Publications by authors named "Wan-Le Hu"
Article Synopsis
- Metabolic syndrome (MetS) is increasingly recognized as a significant public health issue, and this study explores its relationship with postoperative complications in colorectal cancer surgery, focusing on visceral fat area (VFA) rather than traditional metrics like BMI or waist circumference.
- The study involved 381 rectal cancer patients, identifying specific VFA cut-off values for men (117.9 cm) and women (76.9 cm), and found that those with MetS experienced significantly higher complication rates (34.6% vs. 15.8%).
- The findings indicate that MetS, along with other factors like nutritional risk and tumor location, are independent risk factors for postoperative complications in rectal cancer surgery, highlighting the importance of assessing MetS
Activation of IRE1α-XBP1 pathway induces cell proliferation and invasion in colorectal carcinoma.
Biochem Biophys Res Commun
January 2016
Cell proliferation and tumor metastasis are considered as the main reasons for death in colorectal carcinoma (CRC). IRE1α-XBP1 pathway is the most conserved UPR pathways, which are activated during ER stress caused by the accumulation of unfolded or misfolded protein in the lumen of ER. Here, we demonstrated the critical role of IRE1α-XBP1 pathway and underlying molecular mechanism in cell proliferation and tumor metastasis in CRC.
View Article and Find Full Text PDF[Antitumor effect of capsaicin on colorectal carcinoma xenograft in nude mice].
Zhonghua Zhong Liu Za Zhi
April 2013
Objective: To evaluate the effect of capsaicin on nude mice xenografted with colorectal carcinoma cells, and to explore its mechanism of action.
Methods: A nude mouse model of colorectal cancer was established by subcutaneous inoculation of human colorectal carcinoma HT-29 cells. Terminal deoxynucleotidyl transferase-mediated nicked labeling assay (TUNEL) was undertaken to detect the cell proliferation and apoptosis in the xenograft tissue in nude mice.