Publications by authors named "Wan-Li Peng"

Article Synopsis
  • Many studies have linked physical activity (PA) to cardiometabolic multimorbidity (CMM), but the effects of PA intensity have not been thoroughly examined.
  • This study investigated how different intensities of PA influence the progression of CMM using a large cohort from the UK Biobank consisting of nearly 360,000 participants aged 37-73.
  • Results showed that engaging in higher intensity physical activity significantly reduced the risk of developing cardiometabolic diseases and mortality compared to those with no vigorous physical activity.
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Background: Aortic dissection (AD) is a fatal cardiovascular disorder without effective medications due to unclear pathogenic mechanisms. Bestrophin3 (Best3), the predominant isoform of bestrophin family in vessels, has emerged as critical for vascular pathological processes. However, the contribution of Best3 to vascular diseases remains elusive.

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Aims: Our previous study demonstrated that Ca2+ influx through the Orai1 store-operated Ca2+ channel in macrophages contributes to foam cell formation and atherosclerosis via the calcineurin-ASK1 pathway, not the classical calcineurin-nuclear factor of activated T-cell (NFAT) pathway. Moreover, up-regulation of NFATc3 in macrophages inhibits foam cell formation, suggesting that macrophage NFATc3 is a negative regulator of atherogenesis. Hence, this study investigated the precise role of macrophage NFATc3 in atherogenesis.

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