. Polymorphonuclear cells (PMNs) are the most important inflammatory cells. Our previous studies found that the calcium-sensing receptor (CaSR) regulates the proinflammatory effects of PMNs.
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- * This study explored the use of AnLaeA, a transcription regulator, and demonstrated its effectiveness in enhancing the production of bioactive compounds, such as diorcinol, in the fungus sp. Z5.
- * The findings reveal that AnLaeA can significantly impact gene expression related to compound synthesis, making it a promising tool for researchers looking to tap into fungal metabolic capabilities.
Article Synopsis
- Calcium-sensing receptors (CaSRs) are present in peripheral blood neutrophils (PMNs) and play a key role in inflammatory responses, although their specific functions in PMNs were previously unknown.
- The study found that PMN activation led to increased expression of CaSR and related proteins, with a CaSR activator, cincalcet, enhancing certain inflammatory responses such as IL-6 secretion while reducing apoptosis rates in PMNs.
- Conversely, using a CaSR inhibitor showed that blocking CaSR and the NF-κB signaling pathway reversed the effects of cincalcet, suggesting that CaSR plays a significant role in regulating PMN functions during inflammation through the NF-κB pathway.