Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein.

Mesenchymal stem cell (MSC)-based regenerative therapy is currently regarded as a novel approach with which to repair damaged tissues. However, the efficiency of MSC transplantation is limited due to the low survival rate of engrafted MSCs. Lipopolysaccharide (LPS) production is increased in numerous diseases and serves an essential function in the regulation of apoptosis in a variety of cell types.

Comparison of the pharmacokinetics of linezolid in burn and non-burn rabbits.

Linezolid is effective on many resistant organisms for the treatment of severe infections in burns. However, its pharmacokinetics was difficult to predict after major burns. The study aimed to describe the pharmacokinetic properties of linezolid administered intravenously at a dose of 10 mg/kg in severely burned rabbits in comparison to that in non-burns.

[Voltage dependent anion channel 2 involved mitochondrial apoptosis and its possible regulatory signal pathway in hearts of rats with severe scalds].

Objective: To explore the role of voltage dependent anion channel 2 (VDAC2) involved mitochondrial apoptosis in heart injury of rats with severe scald injury and elucidate its possible regulatory signal pathway.

Methods: A total of 60 Wistar rats were divided into sham scald group (n = 30) and scald group (n = 30) according to a random digital table. Blood and heart tissue samples were harvested at Day 1, 7, 14 post scalding.

[Expressions of endoplasmic reticulum stress associated proteins in livers of severely burned rats].

Objective: To explore the expression of endoplasmic reticulum stress (ERS) associated proteins in livers of severely burned rats and examine its potential significance.

Methods: Sixty-four Wistar rats were randomly divided into the control and burn groups (30% total body surface area full-thickness thermal injury) (n = 32 each). Livers were harvested at Day 1, 4, 7, 14 post-burn.

[The protective effect of recombinant rat ghrelin on gastric mucosa in rats with hemorrhagic shock].

Objective: To investigate the effect of recombinant rat ghrelin on gastric mucosa in rats with hemorrhagic shock.

Methods: Eighteen healthy male Sprague-Dawley (SD) rats were randomly assigned into three groups: control group, hemorrhagic shock group, and ghrelin treatment group, with 6 rats for each group. The hemorrhagic shock model was reproduced in hemorrhagic shock group and ghrelin treatment group, and recombinant rat ghrelin (20 microg/kg) was intravenously administered to rats in ghrelin treatment group when resuscitation begun.