Circ ubiquitin-like-containing plant homeodomain and RING finger domains protein 1 increases the stability of G9a and ubiquitin-like-containing plant homeodomain and RING finger domains protein 1 messenger RNA through recruiting eukaryotic translation initiation factor 4A3, transcriptionally inhibiting PDZ and homeobox protein domain protein 1, and promotes the metastasis of hepatocellular carcinoma.

Background And Aim: Circular ubiquitin-like, containing PHD and ring finger domains 1 (circUHRF1) is aberrantly upregulated in human hepatocellular carcinoma (HCC) tissues. However, the underlying molecular mechanisms remain obscure. The present study aimed at elucidating the interactive function of circUHRF1-G9a-ubiquitin-like, containing PHD and ring finger domains 1 (UHRF1) mRNA-eukaryotic translation initiation factor 4A3 (EIF4A3)-PDZ and LIM domain 1 (PDLIM1) network in HCC.

Flow-induced surface crystallization of granular particles in cylindrical confinement.

An interesting phenomenon that a layer of crystallized shell formed at the container wall during an orifice flow in a cylinder is observed experimentally and is investigated in DEM simulation. Different from shear or vibration driven granular crystallization, our simulation shows during the flow the shell layer is formed spontaneously from stagnant zone at the base and grows at a constant rate to the top with no external drive. Roughness of the shell surface is defined as a standard deviation of the surface height and its development is found to disobey existed growth models.