Publications by authors named "Wan-Ju Tsai"
Human noroviruses (HuNVs) are the leading cause of gastroenteritis worldwide. NS1.2 is critical for HuNV pathogenesis, but the function is still unclear.
View Article and Find Full Text PDFBackground: To construct and externally validate a prediction model for neonate unplanned rehospitalization within 31 days of discharge.
Methods: A retrospective study was performed in the Department of Neonatology of the Children's Hospital of Fudan University. A binominal regression method was applied to construct and validate the prediction model.
Article Synopsis
- - Prenatal exposure to chlorpyrifos, a common pesticide, was linked to changes in DNA methylation and trimethylation levels of the PPARγ gene in the placenta, which could negatively impact fetal growth and neurodevelopment.
- - In a study of 425 mother-infant pairs, increased chlorpyrifos levels corresponded with higher PPARγ DNA methylation and poorer cognitive and language outcomes in 2-year-old boys.
- - PPARγ H3K4me3 levels were positively correlated with better gestational age, birth weight, birth length, and gross-motor skills, indicating that proper function of this gene may support healthier birth outcomes.
BGLF2 is a tegument protein of the Epstein-Barr virus (EBV). This study finds that BGLF2 is expressed in the late stage of the EBV lytic cycle. Microscopic investigations reveal that BGLF2 is present in both the nucleus and the cytoplasm and colocalized with BBLF1 and gp350 at juxtanuclear regions in the cytoplasm.
View Article and Find Full Text PDFBackground/aims: Hematological abnormalities during hepatitis C virus (HCV) combination therapy with pegylated interferon α and ribavirin often necessitate dose reduction. Variants of the ITPA gene have been reported to protect against anemia during the early stages of HCV combina-tion treatments but have also been associated with larger decreases in platelet counts. We aimed to identify the as-sociation between specific ITPA gene polymorphisms and hematological abnormalities in patients undergoing HCV combination therapy.
View Article and Find Full Text PDFAutophagy is an intracellular degradation pathway that provides a host defense mechanism against intracellular pathogens. However, many viruses exploit this mechanism to promote their replication. This study shows that lytic induction of Epstein-Barr virus (EBV) increases the membrane-bound form of LC3 (LC3-II) and LC3-containing punctate structures in EBV-positive cells.
View Article and Find Full Text PDFArticle Synopsis
- hspA encodes a small heat shock protein (sHSP) in Xanthomonas campestris pv. campestris, which is important for plant disease, and its expression is specifically induced by heat shock.
- An hspA mutant shows reduced heat tolerance but maintains its ability to cause disease, indicating its role in stress response rather than pathogenicity.
- HspA forms oligomeric complexes that enhance protein protection against heat, demonstrating potential for use in protein storage applications.