Wearable, self-administered transcranial photobiomodulation for major depressive disorder and sleep: A randomized, double blind, sham-controlled trial.

Background: Device-based treatments exist in psychiatry for decades, but are usually operated by clinicians and require multiple office visits. Near-infrared transcranial photobiomodulation (tPBM) is a safe neurostimulation modality with potential antidepressant and hypnotic effects. We investigated the feasibility and efficacy of adjunctive tPBM treatment, self-administered by a wearable headband.

γδ T cells: The potential role in liver disease and implications for cancer immunotherapy.

The γδ T cell subset was discovered over 30 years ago, yet continues to be an exciting and challenging component of the adaptive immune response. While γδ T cells represent a very small fraction of all T cells in humans, γδ T cells have a vital effect on human immunity, serving as a bridge between the innate and adaptive immune systems. The characteristics of γδ T cells include recognition of non-MHC restrictive antigens, as well as the ability to secrete an abundance of cytokines, suggesting that γδ T cells have high antitumor activity.

Radially realigning nematic liquid crystal for efficient tuning of microring resonators.

The efficient tuning of microring resonator with the radially realigning nematic liquid crystal (NLC) cladding is presented. By applying the voltage on the in-plane annular electrodes, the produced electric field realigns the homeotropically-aligned NLC in the radial direction. Under the voltage sufficient for 90° NLC reorientation, the guided mode senses the consistent cladding index distribution along the microring waveguide with the maximal index change equal to the optical anisotropy of NLC.