Publications by authors named "Wan-Jia Qin"
Cell Mol Biol Lett
March 2024
Article Synopsis
- RNA-binding proteins (RBPs), like CELF1, are crucial in managing RNA processes such as splicing and translation, influencing both normal and disease states in the body.
- CELF1 specifically interacts with GU-rich elements in mRNA and is linked to the development of various malignant diseases, suggesting it could be a promising target for treatment.
- The text discusses CELF1's structure, function, regulatory mechanisms, and the challenges in studying its role, emphasizing the importance of developing targeted therapies that involve CELF1.
Front Pharmacol
September 2022
Article Synopsis
- Breast cancer (BC) is the most commonly diagnosed cancer globally since 2020, and histone methylation plays a significant role in its development.
- Lysine-specific demethylase 1 (LSD1) is a key enzyme that removes methyl groups from histones and is implicated in cancer progression, particularly in breast cancer through various mechanisms.
- The review discusses LSD1's structure, its mechanisms of action in breast cancer, the potential of LSD1 inhibitors as a treatment, and the future challenges and opportunities in targeting LSD1 for BC therapy.
